NCT06933329 RECRUITING Zelenectide Pevedotin in NECTIN4 Amplified Advanced or Metastatic Non-small Cell Lung Cancer
BicycleTx Limited
NCT07246863 RECRUITING Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC
CatalYm GmbH
NCT06694454 NOT YET RECRUITING Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)
National Cancer Institute (NCI)
NCT06813664 NOT YET RECRUITING ctDNA-Guided CURB for OPD mNSCLC on TKI (CURB-TKI)
University Health Network, Toronto
NCT04716946 ACTIVE NOT RECRUITING Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy
Memorial Sloan Kettering Cancer Center
NCT06634056 NOT YET RECRUITING Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation
University Health Network, Toronto
NCT07444437 NOT YET RECRUITING LM103 in Phase IIa Clinical Trial for Adjuvant Treatment in Patients With Non-small Cell Lung Cancer
Suzhou BlueHorse Therapeutics Co., Ltd.
NCT05546268 ACTIVE NOT RECRUITING Study of Oral MRT-2359 in Selected Cancer Patients
Monte Rosa Therapeutics, Inc
NCT07288177 RECRUITING Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer
Genmab
NCT05180474 ACTIVE NOT RECRUITING GEN1047 for Solid Tumors - First in Human (FIH) Trial
Genmab
NCT06657222 RECRUITING First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
Tubulis GmbH
NCT06693336 RECRUITING An Adjuvant Study to Evaluate SMS001 (Paclitaxel) in Non-Small Cell Lung Cancer
ToLymph Inc.
NCT04683250 RECRUITING Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities
Taiho Pharmaceutical Co., Ltd.
NCT07323732 RECRUITING A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease
Memorial Sloan Kettering Cancer Center
NCT05579366 RECRUITING Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
Genmab
NCT06303505 RECRUITING FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
Tubulis GmbH
NCT06956690 RECRUITING A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors
Hummingbird Bioscience
NCT06275360 RECRUITING Repositioning Immunotherapy in VetArans With Lung Cancer
VA Office of Research and Development
NCT07227298 RECRUITING A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Pfizer
NCT04736823 ACTIVE NOT RECRUITING A Trial of AK112 (PD1/VEGF Bispecific) in Combination With Chemotherapy in Patients With NSCLC
Akeso
NCT06047379 RECRUITING Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Neonc Technologies, Inc.
NCT04318938 ACTIVE NOT RECRUITING Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT07221474 RECRUITING A Study of V940/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)
Merck Sharp & Dohme LLC
NCT07438600 NOT YET RECRUITING A Single-center, Phase II Clinical Study of Sacituzumab Govitecan Combined With Toripalimab as Neoadjuvant Therapy for Resectable Stage II-IIIB NSCLC
Tianjin Medical University Cancer Institute and Hospital
NCT05888402 ACTIVE NOT RECRUITING Induction Chemotherapy and Toripalimab Followed by Chemoradiotherapy for Large-volume Local Advanced NSCLC
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT04606771 ACTIVE NOT RECRUITING A Study Comparing Savolitinib Plus Osimertinib vs Savolitinib Plus Placebo in Patients With EGFRm+ and MET Amplified Advanced NSCLC
AstraZeneca
NCT07435038 NOT YET RECRUITING Study of BPI-572070 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Betta Pharmaceuticals Co., Ltd.
NCT04165070 RECRUITING KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
Merck Sharp & Dohme LLC
NCT03940703 ACTIVE NOT RECRUITING A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)
EMD Serono Research & Development Institute, Inc.
NCT06745882 RECRUITING Prospective Trial Assessing Real World Outcomes Response to Pembro in Black Patients w/ NSCLC
H. Lee Moffitt Cancer Center and Research Institute
NCT03808337 RECRUITING Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of Disease
Memorial Sloan Kettering Cancer Center
NCT07439094 NOT YET RECRUITING A First-in-Human Study of CKD-703 in Advanced Solid Tumors and Non-Small Cell Lung Cancer
Chong Kun Dang Pharmaceutical
NCT07098988 RECRUITING Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC
CatalYm GmbH
NCT07432984 NOT YET RECRUITING Fecal Microbiota Transplant(FMT) Combination With Tislelizumab in Advanced or Metastatic NSCLC
Se-Hoon Lee
NCT02716116 ACTIVE NOT RECRUITING A Study of TAK-788 in Adults With Non-Small Cell Lung Cancer
Takeda
NCT06315010 RECRUITING REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis
MedSIR
NCT06695845 RECRUITING A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Jazz Pharmaceuticals
NCT05081609 ACTIVE NOT RECRUITING A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
Ascendis Pharma Oncology Division A/S
NCT06996782 RECRUITING A Platform Study in Non-Small Cell Lung Cancer (NSCLC)
AstraZeneca
NCT06946797 RECRUITING A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)
Bristol-Myers Squibb
NCT06248606 RECRUITING Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases
Ryan Gentzler, MD
NCT06106802 RECRUITING Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment
Samsung Medical Center
NCT06855771 RECRUITING A Study of BMS-986504 in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)
Bristol-Myers Squibb
NCT06568939 RECRUITING A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
AbbVie
NCT07428044 RECRUITING A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT06219317 RECRUITING Immunotherapy Consolidation After Radical Treatment of Synchronous Oligo-metastatic NSCLC
European Organisation for Research and Treatment of Cancer - EORTC
NCT06043817 RECRUITING First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations
Pierre Fabre Medicament
NCT06448754 RECRUITING Volrustomig Priming Regimens Exploratory Phase II Platform Study
AstraZeneca
NCT05789082 RECRUITING A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Hoffmann-La Roche
NCT06051695 RECRUITING A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
A2 Biotherapeutics Inc.
NCT05635708 ACTIVE NOT RECRUITING A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer
BeiGene
NCT06780085 RECRUITING A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)
Merck Sharp & Dohme LLC
NCT07420439 NOT YET RECRUITING Treatment in Patients With Advanced Non-Small Cell Lung Carcinoma and Interstitial Lung Disease
Intergroupe Francophone de Cancerologie Thoracique
NCT07104630 RECRUITING Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
Case Comprehensive Cancer Center
NCT07223047 RECRUITING A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
Bristol-Myers Squibb
NCT04644068 ACTIVE NOT RECRUITING Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
AstraZeneca
NCT04868877 ACTIVE NOT RECRUITING Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
Merus B.V.
NCT07020221 RECRUITING A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Verastem, Inc.
NCT05715229 RECRUITING Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy
Hackensack Meridian Health
NCT02422381 ACTIVE NOT RECRUITING MK-3475 and Gemcitabine in Non-Small Cell Lung Cancer (NSCLC)
Providence Health & Services
NCT06741085 RECRUITING A Study of Stereotactic Radiosurgery (SRS) and Standard Treatment in People With Lung Cancer That Has Spread to the Brain
Memorial Sloan Kettering Cancer Center
NCT06731907 RECRUITING A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
Merck Sharp & Dohme LLC
NCT05267626 RECRUITING Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
Aulos Bioscience, Inc.
NCT07410494 RECRUITING Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors
Essen Biotech
NCT07030257 RECRUITING Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
Tasca Therapeutics
NCT07418931 NOT YET RECRUITING A Multicenter Open-label Phase II Study of Cemiplimab Plus Chemotherapy, Selected on the Basis of Baseline Cytidine Deaminase Activity, in Advanced Squamous Non-small Cell Lung Cancer
Gruppo Oncologico Italiano di Ricerca Clinica
NCT07418866 NOT YET RECRUITING FANLUNG-2:The Value of High-Low Mixed-Dose Radiotherapy Combined With Chemo-Immunotherapy Induction in Locally Advanced Non-Small Cell Lung Cancer
Fudan University
NCT07413952 NOT YET RECRUITING Limertinib Plus Radiotherapy for EGFR-Mutant NSCLC With Brain Metastases
The First Affiliated Hospital of Guangzhou Medical University
NCT05358249 ACTIVE NOT RECRUITING Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals
NCT05882734 ACTIVE NOT RECRUITING Tuvusertib (M1774) in Combination With Cemiplimab in Participants With Non-Squamous NSCLC (DDRiver NSCLC 322)
EMD Serono Research & Development Institute, Inc.
NCT03412877 RECRUITING Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
National Cancer Institute (NCI)
NCT07412262 NOT YET RECRUITING A Prospective, Single-Arm, Multicenter, Phase II Clinical Study of Chidamide Combined With Ivonescimab in the Treatment of Advanced Non-Small Cell Lung Cancer With Acquired Resistance to Immunotherapy and High YAP Protein Expression
Guangdong Association of Clinical Trials
NCT05663866 ACTIVE NOT RECRUITING Premedication to Reduce Amivantamab Associated Infusion Related Reactions
Janssen Research & Development, LLC
NCT07415005 NOT YET RECRUITING Lorlatinib Plus Local Consolidation Therapy In ALK Positive Advanced Non-Small Cell Lung Cancer
M.D. Anderson Cancer Center
NCT05445843 ACTIVE NOT RECRUITING Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.
Novartis Pharmaceuticals
NCT07410611 NOT YET RECRUITING ctDNA Monitoring Guides the Treatment of NSCLC With Befotertinib Combined With Radiotherapy
Hebei Medical University Fourth Hospital
NCT07408635 RECRUITING IBI363 (PD-1/IL-2α-bias) in Combination With Chemotherapy as Neoadjuvant Therapy in Initially Unresectable Stage III Non-Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT06532032 ACTIVE NOT RECRUITING A Study of Combination Therapy With Amivantamab and Docetaxel in Participants With Metastatic Non-small Cell Lung Cancer
Janssen Research & Development, LLC
NCT06120140 RECRUITING Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
Janssen Research & Development, LLC
NCT05488314 ACTIVE NOT RECRUITING A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer
Janssen Research & Development, LLC
NCT06162572 ACTIVE NOT RECRUITING Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)
Servier Bio-Innovation LLC
NCT05498428 RECRUITING A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Janssen Research & Development, LLC
NCT05123482 RECRUITING A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
AstraZeneca
NCT03767348 ACTIVE NOT RECRUITING Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
Replimune Inc.
NCT06667908 RECRUITING A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Johnson & Johnson Enterprise Innovation Inc.
NCT07410975 RECRUITING Efficacy of Anti-CTLA-4 Antibody Combined With Sintilimab and Chemotherapy as Neoadjuvant Therapy for Resectable Stage II-III Non-Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT05714891 ACTIVE NOT RECRUITING Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer
Canadian Cancer Trials Group
NCT06449313 RECRUITING Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node Involvement
Georgetown University
NCT05985655 RECRUITING Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.
NCT06552234 RECRUITING Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
NCT07154290 NOT YET RECRUITING A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Regeneron Pharmaceuticals
NCT06465329 RECRUITING A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
Regeneron Pharmaceuticals
NCT06656598 RECRUITING Adjuvant Chemotherapy +/- Cemiplimab and Sequential Hypofractionated Radiotherapy in Unfit or Elderly Patients With Stage III Lung Cancer
Intergroupe Francophone de Cancerologie Thoracique
NCT05186974 ACTIVE NOT RECRUITING Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
Gilead Sciences
NCT05775289 ACTIVE NOT RECRUITING A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer
Hoffmann-La Roche
NCT07402070 NOT YET RECRUITING IBI363 as Neoadjuvant Therapy in Resectable Stage II-III Non-Small Cell Lung Cancer
Innovent Biologics (Suzhou) Co. Ltd.
NCT06244771 RECRUITING A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Frontier Medicines Corporation
NCT07082179 RECRUITING A Prospective Phase II Clinical Study of Immunotherapy Combined With Chemotherapy for Stage III Unresectable Non-small Cell Lung Cancer
Jiangsu Cancer Institute & Hospital
NCT05099172 ACTIVE NOT RECRUITING First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
Bayer
NCT07360743 NOT YET RECRUITING Immunotherapy Without Chemotherapy for Advanced Lung Cancer Patients With High PD-L1 Levels
UNICANCER
NCT04585750 RECRUITING The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
PMV Pharmaceuticals, Inc
NCT06878274 RECRUITING Post-operative Radiotherapy After Neodjuvant Chemo-immunotherapy and Surgery in Stage III NSCLC
Centre hospitalier de l'Université de Montréal (CHUM)
NCT07375316 RECRUITING A ctDNA-guided Phase II Trial of Osimertinib in Combination With Sacituzumab Tirumotecan in EGFR-mutated Advanced NSCLC Patients With Positvie ctDNA After lead-in Osimertinib Monotherapy
Guangdong Association of Clinical Trials
NCT04930432 RECRUITING Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors
Betta Pharmaceuticals Co., Ltd.
