TheraRadar

Pharma Intelligence, Simplified

Data updated: Mar 10, 2026

RETIN-A

TRETINOIN
Dermatology Approved 1971-10-20
Jump to: Indications Approvals Trials Competitors Similar Safety Patents
6
Indications
--
Phase 3 Trials
1
Priority Reviews
54
Years on Market

Details

Status
Prescription
First Approved
1971-10-20
Routes
TOPICAL
Dosage Forms
CREAM, SWAB, SOLUTION, GEL

Companies

VALEANT PHARMS NORTH VALEANT BERMUDA VALEANT INTL BAUSCH
Active Ingredient: TRETINOIN

RETIN-A Approval History

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What RETIN-A Treats

1 indications

RETIN-A is approved for 1 conditions since its original approval in 1971. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Acne Vulgaris
Source: FDA Label

RETIN-A Competitors

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3 other drugs also target RARalpha. Compare mechanisms, indications, and trial activity.

ALTRENO
DOW PHARM
TWYNEO
MAYNE PHARMA
ATRALIN
DOW PHARM
Drug = Competitor name Company = Manufacturer N indic. = FDA-approved indications → Date = Patent/exclusivity expiry

Competitors share the same molecular target (RARalpha). Earlier expiry dates signal biosimilar/generic opportunities.

Drugs Similar to RETIN-A

FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.

ACANYA
BENZOYL PEROXIDE
1 shared
BAUSCH
Shared indications:
Acne Vulgaris
ACZONE
DAPSONE
1 shared
ALMIRALL
Shared indications:
Acne Vulgaris
ADAPALENE AND BENZOYL PEROXIDE
ADAPALENE
1 shared
PADAGIS ISRAEL
Shared indications:
Acne Vulgaris
AKLIEF
TRIFAROTENE
1 shared
GALDERMA LABS LP
Shared indications:
Acne Vulgaris
ALTRENO
TRETINOIN
1 shared
DOW PHARM
Shared indications:
Acne Vulgaris
AMZEEQ
MINOCYCLINE HYDROCHLORIDE
1 shared
JOURNEY
Shared indications:
Acne Vulgaris
ARAZLO
TAZAROTENE
1 shared
BAUSCH
Shared indications:
Acne Vulgaris
ATRALIN
TRETINOIN
1 shared
DOW PHARM
Shared indications:
Acne Vulgaris
AVAGE
TAZAROTENE
1 shared
ALMIRALL
Shared indications:
Acne Vulgaris
AZELEX
AZELAIC ACID
1 shared
ALMIRALL
Shared indications:
Acne Vulgaris
BENZAMYCIN
BENZOYL PEROXIDE
1 shared
VALEANT INTL
Shared indications:
Acne Vulgaris
CABTREO
ADAPALENE
1 shared
BAUSCH
Shared indications:
Acne Vulgaris
CLEOCIN T
CLINDAMYCIN PHOSPHATE
1 shared
Pfizer
Shared indications:
Acne Vulgaris
CLINDA-DERM
CLINDAMYCIN PHOSPHATE
1 shared
PADAGIS US
Shared indications:
Acne Vulgaris
CLINDAGEL
CLINDAMYCIN PHOSPHATE
1 shared
BAUSCH
Shared indications:
Acne Vulgaris
CLINDAMYCIN PHOSPHATE
CLINDAMYCIN PHOSPHATE
1 shared
TARO
Shared indications:
Acne Vulgaris
CLINDAMYCIN PHOSPHATE AND BENZOYL PEROXIDE
BENZOYL PEROXIDE
1 shared
Teva
Shared indications:
Acne Vulgaris
CLINDAMYCIN PHOSPHATE AND TRETINOIN
CLINDAMYCIN PHOSPHATE
1 shared
SOLARIS PHARMA CORP
Shared indications:
Acne Vulgaris
CLINDAMYCIN PHOSPHATE IN 0.9% SODIUM CHLORIDE
CLINDAMYCIN PHOSPHATE
1 shared
Baxter
Shared indications:
Acne Vulgaris
CLINDAMYCIN PHOSPHATE IN 5% DEXTROSE IN PLASTIC CONTAINER
CLINDAMYCIN PHOSPHATE
1 shared
RISING
Shared indications:
Acne Vulgaris
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Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

ClinicalTrials.gov ↗ Pro

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

RETIN-A FDA Label Details

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Indications & Usage

FDA Label (PDF)

RETIN-A is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.

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Data Sources

FDA Approval: NDA017340 → Label: DailyMed → Patents: FDA Orange Book → Trials: ClinicalTrials.gov →

Data sourced from official FDA and NIH databases. Click links to verify on original sources.