NIACOR

Pharmacokinetics Following an oral dose, the pharmacokinetic profile of nicotinic acid is characterized by rapid absorption from the gastrointestinal tract and a short plasma elimination half-life. At a 1 gram dose, peak plasma concentrations of 15 to 30 µg/mL are reached within 30 to 60 minutes. Approximately 88% of an oral pharmacologic dose is eliminated by the kidneys as unchanged drug and nicotinuric acid, its primary metabolite. The plasma elimination half-life of nicotinic acid ranges fro...

ADVERSE REACTIONS Cardiovascular: Atrial fibrillation and other cardiac arrhythmias, orthostasis, hypotension. Gastrointestinal: Dyspepsia, vomiting, diarrhea, peptic ulceration, jaundice, abnormal liver function tests. Skin: Mild to severe cutaneous flushing, pruritus, hyperpigmentation, acanthosis nigricans, dry skin. Metabolic: Decreased glucose tolerance, hyperuricemia, gout. Eye: Toxic amblyopia, cystoid macular edema. Nervous System / Psychiatric: Headache.

CONTRAINDICATIONS Nicotinic acid is contraindicated in patients with a known hypersensitivity to any component of this medication; significant or unexplained hepatic dysfunction; active peptic ulcer disease; or arterial bleeding.

Drug Interactions HMG‑CoA Reductase Inhibitors See WARNINGS, Skeletal Muscle . Antihypertensive Therapy Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. Aspirin Concomitant aspirin may decrease the metabolic clearance of nicotinic acid. The clinical relevance of this finding is unclear. Other Concomitant alcohol or hot ...