NCT07398937 RECRUITING Comparison of Serplulimab Versus Nivolumab in Neoadjuvant Therapy for Resectable Stage II-IIIA Squamous NSCLC
Fudan University
NCT03775486 ACTIVE NOT RECRUITING Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)
AstraZeneca
NCT06162221 RECRUITING Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
Revolution Medicines, Inc.
NCT06128551 RECRUITING Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Revolution Medicines, Inc.
NCT04585477 RECRUITING Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E)
Stanford University
NCT04302025 RECRUITING A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
Genentech, Inc.
NCT07397338 RECRUITING Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors
Revolution Medicines, Inc.
NCT06268210 RECRUITING Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer
Yonsei University
NCT03965468 ACTIVE NOT RECRUITING Immunotherapy, Chemotherapy, Radiotherapy and Surgery for Synchronous Oligo-metastatic NSCLC
ETOP IBCSG Partners Foundation
NCT05967689 RECRUITING A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.
Taiho Oncology, Inc.
NCT06250777 ENROLLING BY INVITATION Efficacy and Safety of T-DXd in HER2-mutant Advanced Lung Cancer Patients With Asymptomatic Brain Metastases
Yonsei University
NCT06706076 RECRUITING A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations
BlossomHill Therapeutics
NCT07250477 RECRUITING Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer
University of California, Davis
NCT07392658 RECRUITING Phase II Trial of Amivantamab Plus Monochemotherapy in Platinum Unfit NSCLC Patients With EGFR exon20 Insertion Mutations.
Fondazione Ricerca Traslazionale
NCT04884282 ACTIVE NOT RECRUITING Efficacy of Tedopi Plus Docetaxel or Tedopi Plus Nivolumab as Second-line Therapy in Metastatic Non-small-cell Lung Cancer Progressing After First-line Chemo-immunotherapy (Combi-TED)
Fondazione Ricerca Traslazionale
NCT06924606 RECRUITING Evaluating the Preliminary Efficacy and Safety of JS207 in NSCLC After Progression Following Platinum-based Chemotherapy and Immunotherapy
Shanghai Junshi Bioscience Co., Ltd.
NCT06738160 RECRUITING The Efficacy and Safety of Narlumosbart in Combination With Stereotactic Body Radiation Therapy to Improve the Efficacy of First-line Chemotherapy Combined With Immunotherapy in Patients With Bone Metastases From Advanced Non-small Cell Lung Cancer
Fudan University
NCT04395677 ACTIVE NOT RECRUITING A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene
Nuvation Bio Inc.
NCT07115043 RECRUITING A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
AstraZeneca
NCT06710132 RECRUITING Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)
EMD Serono Research & Development Institute, Inc.
NCT06593522 RECRUITING A Phase 2 Study of AMG 193 in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
Amgen
NCT03141359 ACTIVE NOT RECRUITING Use of High Dose Radiation Followed by Chemotherapy and Radiation to Treat Locally Advanced NSCLC
Wake Forest University Health Sciences
NCT06007937 RECRUITING A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT07098338 RECRUITING A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)
AstraZeneca
NCT04223596 ACTIVE NOT RECRUITING Clinical Utility of Liquid Biopsy in Brigatinib ALK+ Patients
Fundación GECP
NCT02525757 ACTIVE NOT RECRUITING MPDL3280A With Chemoradiation for Lung Cancer
M.D. Anderson Cancer Center
NCT03808662 ACTIVE NOT RECRUITING Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung
Memorial Sloan Kettering Cancer Center
NCT05616624 ACTIVE NOT RECRUITING ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers
Washington University School of Medicine
NCT05443126 RECRUITING A Study of EP0031 in Patients With Advanced RET-altered Malignancies
Ellipses Pharma
NCT03953144 RECRUITING Synapse 3D With Intravascular Indocyanine Green
St. Joseph's Healthcare Hamilton
NCT06638125 NOT YET RECRUITING 3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial
St. Joseph's Healthcare Hamilton
NCT06810544 RECRUITING Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Tango Therapeutics, Inc.
NCT07379398 NOT YET RECRUITING Iparomlimab and Tuvonralimab Injection Combined With SBRT in Patients With Early-Stage Non-Small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT04083599 ACTIVE NOT RECRUITING GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
Genmab
NCT07005336 ACTIVE NOT RECRUITING A Study to Compare Uliledlimab Combined With Sintilimab and Chemotherapy Versus Sintilimab Combined With Chemotherapy in Patients With Previously Untreated Locally Advanced Unresectable or Metastatic Non-small Cell Lung Cancer
TJ Biopharma Co., Ltd.
NCT03974022 ACTIVE NOT RECRUITING Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)
Dizal Pharmaceuticals
NCT05925530 ACTIVE NOT RECRUITING Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)
AstraZeneca
NCT03474497 ACTIVE NOT RECRUITING UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade
Megan Daly, MD
NCT07148128 RECRUITING Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.
Auricula Biosciences Inc.
NCT04467723 RECRUITING Combination of Atezolizumab and Pirfenidone in Second-line and Beyond NSCLC
University of Kansas Medical Center
NCT05500092 ACTIVE NOT RECRUITING An Open Label, Randomized Study of Neoadjuvant Nivolumab and Chemotherapy, With or Without Sub-ablative Stereotactic Body Radiation Therapy, for Resectable Stage IIA to IIIB Non-small Cell Lung Cancer
Montefiore Medical Center
NCT07374419 NOT YET RECRUITING Atamparib in Patients With Advanced Solid Tumors
Nerviano Medical Sciences (Shanghai) Ltd.
NCT06370416 ENROLLING BY INVITATION the Prevention of Bone Marrow Suppression Caused by Chemotherapy in Advanced NSCLC With Trilaciclib
Henan Cancer Hospital
NCT06172478 RECRUITING A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Daiichi Sankyo
NCT07371663 RECRUITING An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors
Beijing Tide Pharmaceutical Co., Ltd
NCT07151040 RECRUITING Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors
One-carbon Therapeutics AB
NCT05751798 RECRUITING Dose-finding and Dose Expansion Study of OSE-279 in Subjects With Advanced Solid Tumors or Lymphomas
OSE Immunotherapeutics
NCT05546866 ACTIVE NOT RECRUITING Study to Assess the Efficacy and Safety of Adjuvant Osimertinib in NSCLC With Uncommon EGFRm
AstraZeneca
NCT05786430 ACTIVE NOT RECRUITING Lazertinib+Pemetrexed/Carboplatin in Patients With EGFR Sensitizing Mutation Positive Recurrent or Metastatic Non-Small Cell Lung Cancer Failed to Prior Lazertinib
Yonsei University
NCT05206812 ACTIVE NOT RECRUITING Window of Opportunity Trial of Durvalumab (MEDI4736) to Identify Immune Dynamics in Operable Non-small Cell Lung Cancer (NSCLC) (MIRACLE)
Yonsei University
NCT07130786 RECRUITING Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases
Ayal A. Aizer, MD
NCT05467748 RECRUITING EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer
VA Office of Research and Development
NCT05816252 ACTIVE NOT RECRUITING A Study of SKB264 (MK-2870; Sac-TMT) for the Treatment of Participants With Advanced or Metastatic Non-small Cell Lung Cancer (SKB264-II-04) (MK-2870-003)
Klus Pharma Inc.
NCT07132190 RECRUITING Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
Ayal A. Aizer, MD
NCT06083857 ACTIVE NOT RECRUITING PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer
M.D. Anderson Cancer Center
NCT07365410 NOT YET RECRUITING Furmonertinib 160mg vs 80mg + Chemotherapy in EGFR-Mutated NSCLC With Brain Metastases: Efficacy and Safety Study
Tianjin Medical University Cancer Institute and Hospital
NCT05553834 ACTIVE NOT RECRUITING PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung
Duke University
NCT07362940 RECRUITING A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib
Henan Genuine Biotech Co., Ltd.
NCT04619004 ACTIVE NOT RECRUITING HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
Daiichi Sankyo
NCT03377023 ACTIVE NOT RECRUITING Phase I/II Study of Nivolumab and Ipilimumab Combined With Nintedanib in Non Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
NCT07269782 RECRUITING A Phase II Study to Evaluate the Efficacy and Safety of HLX43 + Serplulimab as Neoadjuvant Therapy in Subjects With NSCLC
Shanghai Henlius Biotech
NCT07355231 NOT YET RECRUITING Lung Functional Avoidance Radiotherapy Using Hyperpolarized Xenon MRI
Xemed LLC
NCT03392246 ACTIVE NOT RECRUITING A Phase 2 Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer
Dana-Farber Cancer Institute
NCT07358689 NOT YET RECRUITING Toripalimab Combined With Platinum-based Chemotherapy With or Without H1 Receptor Antagonist in the Perioperative Treatment of Resectable Non-small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT06475300 RECRUITING A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT04166487 ACTIVE NOT RECRUITING Plasma-Adapted First-Line Pembro In NSCLC
Julia K. Rotow, MD
NCT07298148 NOT YET RECRUITING Firmonertinib 160 mg in Patients With EGFR-Mutant Advanced NSCLC Demonstrating SD After 8 Week Induction With Firmonertinib 80 mg
Peking University Cancer Hospital & Institute
NCT05673187 ACTIVE NOT RECRUITING Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status
ETOP IBCSG Partners Foundation
NCT07354061 NOT YET RECRUITING Neoadjuvant Therapy With Ensartinib Combined With Chemotherapy for ALK-positive Non - Small Cell Lung Cancer (NSCLC)
Tang-Du Hospital
NCT07020065 NOT YET RECRUITING Reduced-dose Carboplatin-doublet-chemotherapy + Cemiplimab vs Cemiplimab Monotherapy in Treatment Naive Older and Frail Patients With Metastatic NSCLC With PD-L1 <50%
Swiss Cancer Institute
NCT07292168 RECRUITING A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1
Kidney Cancer Research Bureau
NCT07355205 NOT YET RECRUITING First-Line Ipilimumab Plus Nivolumab and Nogapendekin Alfa Inbakicept (N-803) in Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer
Washington University School of Medicine
NCT05601973 ACTIVE NOT RECRUITING Amivantamab, Lazertinib and Bevacizumab in Patients With EGFR-mutant Advanced Non-small Cell Lung Cancer With Progression on Previous Third-generation EGFR-TKI
ETOP IBCSG Partners Foundation
NCT05740943 ACTIVE NOT RECRUITING Induction Lorlatinib in Stage III Non-small Cell Lung Cancer
Guangdong Provincial People's Hospital
NCT05208944 RECRUITING THIO Sequenced With Cemiplimab in Advanced NSCLC
Maia Biotechnology
NCT07353476 NOT YET RECRUITING Radiotherapy Plus Anti-PD-1 Versus Anti-PD-1 Alone in ypTanyN⁺M0 NSCLC
Shanghai Zhongshan Hospital
NCT04743505 ACTIVE NOT RECRUITING Safety and Efficacy of Combining APL-101 With Frontline Osimertinib in Patients With EGFR-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)
Washington University School of Medicine
NCT07227025 RECRUITING A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer
Janssen Research & Development, LLC
NCT05908734 ACTIVE NOT RECRUITING A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer
Janssen Research & Development, LLC
NCT06667076 RECRUITING A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Janssen Research & Development, LLC
NCT06879717 ACTIVE NOT RECRUITING A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients
iOnctura
NCT07306624 RECRUITING Nelmastobart in Combination With Docetaxel in Non Small Cell Lung Cancer
STCube, Inc.
