GVOKE HYPOPEN

AbsorptionGlucagon injected through the intramuscular route achieved mean peak plasma levels of 6.9 ng/mL at approximately 13 minutes after dosing; and 7.9 ng/mL at approximately 20 minutes after subcutaneous dosing. Administration of the intravenous glucagon showed dose proportionality of the pharmacokinetics between 0.25 and 2 mg. Figure 2 Mean (SE) serum glucagon concentrations after subcutaneous injection of glucagon (1 mg) in 25 normal volunteers Figure 2 Mean (SE) serum glucagon concentra...

The following important adverse reactions are described below and elsewhere in the labeling:

• Hypersensitivity and Allergic Reactions [see Warnings and Precautions (5.3) ]
• Necrolytic Migratory Erythema [see Warnings and Precautions (5.5) ]
• Hyperglycemia in Patients with Diabetes Mellitus when Used as a Diagnostic Aid [see Warnings and Precautions (5.6) ]
• Blood Pressure and Heart Rate Increase in Patients with Cardiac Disease when used as a Diagnostic Aid [see Warnings and Precautions (5.7...

Glucagon for Injection is contraindicated in patients with:

• Pheochromocytoma because of the risk of substantial increase in blood pressure [see Warning and Precautions (5.1) ]
• Insulinoma because of the risk of hypoglycemia [see Warning and Precautions (5.2) ]
• Known hypersensitivity to glucagon or any of the excipients in Glucagon for Injection. Allergic reactions have been reported with gluc...

• Substantial Increase in Blood Pressure in Patients with Pheochromocytoma : Contraindicated in patients with pheochromocytoma because Glucagon for Injection may stimulate the release of catecholamines from the tumor. ( 4 , 5.1 )
• Hypoglycemia in Patients with Insulinoma : In patients with insulinoma, glucagon administration may produce an initial increase in blood glucose; however, Glucagon for Injection may stimulate exaggerated insulin release from an insulinoma and cause hypoglycemia. If a ...

7 DRUG INTERACTIONS

Table 1Clinically Significant Drug Interactions with Glucagon for Injection Beta-Blockers Clinical Impact: Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given Glucagon for Injection. Intervention: The increase in blood pressure and heart rate may require therapy in patients with coronary artery disease. Indomethacin Clinical Impa...