TheraRadar

Pharma Intelligence, Simplified

Data updated: Mar 10, 2026

GYNAZOLE-1

BUTOCONAZOLE NITRATE
Infectious Disease Approved 2012-05-18
1
Indication
--
Phase 3 Trials
13
Years on Market

Details

Status
Prescription
First Approved
2012-05-18
Routes
VAGINAL
Dosage Forms
CREAM

Companies

Active Ingredient: BUTOCONAZOLE NITRATE

GYNAZOLE-1 Approval History

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What GYNAZOLE-1 Treats

1 indications

GYNAZOLE-1 is approved for 1 conditions since its original approval in 2012. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Vulvovaginal Candidiasis
Source: FDA Label

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

GYNAZOLE-1 FDA Label Details

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Indications & Usage

GYNAZOLE • 1 ® Butoconazole Nitrate Vaginal Cream USP, 2% is indicated for the local treatment of vulvovaginal candidiasis (infections caused by Candida ). The diagnosis should be confirmed by KOH smears and/or cultures (see CLINICAL STUDIES ). Note: GYNAZOLE • 1 ® Butoconazole Nitrate Vaginal Cream USP, 2% is safe and effective in non-pregnant women; however, the safety and effectiveness of this product in pregnant women has not been established (see PRECAUTIONS - Pregnancy ).

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.