NCT07343479 NOT YET RECRUITING Sacituzumab Tirumotecan Plus Third-Generation TKI With/Without Radiotherapy for EGFR-Mutant NSCLC Brain Metastases
Zhejiang Cancer Hospital
NCT07189871 RECRUITING 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
Radiopharm Theranostics, Ltd
NCT05845671 ACTIVE NOT RECRUITING Amivantamab With Tyrosine Kinase Inhibitors (TKI) for Advanced NSCLC With ALK, ROS1, or RET Alterations
University of Colorado, Denver
NCT03527108 ACTIVE NOT RECRUITING Nivolumab Plus Ramucirumab in Patients With Recurrent, Advanced, Metastatic NSCLC
Fox Chase Cancer Center
NCT07339176 NOT YET RECRUITING Intratumoral N17350 in Advanced Solid Tumors
Onchilles Pharma Inc
NCT03228667 ACTIVE NOT RECRUITING QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
ImmunityBio, Inc.
NCT05089916 ACTIVE NOT RECRUITING Radiation During Osimertinib Treatment: a Safety and Efficacy Cohort Study
AIO-Studien-gGmbH
NCT07332858 NOT YET RECRUITING First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion
Gang Hou
NCT07339839 NOT YET RECRUITING Glecirasib Combined With Ivonescimab for First-line Treatment of KRAS G12C-mutated NSCLC
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT03485209 ACTIVE NOT RECRUITING Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors
Seagen, a wholly owned subsidiary of Pfizer
NCT05651022 ACTIVE NOT RECRUITING Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors
Indaptus Therapeutics, Inc
NCT04769388 ACTIVE NOT RECRUITING Osimertinib Plus Chemotherapy vs Osimertinib in EGFRm NSCLC With Persistence Week-3 ctDNA EGFRm After 1L Osimertinib
Beijing Cancer Prevention & Treatment Society
NCT06161441 ACTIVE NOT RECRUITING A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
Regeneron Pharmaceuticals
NCT05074810 ACTIVE NOT RECRUITING Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
Verastem, Inc.
NCT04686682 RECRUITING A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors
Jacobio Pharmaceuticals Co., Ltd.
NCT07330037 RECRUITING TALENT Study: Phase II Trial of Adjuvant L-TIL Plus Tislelizumab in Resectable NSCLC Without pCR After Neoadjuvant Chemoimmunotherapy
Tianjin Medical University Cancer Institute and Hospital
NCT07330076 NOT YET RECRUITING Iruplinalkib Tablets as Postoperative Adjuvant Therapy in Stage IA ALK-positive NSCLC With High-risk Factors
Tianjin Medical University Cancer Institute and Hospital
NCT07050056 RECRUITING Tislelizumab Combined With Thoracic Radiotherapy as Neoadjuvant Therapy for Resectable NSCLC
Northern Jiangsu People's Hospital
NCT07329322 NOT YET RECRUITING Phase II Study of Sacituzumab Tirumotecan in Combination With Osimertinib or Sacituzumab Tirumotecan for Neoadjuvant Treatment in Patients With Resectable Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
NCT07330596 RECRUITING QL1706 Combined With Chemotherapy in the Treatment of Immune-mediated NSCLC
Anhui Provincial Cancer Hospital
NCT07330050 RECRUITING WAST Cell-Docetaxel Combination Therapy in PD-1 Inhibitor-Resistant Advanced NSCLC
Tianjin Medical University Cancer Institute and Hospital
NCT02568267 ACTIVE NOT RECRUITING Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Hoffmann-La Roche
NCT07322783 RECRUITING Osimertinib Combined With Savolitinib in the Treatment of NSCLC With Low Copy Number MET Amplification
Qingdao Central Hospital
NCT04332367 RECRUITING Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance
Abramson Cancer Center at Penn Medicine
NCT04919811 ACTIVE NOT RECRUITING Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
Nuvation Bio Inc.
NCT07323056 RECRUITING Neoadjuvant Sacituzumab Tirumotecan and Limertinib for Potentially Resectable Stage Ⅲ EGFR-mutant Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT05195632 ACTIVE NOT RECRUITING Phase II Study Investigating the Combination of Encorafenib and Binimetinib in BRAF V600E Mutated Chinese Patients With Metastatic Non-Small Cell Lung Cancer
Pierre Fabre Medicament
NCT05657873 RECRUITING A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)
Memorial Sloan Kettering Cancer Center
NCT07120698 RECRUITING Adaptive Adjuvant Sintilimab Therapy Guided by MRD (ADAPT Lung)
Guangdong Association of Clinical Trials
NCT06903377 RECRUITING Study of ZG005 Combined With Gecacitinib in Patients With Advanced Non-Small Cell Lung Cancer
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
NCT06627738 RECRUITING Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost
Centre Antoine Lacassagne
NCT06877299 RECRUITING Low-Dose Radiation + SBRT + Tislelizumab Plus Platinum-based Chemotherapy in Stage ⅡA-ⅢB Non-small Cell Lung Cancer
Sichuan University
NCT04367311 ACTIVE NOT RECRUITING Adjuvant Treatment With Cisplatin-based Chemotherapy Plus Concomitant Atezolizumab in Patients With Stage I (Tumors ≥ 4cm), IIA, IIB, and Select Stage III [Any T1-3 N1-2 and T4N0-2] Resected Non-small Cell Lung Cancer (NSCLC) and the Clearance of Circulating Tumor DNA (ctDNA)
Nasser Hanna
NCT06295432 RECRUITING A Phase II Clinical Trial of DZD9008 in Combination With AZD4205 in Standard Treatment Failed NSCLC Patients With EGFR Mutations (WU-KONG21)
Dizal Pharmaceuticals
NCT06003231 ACTIVE NOT RECRUITING A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2
Seagen, a wholly owned subsidiary of Pfizer
NCT05463224 ACTIVE NOT RECRUITING Lazertinib for NSCLC Harboring Activating EGFR Mutations in TKI naïve Patients
Se-Hoon Lee
NCT04933903 RECRUITING BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab
Brown University
NCT07309952 NOT YET RECRUITING Neoadjuvant SBRT Followed by Sintilimab Plus Chemotherapy for N3-Positive NSCLC
Yang Hong
NCT07073365 RECRUITING Bolstering Outcomes After Induction With Osimertinib Plus Chemotherapy Through Optimized Site-Directed Primary Tumor Therapy (BOOST Trial)
Pusan National University Hospital
NCT07247786 NOT YET RECRUITING Study for Evaluating the Safety and Feasibility of Fecal Microbiota Transplant in Stage II-III NSCLC Patients Using ICI Responders as Donors (MIGRANT)
Fundación GECP
NCT07304739 RECRUITING Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases
Tianjin Medical University Cancer Institute and Hospital
NCT02905591 ACTIVE NOT RECRUITING A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC
Joseph J. Cullen, MD, FACS
NCT07146230 NOT YET RECRUITING The Selective Personalized Radio-Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer Trial 2
Montefiore Medical Center
NCT07079475 RECRUITING Study of Oral EGFR Inhibitor DZD6008 Combined With Sunvozertinib in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN8)
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
NCT07117890 RECRUITING Sunvozertinib Treatment in Untreated Advanced NSCLC With EGFR Uncommon Mutations
Fudan University
NCT03381274 ACTIVE NOT RECRUITING Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
MedImmune LLC
NCT07218601 RECRUITING Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT06512051 RECRUITING A Trial of SHR-A2102 With Adebrelimab With or Without Other Antitumor Therapy in Advanced or Metastatic Non-small Cell Lung Cancer
Shanghai Hengrui Pharmaceutical Co., Ltd.
NCT05297890 ACTIVE NOT RECRUITING A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer
CStone Pharmaceuticals
NCT02864992 ACTIVE NOT RECRUITING Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)
EMD Serono Research & Development Institute, Inc.
NCT02638090 ACTIVE NOT RECRUITING Pembro and Vorinostat for Patients With Stage IV Non-small Cell Lung Cancer (NSCLC)
H. Lee Moffitt Cancer Center and Research Institute
NCT07294261 NOT YET RECRUITING Garsorasib In KRAS G12C Mutant Locally Advanced and Metastatic NSCLC
Sun Yat-sen University
NCT07192068 RECRUITING Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.
UNICANCER
NCT04579380 ACTIVE NOT RECRUITING Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
Seagen, a wholly owned subsidiary of Pfizer
NCT06606847 ACTIVE NOT RECRUITING A Study to Investigate the Effects of Durvalumab With Oleclumab Following Chemoradiation in Participants With Locally Advanced Unresectable Non-Small Cell Lung Cancer (LADOGA)
AstraZeneca
NCT04077099 RECRUITING A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
Regeneron Pharmaceuticals
NCT04198766 ACTIVE NOT RECRUITING Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Inhibrx Biosciences, Inc
NCT07171606 RECRUITING A Phase II Study of SSGJ-706 Monotherapy and Combination Therapy in Advanced Non-Small Cell Lung Cancer(NSCLC) Patients
Shenyang Sunshine Pharmaceutical Co., LTD.
NCT04966663 RECRUITING Using ctDNA to Determine Therapies for Lung Cancer
University Health Network, Toronto
NCT04140500 ACTIVE NOT RECRUITING Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
Hoffmann-La Roche
NCT06680050 RECRUITING Phase II Study of Radiotherapy Followed by Durvalumab and Ceralasertib in Stage III NSCLC Patients With Thoracic Relapses +/- Oligometastases After PACIFIC Regimen
Mario Negri Institute for Pharmacological Research
NCT07276789 RECRUITING Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer
Integro Theranostics
NCT06102057 RECRUITING PACCELIO - FDG-PET Based Small Volume Accelerated Immuno Chemoradiotherapy in Locally Advanced NSCLC
TheraOp
NCT05013450 ACTIVE NOT RECRUITING Dupilumab_Metastatic NSCLC
Thomas Marron
NCT07169552 RECRUITING HC010 in First-line PD-L1 Positive Advanced NSCLC Patients
HC Biopharma Inc.
NCT07285148 NOT YET RECRUITING A Study to Evaluate ANS014004 in Combination With EGFR-TKI in Non-Small Cell Lung Cancer
Beijing Pearl Biotechnology Limited Liability Company
NCT07224152 NOT YET RECRUITING NBTXR3 With Radiation Therapy Alone for Locally-advanced Non-small Cell Lung Cancer
M.D. Anderson Cancer Center
NCT07286942 NOT YET RECRUITING Stereotactic Body Radiotherapy With Sequential Iparomlimab and Tuvonralimab (QL1706) + Chemotherapy as Neoadjuvant Therapy in Patients With Resectable Non-small-cell Lung Cancer in China (LUNG-Nanjing01): a Single-arm, Single-centre, Phase 2 Trial
Jiangsu Cancer Institute & Hospital
NCT07283198 NOT YET RECRUITING A Phase II Clinical Study to Evaluate the Safety, Efficacy, Pharmacokinetics/Pharmacodynamics of JSKN033 in Patients With Advanced Non-Small Cell Lung Cancer
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
NCT04609566 ACTIVE NOT RECRUITING Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors
Seagen, a wholly owned subsidiary of Pfizer
NCT04736173 ACTIVE NOT RECRUITING Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
Arcus Biosciences, Inc.
NCT07281209 NOT YET RECRUITING A Study of SHR-A1811 Combined With Adebelimumab as Neoadjuvant Therapy for Resectable HER2-Altered Non-Small Cell Lung Cancer
Shanghai Chest Hospital
NCT03347838 ACTIVE NOT RECRUITING Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers
University of Colorado, Denver
NCT03556228 RECRUITING VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
VM Oncology, LLC
NCT06922591 RECRUITING Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients
Tango Therapeutics, Inc.
NCT06943521 RECRUITING A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Tanabe Pharma America, Inc.
NCT07274761 ACTIVE NOT RECRUITING Neoadjuvant Sunvozertinib in Stage II-IIIB Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutation.
Shanghai Pulmonary Hospital, Shanghai, China
NCT07274384 NOT YET RECRUITING Hyperprogression in PD-L1 ≥ 50% NSCLC: a Biomarker Guided Phase 2 Trial
Università Vita-Salute San Raffaele
NCT05801029 ACTIVE NOT RECRUITING A Study to Investigate Safety and Efficacy of Osimertinib and Amivantamab in Participants With Non-small Cell Lung Cancer With Common Epidermal Growth Factor Receptor Mutations
AstraZeneca
NCT07271602 NOT YET RECRUITING A Phase 2 Randomized, Controlled Trial of QL1706 Plus Chemotherapy and Quad Shot for Driver Gene-negative Advanced Non-small Cell Lung Cancer.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT07224971 RECRUITING Impact of Circadian Rhythm on Immunotherapy
Liza Villaruz, MD
NCT05256290 ACTIVE NOT RECRUITING Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations
Black Diamond Therapeutics, Inc.
NCT06882174 NOT YET RECRUITING This Study is Comparing Morning vs Random Scheduling of Standard of Care Pembrolizumab Checkpoint Inhibitor Immunotherapy Infusions in Patients With Metastatic Non-small Cell Lung Cancer
AHS Cancer Control Alberta
NCT04351256 ACTIVE NOT RECRUITING Thoracic Radiotherapy Plus Durvalumab in Elderly and/or Frail NSCLC Stage III Patients Unfit for Chemotherapy
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT04163432 ACTIVE NOT RECRUITING Staggered, Chemo-Immunotherapy With Durvalumab, MEDI4736 Pemetrexed & Carboplatin (PC) for Metastatic Non-Squamous NSCLC
University of Utah
NCT07256509 NOT YET RECRUITING A Study of SYS6010 Combined With Osimertinib Versus Osimertinib Alone as Neoadjuvant Therapy for Patients With EGFR Mutation-positive Resectable Non-squamous Non-small Cell Lung Cancer
CSPC Megalith Biopharmaceutical Co.,Ltd.
NCT07264816 NOT YET RECRUITING A Study of BL-M07D1 in Combination With Pembrolizumab in Patients With Unresectable Locally Advanced or Metastatic HER2-Overexpressing Non-Squamous NSCLC
Sichuan Baili Pharmaceutical Co., Ltd.
NCT07264647 RECRUITING Neoadjuvant Chemo-immunotherapy for Stage III PD-L1 Positive Non-Small Cell Lung Cancer (NSCLC)
Fondazione Ricerca Traslazionale
NCT07264673 RECRUITING A Randomized Phase II Trial of Cemiplimab Plus OSE2101 ( TEDOPI®) as Maintenance Therapy in ctDNA Positive NSCL. The Cemited Study.
Fondazione Ricerca Traslazionale
NCT07070518 RECRUITING Study of GV20-0251 in Participants With Solid Tumor Malignancies
GV20 Therapeutics
NCT05882513 ACTIVE NOT RECRUITING Serplulimab Combined With Chemotherapy in Patients With Resectable Non-small-cell Lung Cancer
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT07259226 RECRUITING Optimal Methods to Characterize ADC Resistance in Solid Tumors and Identify Clinically Useful Biomarkers
UNICANCER
NCT05751018 RECRUITING Phase II Clinical Study of Pyrotinib in First-line Treatment of Primary HER2-amplified/Mutated Advanced Non-small Cell Lung Cancer
Peking Union Medical College Hospital
NCT07253142 NOT YET RECRUITING A Phase II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Subjects With Advanced Lung Cancer
Shanghai Henlius Biotech
NCT05061550 RECRUITING Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
AstraZeneca
NCT07229729 RECRUITING A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer
Shanghai Hengrui Pharmaceutical Co., Ltd.
NCT07206498 RECRUITING A Study to Evaluate Safety and Efficacy of WSD0922-FU Combo With Osimertinib for NSCLC
Wayshine Biopharm, Inc.
NCT05098132 RECRUITING Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
Synthekine
NCT03999710 ACTIVE NOT RECRUITING Determining Whether Durvalumab in Combination With Radiation Therapy Can Prevent the Progression of Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT04940325 ACTIVE NOT RECRUITING Datopotamab Deruxtecan (Dato-DXd, DS-1062a) in Advanced and/or Unresectable Non-Small Cell Lung Cancer
Gustave Roussy, Cancer Campus, Grand Paris
NCT07132918 RECRUITING HEARTS Trial for Thoracic Cancers
University of Wisconsin, Madison
NCT07058519 RECRUITING A Study of Osimertinib-based Adaptive Treatment Guided by ctDNA EGFRm+ Monitoring in NSCLC
Shanghai Chest Hospital
NCT06107686 RECRUITING A Study of YL202 in Selected Patients With Advanced Solid Tumors
MediLink Therapeutics (Suzhou) Co., Ltd.
NCT07249372 RECRUITING DRP-104 in Patients With NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer
NYU Langone Health
NCT06841055 RECRUITING Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy Following Chemoimmunotherapy
BioNTech SE
NCT03137771 ACTIVE NOT RECRUITING Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer
NRG Oncology
NCT06400160 NOT YET RECRUITING Clinical Trial of TB511 in Advanced Solid Tumors
Twinpig Biolab, Inc.
NCT07241819 NOT YET RECRUITING Ivonescimab Monotherapy or in Combination With Chemotherapy as Neoadjuvant/Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
Peking University Cancer Hospital & Institute
NCT06652048 RECRUITING High-dose Furmonertinib or Combined With Chemotherapy in EGFR-mutant Advanced NSCLC After Disease Progression on Third-generation EGFR-TKI
Jialei Wang
NCT06352008 RECRUITING To Evaluate the Efficacy and Safety of Anlotinib Hydrochloride Capsule in Postoperative Non-pCR Patients With Non-small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT05456256 RECRUITING A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
Lantern Pharma Inc.
NCT05786924 RECRUITING Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Institut de Recherches Internationales Servier
NCT06496490 RECRUITING A Clinical Trial of TQB2102 for Injection in Non-small Cell Lung Cancer With HER2 Gene Abnormality
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
NCT06917573 RECRUITING PALACE: Cemiplimab Trial According to ctDNA Levels
Fundación GECP
NCT07235306 NOT YET RECRUITING Ensartinib After Chemoradiotherapy in Stage III ALK-Mutated NSCLC
Shanghai Pulmonary Hospital, Shanghai, China
NCT05466149 ACTIVE NOT RECRUITING Efficacy and Safety of Furmonertinib in Patients With Locally Advanced or Metastatic NSCLC With EGFR Exon 20 Insertion
Allist Pharmaceuticals, Inc.
NCT06455917 RECRUITING TIL Therapy in Non-small-cell Lung Cancer (NSCLC) Patients
University Hospital, Basel, Switzerland
NCT07153445 RECRUITING Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)
Fundación GECP
NCT07234877 NOT YET RECRUITING A Randomized Phase II Study Evaluating Upfront SRT to All Brain Metastases Followed by Ivonescimab Plus Chemotherapy Versus Upfront Ivonescimab Plus Chemotherapy in Patients With Asymptomatic Active Brain Metastases From NSCLC
European Organisation for Research and Treatment of Cancer - EORTC
NCT07231575 NOT YET RECRUITING Neoadjuvant SBRT and Tislelizumab (Immunotherapy) Plus Anlotinib for Resectable EGFR Wild-type NSCLC
Sun Yat-sen University
NCT07175220 RECRUITING Phase II Clinical Study of SHR2554 Tablets Combined With Other Anti-tumor Treatments in Non-small Cell Lung Cancer Subjects
Jiangsu HengRui Medicine Co., Ltd.
NCT05781308 ACTIVE NOT RECRUITING Combination of Paclitaxel-bevacizumab ± Atezolizumab in Patients With Advanced NSCLC Progressing After Immunotherapy & Chemotherapy
Intergroupe Francophone de Cancerologie Thoracique
NCT04526782 ACTIVE NOT RECRUITING ENCOrafenib With Binimetinib in bRAF NSCLC
Intergroupe Francophone de Cancerologie Thoracique
NCT05887492 RECRUITING Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors
Tango Therapeutics, Inc.
NCT06139419 ACTIVE NOT RECRUITING The Impact of Thymosin α-1 on the Efficacy of Concurrent Chemoradiotherapy Followed by Immunotherpay Consolidation for Locally Advanced NSCLC
Sun Yat-sen University
NCT05200481 ACTIVE NOT RECRUITING Study of Safety and Efficacy of Brigatinib Plus Chemotherapy or Brigatinib Only in Advanced ALK-Positive Lung Cancer (MASTERPROTOCOL ALK)
Intergroupe Francophone de Cancerologie Thoracique
NCT07231068 RECRUITING A Dose-escalation and Dose-expansion Phase I/Phase II Clinical Study of Dositinib Mesylate Tablets (90-1408) in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer With Positive EGFR Mutation
Henan Genuine Biotech Co., Ltd.
NCT04180371 ACTIVE NOT RECRUITING Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
BicycleTx Limited
NCT06542159 RECRUITING Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases
Sun Yat-sen University
NCT06848699 RECRUITING A Phase Ib/II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Patients With Advanced/Metastatic Solid Tumors
Shanghai Henlius Biotech
NCT07208773 RECRUITING A Study of YL201 and Ivonescimab (AK112) in Advanced Solid Tumors
MediLink Therapeutics (Suzhou) Co., Ltd.
NCT06582940 RECRUITING Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis
Sun Yat-sen University
NCT07133425 RECRUITING A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer
M.D. Anderson Cancer Center
NCT04614103 RECRUITING Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
Iovance Biotherapeutics, Inc.
NCT03122717 ACTIVE NOT RECRUITING Osimertinib and Gefitinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer
Dana-Farber Cancer Institute
NCT06246110 RECRUITING A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC
Eikon Therapeutics
NCT05379985 RECRUITING Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Revolution Medicines, Inc.
NCT02696993 ACTIVE NOT RECRUITING Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer
M.D. Anderson Cancer Center
NCT07223424 RECRUITING Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Diwakar Davar
NCT04484142 ACTIVE NOT RECRUITING Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)
Daiichi Sankyo
NCT04410796 RECRUITING Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers
Memorial Sloan Kettering Cancer Center
NCT05117242 ACTIVE NOT RECRUITING Safety and Efficacy Study of GEN1046 as a Single Agent or in Combination With Pembrolizumab for Treatment of Recurrent (Non-small Cell) Lung Cancer
Genmab
NCT06599502 ACTIVE NOT RECRUITING A Phase I/IIa Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD0022 as Monotherapy and in Combination With Anti-cancer Agents in Adult Participants With Tumours Harbouring a KRASG12D Mutation
AstraZeneca
NCT04074967 ACTIVE NOT RECRUITING Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab
Dan Zandberg
NCT04791839 ACTIVE NOT RECRUITING Safety and Efficacy of Zimberelimab (AB122) in Combination With Domvanalimab (AB154) and Etrumadenant (AB928) in Patients With Previously Treated Non-Small Cell Lung Cancer
Washington University School of Medicine
NCT03539536 ACTIVE NOT RECRUITING Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer
AbbVie
NCT03667820 ACTIVE NOT RECRUITING Study of Osimertinib and Stereotactic Ablative Radiation (SABR) in EGFR Mutant NSCLC
University of Texas Southwestern Medical Center
NCT06616766 RECRUITING A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946
Yuhan Corporation
NCT02856893 ACTIVE NOT RECRUITING Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE)
European Organisation for Research and Treatment of Cancer - EORTC
NCT04665206 RECRUITING Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
Vivace Therapeutics, Inc
NCT06558799 ACTIVE NOT RECRUITING LUNAR-4: Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Pembrolizumab for Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC)
NovoCure GmbH
NCT03334617 ACTIVE NOT RECRUITING Phase II Umbrella Study of Novel Anti-cancer Agents in Participants With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy
AstraZeneca
NCT06623656 RECRUITING Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC
Weill Medical College of Cornell University
NCT07111520 RECRUITING A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)
BioNTech SE
NCT05706129 RECRUITING A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
ITM Oncologics GmbH
NCT05987644 RECRUITING Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements
Joshua Palmer
NCT03909334 ACTIVE NOT RECRUITING Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Xiuning Le
NCT03157128 ACTIVE NOT RECRUITING A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
Eli Lilly and Company
NCT04623775 ACTIVE NOT RECRUITING A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Bristol-Myers Squibb
NCT05565417 ACTIVE NOT RECRUITING Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas
Immunitas Therapeutics
NCT04892017 ACTIVE NOT RECRUITING A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors
Deciphera Pharmaceuticals, LLC
NCT06644768 RECRUITING A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations
Daiichi Sankyo
NCT06814496 RECRUITING Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
University of Arizona
NCT03586453 RECRUITING Osimertinib In EGFR Mutant Lung Cancer
Dana-Farber Cancer Institute
NCT04931654 ACTIVE NOT RECRUITING A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
AstraZeneca
NCT04370587 RECRUITING A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
ImmVira Pharma Co. Ltd
NCT06305715 RECRUITING Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)
Medical College of Wisconsin
NCT03915678 RECRUITING Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors
Institut Bergonié
NCT05296564 RECRUITING Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers
Hadassah Medical Organization
NCT05676931 ACTIVE NOT RECRUITING Study With Various Immunotherapy Treatments in Participants With Lung Cancer
Gilead Sciences
NCT05937906 RECRUITING Clinical Trial Evaluating the Safety and Efficacy of Chemoimmunotherapy Plus Short Course of Mek Inhibitor in First Line of Treatment of Metastatic Non Squamous Non Small Cell Lung Adenocarcinoma With PDL1 < 50 %.
Centre Georges Francois Leclerc
NCT07204548 NOT YET RECRUITING The IVO-LUNG Study
Sun Yat-sen University
NCT05299125 ACTIVE NOT RECRUITING Amivantamab, Lazertinib, and Pemetrexed for First-line Treatment of Recurrent/Metastatic Non-small Cell Lung Cancers With Epidermal Growth Factor Receptor Mutations
Latin American Cooperative Oncology Group
NCT05798663 ACTIVE NOT RECRUITING Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC
Alliance Foundation Trials, LLC.
NCT04497584 ACTIVE NOT RECRUITING Phase 2 Trial of Afatinib Plus Prednisone for Advanced Squamous NSCLC
University of Texas Southwestern Medical Center
NCT07202364 NOT YET RECRUITING A Study of YL202 in Patients With Advanced Solid Tumors
MediLink Therapeutics (Suzhou) Co., Ltd.
NCT07200947 NOT YET RECRUITING A Phase II Study of QL1706 and Platinum-Based Chemotherapy in Patients With SMARCA4-Deficient, Locally Advanced or Metastatic Non-Small Cell Lung Cancer.
Zhijie Wang
NCT07181499 RECRUITING Sequential Chemotherapy With Befotertinib in Non-Small Cell Lung Cancer (NSCLC) Patients With Resistance to Third-Generation EGFR-TKI
Betta Pharmaceuticals Co., Ltd.
NCT07122687 RECRUITING IBI363 Combined With Chemotherapy or Pembrolizumab Combined With Chemotherapy as Neoadjuvant Therapy in Resectable Stage IB-III Non-Squamous Non-Small Cell Lung Cancer
Innovent Biologics (Suzhou) Co. Ltd.
NCT07198321 NOT YET RECRUITING A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors
Genfleet Therapeutics (Shanghai) Inc.
NCT07198217 RECRUITING Real World Study of Platinum Containing Dual Drug Chemotherapy Followed by Large Fractionated Radiotherapy Combined withTislelizumab in Stage IIIB/C-IV Non-small Cell Lung Cancer Patient
Zibo Municipal Hospital
NCT06822543 RECRUITING A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)
Latin American Cooperative Oncology Group
NCT05949619 ACTIVE NOT RECRUITING A Study of BL-M02D1 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer or Other Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT07193641 RECRUITING A Study on Using SFRT With Standard Treatment for Oligoprogressive NSCLC
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT05956587 RECRUITING A Study of SI-B003 and BL-B01D1+SI-B003 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT05949606 RECRUITING A Study of SI-B001+SI-B003± Chemotherapy in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
NCT06463665 RECRUITING Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer
Genelux Corporation
NCT06623136 RECRUITING A Study of ES102 in Combination With Toripalimab in Subjects With Advanced Non-small Cell Lung Cancer
Elpiscience (Suzhou) Biopharma, Ltd.
NCT05020457 ACTIVE NOT RECRUITING SI-B001 Combined With Chemotherapy in the Treatment of EGFR/ALK WT Recurrent or Metastatic NSCLC.
Sichuan Baili Pharmaceutical Co., Ltd.
NCT04956640 RECRUITING Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
Eli Lilly and Company
NCT06448572 RECRUITING EXL01 in Combination With Nivolumab for Advanced NSCLC Refractory to Immunotherapy.
University Hospital, Lille
NCT03202940 ACTIVE NOT RECRUITING A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC
Massachusetts General Hospital
NCT07193160 NOT YET RECRUITING Sacituzumab Tirumotecan in Combination With Furmonertinib as Second-line Treatment for EGFR-mutant Advanced or Metastatic NSCLC After Failure of First-line Third-generation EGFR-TKI Therapy
Fudan University
NCT06448910 ACTIVE NOT RECRUITING Cadonilimab(AK104) Plus Concurrent Chemoradiotherapy in Patients With Locally Advanced, Unresectable, Stage III NSCLC
Fudan University
NCT04621188 ACTIVE NOT RECRUITING Lorlatinib After Failure of First-line TKI in Patients With Advanced ROS1-positive NSCLC (ALBATROS)
Intergroupe Francophone de Cancerologie Thoracique
NCT07190027 NOT YET RECRUITING Immunodynamics-Guided Optimization of Individualized Immunochemotherapy in Advanced Driver-Negative NSCLC: A Randomized Trial
First Affiliated Hospital of Wenzhou Medical University
NCT05941897 ACTIVE NOT RECRUITING A Study to Investigate Efficacy and Safety of Ceralasertib Plus Durvalumab in Participants Aged ≥ 18 Years With Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Progressed on or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy
AstraZeneca
NCT05950139 RECRUITING Peptide Vaccine To Prevent Acquired Resistance In Patients With Advanced ALK+ NSCLC
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05880706 ACTIVE NOT RECRUITING A Study of BL-B01D1 and BL-B01D1 in Combination With Osimertinib Mesylate Tablets in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
NCT07182708 NOT YET RECRUITING High-Dose Firmonertinib Plus Bevacizumab as Neoadjuvant Therapy for Resectable EGFRm Stage II-IIIB NSCLC
Peking University Cancer Hospital & Institute
NCT06205706 ACTIVE NOT RECRUITING BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors
BioInvent International AB
NCT06362369 RECRUITING A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
7 Hills Pharma, LLC
NCT06567015 RECRUITING Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs
Pierre Fabre Medicament
NCT07177092 NOT YET RECRUITING Primary Tumor Resection Plus Osimertinib in Advanced EGFR-mutant Non-small Cell Lung Cancer
Jianxing He
NCT03647163 ACTIVE NOT RECRUITING Ph I/II Trial of Systemic VSV-IFNβ-NIS in Combination With Checkpoint Inhibitor Therapy in Patients With Select Solid Tumors
Vyriad, Inc.
NCT07177105 NOT YET RECRUITING Primary Tumor Resection With Sintilimab and Chemotherapy in Advanced NSCLC
Jianxing He
NCT06020066 ACTIVE NOT RECRUITING SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI
Fudan University
NCT07172802 RECRUITING A Study of GI-108, an Anti-CD73-IgG4 Fc-IL-2v Bispecific Fusion Protein, as Monotherapy in Patients With Advanced or Metastatic Solid Tumors
GI Innovation, Inc.
NCT07169994 RECRUITING A Study of YL202 in Combination With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors
MediLink Therapeutics (Suzhou) Co., Ltd.
NCT07167459 ENROLLING BY INVITATION Personalized SBRT in Early-Stage Peripheral NSCLC
Tianjin Medical University Cancer Institute and Hospital
NCT07164170 NOT YET RECRUITING A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Glecirasib
Abbisko Therapeutics Co, Ltd
NCT06865339 RECRUITING Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer
Nitin Ohri
NCT05277844 RECRUITING Local Consolidative Radiation Therapy Plus TKI Versus TKI Alone in Driver Mutated OM-NSCLC
Tata Memorial Hospital
NCT06682793 RECRUITING A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
A2 Biotherapeutics Inc.
NCT04504071 ACTIVE NOT RECRUITING Dacomitinib in Lung Cancer With Uncommon EGFR Mutations
Shanghai Chest Hospital
NCT06262321 RECRUITING Thoracic Radiotherapy for Patients With Metastatic (Stage IV) Non-Small Cell Lung Cancer at High Risk of Symptomatic Progression Within the Thorax
University of Rochester
NCT07158840 NOT YET RECRUITING AK112 in Non-squamous Non-small Cell Lung Cancer (NSCLC)Patients With Actionable Genomic Alterations (AGA) Who Have Failed to Previous Tyrosine Kinase Inhibitor (TKI) Treatment
Akeso
NCT06868485 RECRUITING A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer
Wayshine Biopharm, Inc.
NCT07158489 NOT YET RECRUITING Overcoming Resistance to Immunotherapy Combining Gemcitabine With Ivonescimab in Advanced NSCLC
Swiss Cancer Institute
NCT06127303 RECRUITING Toripalimab Combined With Cryoablation for First-line Oligo-progression in Driver-negative Advanced NSCLC
Shanghai Chest Hospital
NCT07156604 NOT YET RECRUITING Vebreltinib for Neoadjuvant in METex 14 Skipping Mutant Stage IIA-IIIB (N2) Non-small Cell Lung Cancer (NSCLC)
Fudan University
NCT04977453 RECRUITING GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors
GI Innovation, Inc.
NCT05318573 ACTIVE NOT RECRUITING A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer
Fujifilm Pharmaceuticals U.S.A., Inc.
NCT07153770 NOT YET RECRUITING Bozitinib Combined With Chemotherapy as Radical Treatment for Stage IIA-IIIC MET-Altered Non-Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT05773092 ACTIVE NOT RECRUITING A Phase 2 Study of Osimertinib and S-1 in Treatment Resistant EGFR Mutant NSCLC
National Cancer Centre, Singapore
NCT06364917 RECRUITING DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC
University of Alabama at Birmingham
NCT05585320 ACTIVE NOT RECRUITING A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors
Immuneering Corporation
NCT06060613 RECRUITING Safety and Efficacy of OBX-115 in Advanced Solid Tumors
Obsidian Therapeutics, Inc.
NCT06631989 RECRUITING A Study to Assess the Efficacy and Safety of WSD0922-FU in Patients With EGFRm+ Advanced Non-small Cell Lung Cancer
Wayshine Biopharm, Inc.
NCT07070440 RECRUITING DZD6008 Combination Therapy in Patients With Locally Advanced or Metastatic NSCLC With EGFR Mutation (TIAN-SHAN7)
Dizal Pharmaceuticals
NCT05246514 ACTIVE NOT RECRUITING A Single Arm Phase 2 Study to Evaluate Efficacy and Safety of Trastuzumab Deruxtecan for Patients With HER2 Mutant NSCLC
AstraZeneca
NCT05451849 ACTIVE NOT RECRUITING A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
TCR2 Therapeutics
NCT03907852 ACTIVE NOT RECRUITING Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer
TCR2 Therapeutics
NCT07138755 NOT YET RECRUITING The Efficacy and Safety of the Combination of PD-1 With Chemotherapy and Adaptive Radiotherapy Strategy in the Treatment of Stage III Non-small Cell Lung Cancer Patients
The Third Xiangya Hospital of Central South University
NCT04495153 ACTIVE NOT RECRUITING CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
Candel Therapeutics, Inc.
NCT07084610 RECRUITING Metabolic Biomarkers Predicting Response to Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer
Hospital das Clínicas de Ribeirão Preto
NCT07134413 NOT YET RECRUITING QL1706/Bevacizumab ± Chemotherapy in Post-ICI Non-Squamous NSCLC
Guangdong Association of Clinical Trials
NCT05557591 ACTIVE NOT RECRUITING A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1)
Regeneron Pharmaceuticals
NCT07130032 RECRUITING Efficacy And Safety Of Anti-PD-1/PD-L1 Antibodies In Combination With Bevacizumab And Metronomic Cyclophosphamide In Patients With Non-Small Cell Lung Cancer And Cutaneous Melanoma Previously Treated With Immune Checkpoint Blockade
EuroCityClinic LLC
NCT07129161 NOT YET RECRUITING Iparomlimab and Tuvonralimab Combined With 2 or 4 Cycles of Chemotherapy as Neoadjuvant Therapy for Resectable NSCLC
Sun Yat-sen University
NCT05609578 RECRUITING Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Mirati Therapeutics Inc.
NCT06907615 RECRUITING A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
Shanghai Henlius Biotech
NCT05864144 ACTIVE NOT RECRUITING A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Sensei Biotherapeutics, Inc.
NCT03620669 ACTIVE NOT RECRUITING 1st Line Durvalumab in PS 2 NSCLC Patients
Swiss Cancer Institute
NCT04245514 ACTIVE NOT RECRUITING Multimodality Treatment in Stage III Non-small Cell Lung Cancer (NSCLC)
Swiss Cancer Institute
NCT05057013 ACTIVE NOT RECRUITING A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
Cancer Research UK
NCT07039656 RECRUITING Toripalimab Combined With Chemotherapy as Adjuvant Therapy for Non-small Cell Lung Cancer With or Without Prior Neoadjuvant Therapy
Wen-zhao ZHONG
NCT07108816 NOT YET RECRUITING A Single-center, Phase II Clinical Trial Evaluating the Efficacy of Sacituzumab Tirumotecan in Combination With Tagitanlimab as Neoadjuvant Therapy for PD-L1-positive, Resectable Stage II to IIIB Non-small Cell Lung Cancer (NSCLC)
Henan Cancer Hospital
NCT05787613 ACTIVE NOT RECRUITING A Clinical Study to Evaluate the Efficacy and Safety of HLX26 (Anti-LAG-3 Monoclonal Antibody Injection) Combined With Serplulimab and Chemotherapy in Previously Untreated Advanced NSCLC Patients
Shanghai Henlius Biotech
NCT05442060 RECRUITING To Evaluate OBI-833/OBI-821 in Combination With First-Line Erlotinib in Patients With EGFR-Mutated, Globo H-Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer
OBI Pharma, Inc
NCT05403385 ACTIVE NOT RECRUITING Study of Inupadenant (EOS100850) With Chemotherapy as Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer
iTeos Therapeutics
NCT06114511 RECRUITING A Study of BL-M07D1 in Patients With HER2-mutated, Locally Advanced or Metastatic Non-small-cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
NCT06897046 RECRUITING Perioperative Study of Iparomlimab and Tuvonralimab in Resectable NSCLC
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06105021 ACTIVE NOT RECRUITING Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor
Affini-T Therapeutics, Inc.
NCT07014202 RECRUITING Consolidation Radiotherapy vs. Observation in Oligoresidual Advanced Non-Small Cell Lung Cancer After Chemo-Immunotherapy
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05078931 ACTIVE NOT RECRUITING A Study to Evaluate Pembrolizumab Plus Lenvatinib in PD-L1 Positive TKI Resistant NSCLC Patients
Shanghai Chest Hospital
NCT06620835 RECRUITING Trial for Local Ablative Treatment (LAT) Optimization in Patients With Advanced Non-Small Cells Lung Cancer (NSCLC) Presenting an Anaplastic Lymphoma Kinase (ALK) Rearrangement Treated by Brigatinib
Groupe Francais De Pneumo-Cancerologie
NCT06015724 RECRUITING Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer
Georgetown University
NCT07089199 NOT YET RECRUITING Tislelizumab Combined With Anlotinib and Nab-paclitaxel in III Resectable Non-small Cell Lung Cancer(TitAN) : A Prospective, Single-Arm, Phase II Study
Qilu Hospital of Shandong University
NCT06864624 RECRUITING Perioperative Treatment of Sunvozertinib in Stage II-IIIB NSCLC
Tang-Du Hospital
NCT07086326 NOT YET RECRUITING A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLC
Yang Fan, MD
NCT07063329 NOT YET RECRUITING Phase I/II Study of PLB1004 Combined With Platinum-based Doublet Chemotherapy in Patients With EGFR Mutation-positive
Avistone Pharmaceutical(Ningbo)Co., LTD.
NCT07085182 RECRUITING Tislelizumab Combined With sCRT in Stage IIIB/C-IV Non-Squamous Non-Small Cell Lung Cancer:A Prospective, Single-Arm, Phase II Study
Zibo Municipal Hospital
NCT07087223 RECRUITING Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure
Peking University Cancer Hospital & Institute
NCT07086456 RECRUITING Combination of Concurrent Chemoradiotherapy With Surufatinib and Tislelizumab in Patients With Locally Advanced Non-Small Cell Lung Cancer
Sun Yat-sen University
NCT06062823 RECRUITING Study of EGFR TKI in Patients With Advanced NSCLC Harbouring EGFR Mutations
National University Hospital, Singapore
NCT06579196 RECRUITING Trabedersen (OT-101) With Pembrolizumab for Newly Diagnosed Advanced NSCLC and Positive PD-L1
University of Nebraska
NCT07001618 NOT YET RECRUITING Oral Pooled Fecal Microbiotherapy (MaaT033) Concomitant to Cemiplimab Versus Best Investigator's Choice in Patients With Resistance to Treatment Due to Antibiotics Uptake With Advanced Non-small Cell Lung Cancer
Gustave Roussy, Cancer Campus, Grand Paris
NCT05894889 ACTIVE NOT RECRUITING Pembrolizumab and Chemotherapy Neoadjuvant/Adjuvant of NSCLC
Peking University
NCT06951464 RECRUITING A Study of BL-B01D1 and Almonertinib in Patients With Resectable EGFR+ Stage II-IIIB NSCLC
Sichuan University
NCT04136535 RECRUITING Pemetrexed and Carboplatin With or Without Anlotinib Hydrochloride for Osimertinib-resistant Non-squamous NSCLC
Fudan University
NCT06902272 RECRUITING ctDNA to Predict Response to Chemo-Immunotherapy and Detect Minimal Residual Disease in Non-Small Cell Lung Cancer
University of Miami
NCT07076914 NOT YET RECRUITING Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
NCT06947694 RECRUITING A Study on Exploring the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases
Xinqiao Hospital of Chongqing
NCT06951399 NOT YET RECRUITING Tracking T-Cell Responses to Evaluate Pembrolizumab Effectiveness in Advanced Non-Small Cell Lung Cancer
Rabin Medical Center
NCT06895031 RECRUITING Study of JYP0015 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Guangzhou JOYO Pharma Co., Ltd
NCT05543330 RECRUITING A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC
Wuhan YZY Biopharma Co., Ltd.
NCT06709859 RECRUITING Afatinib Combined With Chemotherapy as Conversion Therapy in Unresectable EGFR Sensitive Mutation-positive Stage III NSCLC
Shandong Public Health Clinical Center
NCT06962865 RECRUITING A Phase Ⅱ Study of RC108 in Combination With Furmonertinib for the First-line Treatment of EGFR-Mutated Combined MET-Positive Unresectable Locally Advanced or Recurrent Metastatic NSCLC
RemeGen Co., Ltd.
NCT03148327 ACTIVE NOT RECRUITING Astra Zeneca (Immuno Stereotactic Ablative Body Radiotherapy) ISABR Study: Randomized Phase I/II Study of Stereotactic Body Radiotherapy
Jonsson Comprehensive Cancer Center
NCT06617936 RECRUITING Tislelizumab Combined With Recombinant Human Endostatin Combined With Chemotherapy for Unresectable Stage III Non-small Cell Lung Cancer.
Hua Zhang
NCT06953843 RECRUITING Study on the Optimal Combination Pattern of the Combined Treatment of Radiotherapy and Immunotherapy for the Abscopal Effect in Non-Small Cell Lung Cancer (NSCLC) With Multiple Metastases
Xinqiao Hospital of Chongqing
NCT07064018 RECRUITING Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies
University of California, Irvine
NCT06975293 RECRUITING STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers
STORM Therapeutics LTD
NCT06379087 RECRUITING Radiation Therapy Followed by Tislelizumab and Anlotinib Aeoadjuvant/Adjuvant Therapy for Stage II-IIIA NSCLC
Ji Yongling
NCT05086692 RECRUITING A Beta-only IL-2 ImmunoTherapY Study
Medicenna Therapeutics, Inc.
NCT07037680 RECRUITING Radiotherapy Plus Anlotinib in LA-NSCLC Intolerable to cCRT
JIANYANG WANG
NCT04062708 ACTIVE NOT RECRUITING CHIO3 Trial: CHemotherapy Combined With Immune Checkpoint Inhibitor for Operable Stage IIIA/B Non-Small Cell Lung Cancer
Alliance Foundation Trials, LLC.
NCT06969027 RECRUITING JS207Combined With Chemotherapy in First-line Treatment of Advanced NSCLC
Shanghai Junshi Bioscience Co., Ltd.
NCT05286294 ACTIVE NOT RECRUITING Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders
Oslo University Hospital
NCT03093688 RECRUITING Clinical Safty and Efficacy Study of Infusion of iNKT Cells and CD8+T Cells in Patients With Advanced Solid Tumor
Shanghai Public Health Clinical Center
NCT07043907 NOT YET RECRUITING PANK-003 Cell Injection Combined With Standard Adjuvant Chemotherapy After Surgery in Patients With Stage IIIA NSCLC
Shenzhen Celconta Life Science Co., Ltd.
NCT06977828 NOT YET RECRUITING A Prospective, Single-arm, Phase II Clinical Study of Tislelizumab Combined With Anlotinib and Platinum-based Doublet Perioperative Therapy for Resectable Stage II-IIIB Driver Gene-negative NSCLC
The First Affiliated Hospital with Nanjing Medical University
NCT06385262 RECRUITING TOP 2301: Neoadjuvant Chemo for NSCLC
Duke University
NCT03175224 RECRUITING APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Apollomics Inc.
NCT06868836 RECRUITING A Study of JS207 (PD-1/VEGF Bispecific Antibody) in Combination With Chemotherapy in Advanced Non-small Cell Lung Cancer
Shanghai Junshi Bioscience Co., Ltd.
NCT07038460 NOT YET RECRUITING A Multicenter Phase II Randomized Trial of Limertinib Followed by Sintilimab and Chemotherapy vs. Limertinib Followed by Limertinib and Chemotherapy as Neoadjuvant Therapy in Resectable Stage II-IIIB EGFR-Mutant NSCLC
Wen-zhao ZHONG
NCT05589818 RECRUITING Pembrolizumab for Advanced NSCLC and PS 2-3
Icahn School of Medicine at Mount Sinai
NCT07035392 NOT YET RECRUITING Adebrelimab + Chemotherapy as Neoadjuvant Therapy for Resectable NSCLC
Zhangzhou Municipal Hospital
NCT07034391 RECRUITING A Study Evaluating the Efficacy of PD-1 Inhibitor Combined With Denosumab and Chemotherapy in Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Patients With Driver Gene-Negative Status
China Medical University, China
NCT07031154 NOT YET RECRUITING A Single-arm, Multicenter, Prospective Clinical Study of Adebrelimab Combined With Apatinib Neoadjuvant Therapy for Resectable Non-small Cell Lung Cancer
The First Affiliated Hospital of Xiamen University
NCT05910827 RECRUITING Study of an Anti-HER3 Antibody, HMBD-001, With Docetaxel +/- Cetuximab in Advanced Squamous Non-small Cell Lung Cancers, and HMBD-001 + Cetuximab in Advanced Squamous Cell Cancers
Hummingbird Bioscience
NCT06239194 RECRUITING Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
ModeX Therapeutics, An OPKO Health Company
NCT04699188 ACTIVE NOT RECRUITING Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals
NCT03645928 RECRUITING Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
Iovance Biotherapeutics, Inc.
NCT06276283 RECRUITING DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29)
Dizal Pharmaceuticals
NCT06205927 RECRUITING Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer
Jian Chen
NCT04905316 ACTIVE NOT RECRUITING A Study of Canakinumab With Chemotherapy, Radiation Therapy, and Durvalumab in People With Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT05180799 ACTIVE NOT RECRUITING A Phase 1/2 Study of BA3071 in Patients With Solid Tumors
BioAtla, Inc.
NCT06311981 RECRUITING Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients
Jian Chen
NCT05460273 ACTIVE NOT RECRUITING A Study of Dato-DXd in Chinese Patients With Advanced Non-Small Cell Lung Cancer, Triple-negative Breast Cancer and Other Solid Tumors (TROPION-PanTumor02)
AstraZeneca
NCT05613452 RECRUITING Carbon Ion Therapy for Peripheral Non-small Cell Lung Cancer
Shanghai Proton and Heavy Ion Center
NCT05319574 ACTIVE NOT RECRUITING SBRT Followed by Neoadjuvant Immunochemotherapy in Resectable Stage II to III Non-small Cell Lung Cancer
Sun Yat-sen University
NCT05765877 RECRUITING Neoadjuvant WX-0593 in Resectable ALK-positive or ROS1-positive Non-small Cell Lung Cancer
Pingping Song
NCT04027647 ACTIVE NOT RECRUITING Phase 2 Study of Dacomitinib in NSCLC
National Cancer Centre, Singapore
NCT04946968 ACTIVE NOT RECRUITING Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers
National Cancer Centre, Singapore
NCT07014215 NOT YET RECRUITING PD-1 Combined With Bevacizumab and PCSK-9 Inhibitor in Patients With Advanced NSCLC Who Have Progressed After Anti- PD- 1/L1 Therapy
Anhui Provincial Cancer Hospital
NCT06929936 RECRUITING Trilaciclib in Combination With Docetaxel for Second-Line and Beyond Treatment of Locally Advanced or Metastatic NSCLC
The First Affiliated Hospital of Xiamen University
NCT07001995 NOT YET RECRUITING Limertinib Plus Carboplatin and Etoposide for EGFR-mutant NSCLC With SCLC Transformation After EGFR-TKI Progression
Hunan Province Tumor Hospital
NCT06943820 RECRUITING AK129 Combination Therapy for Advanced Solid Tumors
Akeso
NCT06998719 NOT YET RECRUITING Neoadjuvant Durvalumab and Chemotherapy Followed by Surgery/CRT and Durvalumab in Borderline Resectable Stage III NSCLC
Bi Nan
NCT05024214 RECRUITING Phase Ib/II Trial of Envafolimab Plus Lenvatinib for Subjects With Solid Tumors
3D Medicines (Sichuan) Co., Ltd.
NCT03970746 ACTIVE NOT RECRUITING Safety, Immunogenicity and Preliminary Clinical Activity Study of PDC*lung01 Cancer Vaccine in NSCLC
PDC*line Pharma SAS
NCT06992739 NOT YET RECRUITING Trilaciclib in Patients Receiving Sacituzumab Tirumotecan for EGFR-mutated, Advanced Non-Small Cell Lung Cancer (NSCLC)
The First Affiliated Hospital of Xiamen University
NCT04043195 ACTIVE NOT RECRUITING Nivolumab and Ipilimumab in Combination With Immunogenic Chemotherapy for Patients With Advanced NSCLC
Hatim Husain
NCT06424067 RECRUITING Phase 2 Study of Fingolimod in Lung Cancers
Medical University of South Carolina
NCT04140526 ACTIVE NOT RECRUITING Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
OncoC4, Inc.
NCT05825625 ACTIVE NOT RECRUITING NeoTRACK - Dissection of IO Efficacy in NSCLC by Longitudinal tracKing
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT02314481 ACTIVE NOT RECRUITING Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity
University College, London
NCT04789486 RECRUITING Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer
Dana-Farber Cancer Institute
NCT06977074 RECRUITING PROPHET Study: ctDNA-Guided Personalized Induction Immunochemotherapy for NSCLC
Sun Yat-sen University
NCT02664935 ACTIVE NOT RECRUITING National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer
University of Birmingham
NCT06982924 NOT YET RECRUITING A Clinical Study on the Efficacy and Safety of the Combination of Limertinib and Bevacizumab Versus Limertinib as First-line Treatment for NSCLC.
Shanghai Chest Hospital
NCT04152499 ACTIVE NOT RECRUITING Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)
Klus Pharma Inc.
NCT05955391 ACTIVE NOT RECRUITING TGRX-326 Chinese Phase II for Advanced Non-small Cell Lung Cancer (NSCLC)
Shenzhen TargetRx, Inc.
NCT05375994 ACTIVE NOT RECRUITING Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Verastem, Inc.
NCT05742607 RECRUITING IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)
Innate Pharma
NCT05394831 RECRUITING A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC
J Ints Bio
NCT06974370 NOT YET RECRUITING Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial
University of Vermont Medical Center
NCT06971406 NOT YET RECRUITING High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal Metastasis
Qiming Wang
NCT06940401 RECRUITING JS111 in Patients With Advanced NSCLC Harboring EGFR Mutations
Suzhou Junjing BioSciences Co., Ltd.
NCT05144698 RECRUITING RAPA-201 Therapy of Solid Tumors
Rapa Therapeutics LLC
NCT04210492 RECRUITING Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer
Yale University
NCT04699123 ACTIVE NOT RECRUITING The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer
Yale University
NCT05631249 RECRUITING Sotorasib in Previously Treated Locally Advanced or Metastatic NSCLC Subjects With Mutated KRAS p.G12C
Gustave Roussy, Cancer Campus, Grand Paris
NCT06322108 RECRUITING Assessment of the Safety and Efficacy of Balstilimab in Combination With Botensilimab for the Treatment of Non-Small Cell Lung Cancer (IMMONC0008)
Immune Oncology Research Institute
NCT06088771 RECRUITING Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC
Icahn School of Medicine at Mount Sinai
NCT06962189 NOT YET RECRUITING The Efficacy and Safety of Sintilimab Plus Chemotherapy in Surgical Conversion for Patients With Unresectable Stage IIIB-IIIC NSCLC: A Prospective, Single-Arm, Phase II Study
Zhejiang University
NCT06498986 RECRUITING A Study of BL-B01D1 in Combination With Osimertinib Mesylate Tablets in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
NCT06401824 RECRUITING Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases
Maastricht University Medical Center
NCT04317534 RECRUITING Adjuvant Pembrolizumab vs Observation Following Curative Resection for Stage I Non-small Cell Lung Cancer (NSCLC) With Primary Tumors Between 1-4 cm
Greg Durm, MD
NCT05713006 RECRUITING Alectinib Pharmacokinetic in Patients With NSCLC
Instituto Nacional de Cancerologia de Mexico
NCT06951646 NOT YET RECRUITING ctDNA-MRD Guided Escalation of Ivonescimab and Docetaxel in Advanced NSCLC With Long-Term Responses to First-line Immunotherapy (CR1STAL-Adaptive)
Second Xiangya Hospital of Central South University
NCT05994131 RECRUITING IN10018 Combination Therapy in Advanced EGFR Mutation-positive NSCLC
InxMed (Shanghai) Co., Ltd.
NCT04767009 RECRUITING SBRT for Oligo-residual NSCLC After Treatment With PD-1/PD-L1 Immune Checkpoint Inhibitors
Fudan University
NCT02912949 ACTIVE NOT RECRUITING A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)
Partner Therapeutics, Inc.
NCT05168566 RECRUITING Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer
Teligene US
NCT05920135 ACTIVE NOT RECRUITING First-in-Human Study of BBT-207 in Advanced Non-Small Cell Lung Cancer Harboring EGFR Mutation After Treatment With EGFR TKI
Bridge Biotherapeutics, Inc.
NCT06946836 NOT YET RECRUITING Comparison of Neoadjuvant Cadonilimab Versus Chemotherapy Combined With PD-1 in the Treatment of Resectable Non-Small Cell Lung Cancer With High PD-L1 Expression: A Single-Center, Randomized, Exploratory Clinical Study
Shanghai Pulmonary Hospital, Shanghai, China
NCT05736731 ACTIVE NOT RECRUITING A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression
A2 Biotherapeutics Inc.
NCT06945705 RECRUITING A Clinical Trial of Furmonertinib Combined With Anlotinib as First-line Treatment for Advanced NSCLC With EGFR-sensitive Mutations and Brain Metastasis
Henan Cancer Hospital
NCT06944470 NOT YET RECRUITING JS207 Combined With Chemotherapy in Subjects With Stage II-III NSCLC
Shanghai Junshi Bioscience Co., Ltd.
NCT03476681 RECRUITING Study of NEO-201 in Solid Tumors Expansion Cohorts
Precision Biologics, Inc
NCT06939127 RECRUITING Cryoablation Combined With Tislelizumab and Chemotherapy as Neoadjuvant and Adjuvant Therapy in Resectable Stage II-IIIB NSCLC
Tianjin Medical University Cancer Institute and Hospital
NCT06099782 ACTIVE NOT RECRUITING A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)
Merck Sharp & Dohme LLC
NCT06754930 RECRUITING A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With NSCLC
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT06925048 NOT YET RECRUITING SHR0302 Combined With PD-1/PD-L1 Inhibition for Treatment naïve or Acquired Resistant to Immunology NSCLC
Chunxia Su
NCT03916627 ACTIVE NOT RECRUITING Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients
Regeneron Pharmaceuticals
NCT05398094 RECRUITING Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy
Fundación GECP
NCT05684276 RECRUITING DUMAS: Neo-Adjuvant Immunotherapy for Pancoast Tumors
Fundación GECP
NCT05012254 ACTIVE NOT RECRUITING Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases
Fundación GECP
NCT03838159 ACTIVE NOT RECRUITING NADIM II: Neo-Adjuvant Immunotherapy
Fundación GECP
NCT04776447 ACTIVE NOT RECRUITING Atezolizumab Plus Induction Chemotherapy Plus CT-radiotherapy. (APOLO)
Fundación GECP
NCT03313804 ACTIVE NOT RECRUITING Priming Immunotherapy in Advanced Disease With Radiation
John L. Villano, MD, PhD
NCT05800587 RECRUITING Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer
Fox Chase Cancer Center
NCT05288205 RECRUITING Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation
Allist Pharmaceuticals, Inc.
NCT05009329 ACTIVE NOT RECRUITING A Study of JAB-21822 in Adult Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation in China
Allist Pharmaceuticals, Inc.
NCT05276726 RECRUITING A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1
Allist Pharmaceuticals, Inc.
NCT06908733 NOT YET RECRUITING Integrating Surgery and Radiotherapy Following Tislelizumab-based Conversion Therapy in N3-Stage III NSCLC
Liaoning Cancer Hospital & Institute
NCT05756972 ACTIVE NOT RECRUITING A Study of PM8002 (Anti-PD-L1/VEGF) in Combination With Chemotherapy in Patients With NSCLC
Biotheus Inc.
NCT04969315 RECRUITING TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors
Portage Biotech
NCT06221670 RECRUITING Toripalimab Therapy After Resection in High-risk Stage IA2-IB NSCLC With no Driver Alterations (EGFR or ALK)
Tianjin Medical University Cancer Institute and Hospital
NCT06690216 ENROLLING BY INVITATION Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors
Man Hu
NCT05473156 RECRUITING A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients with Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected Malignancies
AP Biosciences Inc.
NCT06896890 RECRUITING Cisplatin (CIS) Administered As Dry Powder for Inhalation (DPI) in Patients with Stage IV Non-Small Cell Lung Cancer
Inhatarget Therapeutics
NCT05798845 RECRUITING The Effect of Toripalimab Plus Radiotherapy in Patients With Operable Stage II-IIIA (N+) Non Small Cell Lung Cancer
Shanghai Chest Hospital
NCT06010329 RECRUITING A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC
Teligene US
NCT06890182 NOT YET RECRUITING Firmonertinib Combined With Chemotherapy as Neoadjuvant Therapy for Resectable Stage Ⅱ-ⅢB EGFR Sensitive Mutanted NSCLC
Tianjin Medical University Cancer Institute and Hospital
NCT06885840 NOT YET RECRUITING Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification.
Betta Pharmaceuticals Co., Ltd.
NCT06844474 RECRUITING A Phase II Clinical Study of SHR-1826 for Injection in Patients With NSCLC
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT04585035 ACTIVE NOT RECRUITING Study to Evaluate D-1553 in Subjects With Solid Tumors
InventisBio Co., Ltd
NCT04036682 ACTIVE NOT RECRUITING A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer
Cullinan Therapeutics Inc.
NCT04836728 ACTIVE NOT RECRUITING Phase II Study of Chemotherapy and PD-1 Inhibitor Combination With Autologous CIK Cell Immunotherapy to Treat Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT05215067 ACTIVE NOT RECRUITING A Phase II Trial of AK104 in Advanced Non-Small Cell Lung Cancer
Akeso
NCT05807048 RECRUITING Daratumumab in STK11 Mutated NSCLC
NYU Langone Health
NCT06863506 RECRUITING Phase II Clinical Study of Befotertinib in EGFR Non-classical Mutant NSCLC
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT05933265 RECRUITING Study of LP-184 in Patients With Advanced Solid Tumors
Lantern Pharma Inc.
NCT04777084 RECRUITING The Efficacy and Safety of the Bispecific Anti-PD-1/PD-L1 Antibody IBI318 Combined with Lenvatinib in NSCLC.
Hunan Province Tumor Hospital
NCT06851169 NOT YET RECRUITING This is a Two-cohort, Exploratory Clinical Study Assessing the Activity of Benmelstobart Alone or Combined with Anlotinib Administered Prior to Surgery in Terms of Pathological Complete Response
Tang-Du Hospital
NCT05669846 RECRUITING Study of Healthy Donor FMT (hdFMT) and Pembrolizumab in Relapsed/Refractory (R/R) PD-L1 Positive NSCLC
Diwakar Davar
NCT06849167 RECRUITING Immunotherapy Combined with Hypofractionated Concurrent Chemoradiotherapy Followed by Immunotherapy in LA-NSCLC
Peking University Cancer Hospital & Institute
NCT04165330 ACTIVE NOT RECRUITING Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors
Sarcoma Oncology Research Center, LLC
NCT06731413 RECRUITING Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)
Virginia Commonwealth University
NCT05281406 RECRUITING Additional Chemotherapy for EGFRm Patients with the Continued Presence of Plasma CtDNA EGFRm At Week 3 After Start of Osimertinib 1st-line Treatment (PACE-LUNG)
Goethe University
NCT06837948 NOT YET RECRUITING Neoadjuvant Chemotherapy Combined With Bispecific Antibody Versus Monoclonal Antibody in Locally Advanced NSCLC
Shanghai Pulmonary Hospital, Shanghai, China
NCT05215548 ACTIVE NOT RECRUITING Primary Tumor Resection With EGFR TKI for Stage IV NSCLC
National Taiwan University Hospital
NCT05599789 ACTIVE NOT RECRUITING Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004)
Peking Union Medical College Hospital
NCT04616209 RECRUITING Allogeneic PB103 (NK Cells) Therapy in Non-small Cell Lung Cancer (NSCLC) Patients
Precision Biotech Taiwan Corp.
NCT05669430 RECRUITING A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies
GV20 Therapeutics
NCT04786093 ACTIVE NOT RECRUITING Durvalumab and Stereotactic Radiotherapy for Advanced NSCLC
University of Texas Southwestern Medical Center
NCT06714708 RECRUITING Low Dose Radiotherapy Combined With Sintilimab and Chemotherapy as Neoadjuvant Therapy for Stage II-III NSCLC
Anhui Provincial Cancer Hospital
NCT04114136 RECRUITING Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
Dan Zandberg
NCT06812871 RECRUITING High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis
Sun Yat-sen University
NCT04258033 ACTIVE NOT RECRUITING A Study of PLB1001 in Non-small Cell Lung Cancer With c-Met Dysregulation(KUNPENG)
Beijing Pearl Biotechnology Limited Liability Company
NCT05431270 RECRUITING Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)
Phanes Therapeutics
NCT03433469 ACTIVE NOT RECRUITING Osimertinib in Treating Participants With Stage I-IIIA EGFR-mutant Non-small Cell Lung Cancer Before Surgery
University of California, San Francisco
NCT03944772 ACTIVE NOT RECRUITING Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)
AstraZeneca
NCT03526835 RECRUITING A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Merus B.V.
NCT06630611 RECRUITING Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL)
Vall d'Hebron Institute of Oncology
NCT04902872 ACTIVE NOT RECRUITING Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors
Cybrexa Therapeutics
NCT06758557 RECRUITING A Study to Evaluate the Safety and Efficacy of HB0025 Injection in Patients With Advanced Solid Tumor
Huabo Biopharm Co., Ltd.
NCT06071013 RECRUITING Nintedanib Plus EGFR TKI In EGFR-mutated Non-small Cell Lung Cancer Patients
China Medical University Hospital
NCT06775743 NOT YET RECRUITING ORIENT-31 Regimen in Combination with SBRT for EGFR-mutant Metastatic NSCLC After First-line Third-generation EGFR-TKIs
Fudan University
NCT04123379 ACTIVE NOT RECRUITING Neoadjuvant Nivolumab with CCR2/5-inhibitor or Anti-IL-8) for Non-small Cell Lung Cancer (NSCLC) or Hepatocellular Carcinoma (HCC)
Icahn School of Medicine at Mount Sinai
NCT06779539 NOT YET RECRUITING Neoadjuvant Ensartinib in ALK Positive Resectable Stage II to III Non-Small Cell Lung Cancer
West China Hospital
NCT06780839 NOT YET RECRUITING Adjuvant Treatment of ALK-positive Non-small Cell Lung Cancer with Ensartinib Guided by MRD
Peking University Cancer Hospital & Institute
NCT06667167 RECRUITING First Line Therapy for Extensive SCLC Patients, Treated with Chemo+Keytruda Followed by Keytuda+Trodelvy
Nir Peled
NCT06775483 NOT YET RECRUITING Evaluation of JSKN016 in the Treatment of Advanced Non-small Cell Lung Cance: a Phase II Clinical Study
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
NCT06581419 RECRUITING A Clinical Trial to Evaluate Effect of IAP0971 in Patients With Advanced Malignant Tumors
SUNHO(China)BioPharmaceutical CO., Ltd.
NCT06772610 NOT YET RECRUITING The Efficacy and Safety of Ensartinib As Adjuvant Therapy in Stage I ALK-positive NSCLC Patients with High Risk Factors
Shanghai Pulmonary Hospital, Shanghai, China
NCT06422403 RECRUITING A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers
National University Hospital, Singapore
NCT04440735 ACTIVE NOT RECRUITING A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors
Kahr Medical
NCT06090266 RECRUITING A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents
OncoResponse, Inc.
NCT06755684 RECRUITING Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer
Peng Zhang
NCT05417321 RECRUITING A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors
Shanghai Huaota Biopharmaceutical Co., Ltd.
NCT06751901 RECRUITING Neoantigen-based Peptide Vaccine, PD-1 Inhibitor, and Radiotherapy for Advanced NSCLC Progressed After Second-line Treatment
The First Affiliated Hospital of Nanchang University
NCT06672068 NOT YET RECRUITING A Study of TY-9591 With Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor NSCLC
TYK Medicines, Inc
NCT05712902 ACTIVE NOT RECRUITING Sunvozertinib (DZD9008) in Pretreated Lung Cancer Patients with EGFR Exon20 Insertion Mutation (WU-KONG6)
Dizal Pharmaceuticals
NCT06751849 RECRUITING Neoantigen-loaded DC Vaccine, PD-1 Inhibitor, and Radiotherapy for Advanced NSCLC Progressed After Second-line Treatment
The First Affiliated Hospital of Nanchang University
NCT06752408 NOT YET RECRUITING Aumolertinib Versus Osimertinib As First-line Therapy for Patients with EGFR Mutated Locally Advanced or Metastatic Non-small-cell Lung Cancer
Peking Union Medical College Hospital
NCT06747169 NOT YET RECRUITING Efficacy and Safety of Sintilimab Combined with Nab-PP Plus Rh-endostatin in Locally Advanced/advanced and Recurrent Metastatic Squamous Non-small Cell Lung Cancer: a Single-arm, Multicenter Clinical Study
Jian-Guo Zhou, MD, PhD
NCT06746870 NOT YET RECRUITING A Phase II Clinical Study to Evaluate the Safety, Pharmacokinetic Profile, and Preliminary Efficacy of IMM2510 in Combination with Chemotherapy As First-line Treatment in Subjects with Non-small Cell Lung Cancer or Triple-negative Breast Cancer
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
NCT06403111 RECRUITING FMT+Immunotherapy+Chemotherapy As First-line Treatment for Driver-gene Negative Advanced NSCLC
Changzhou No.2 People's Hospital
NCT06532591 RECRUITING Neoadjuvant/Adjuvant Cadonilimab Plus Chemotherapy in Patients With Resectable PD-L1 Negative NSCLC
Sichuan Cancer Hospital and Research Institute
NCT05877430 RECRUITING Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
CJ Bioscience, Inc.
NCT06281678 RECRUITING A Study of IBI363 in Subjects with Advanced Solid Malignancies
Innovent Biologics (Suzhou) Co. Ltd.
NCT06467617 RECRUITING Adebrelimab Plus Chemo and Recaticimab in Perioperative Treatment of Resectable NSCLC
Beijing Chest Hospital, Capital Medical University
NCT06734182 RECRUITING Neoadjuvant Envafolimab Plus Disitamab Vedotin and Carboplatin in Resectable HER2-Mutant Non-Small-Cell Lung Cancer
Guangdong Provincial People's Hospital
NCT06668103 RECRUITING A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Firmonertinib
Abbisko Therapeutics Co, Ltd
NCT06728852 RECRUITING Efficacy and Safety of Vorolanib Monotherapy As Third-line or Later Treatment for Advanced Non-small Cell Lung Cancer Patients: a Single-arm, Prospective, Open-label Phase II Clinical Study
Li-kun Chen
NCT06728865 RECRUITING Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study
Li-kun Chen
NCT06706219 NOT YET RECRUITING Efficacy and Safety of SKB264 in Combination With Pembrolizumab in Patients With Initially Unresectable Stage III NSCLC
Hunan Province Tumor Hospital
NCT06724263 NOT YET RECRUITING A Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Malignant Solid Tumors
Tasly Biopharmaceuticals Co., Ltd.
NCT05361174 RECRUITING A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
Iovance Biotherapeutics, Inc.
NCT05000710 ACTIVE NOT RECRUITING Concomitant Radiotherapy, Tremelimumab & Durvalumab for Advanced NSCLC Patients Progressing on First-line Immunotherapy
Sheba Medical Center
NCT06718309 RECRUITING Chemotherapy Plus Immunotherapy Combined With SBRT as Neoadjuvant Therapy for Patients With Resectable NSCLC
First People's Hospital of Hangzhou
NCT06206850 RECRUITING Neo-Bio-ADAURA: a Phase II Study to Evaluate Mechanisms of Resistance to Neoadjuvant Osimertinib
Jair Bar, M.D., Ph.D.
NCT06173505 RECRUITING Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC
Xencor, Inc.
NCT05758116 RECRUITING Tislelizumab Consolidation Therapy After Radiotherapy or Sequential Chemoradiation in Locally Advanced NSCLC Patients
Peking University Cancer Hospital & Institute
NCT06706713 RECRUITING Study of BEBT-109 in Subjects With EGFR Exon 20 Insertion Mutations Non-Small Cell Lung Cancer
BeBetter Med Inc
NCT05128487 ACTIVE NOT RECRUITING A Study of NDI 1150-101 in Patients With Solid Tumors
Nimbus Saturn, Inc.
NCT06702826 RECRUITING Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases
Rongrong Zhou
NCT06700421 ACTIVE NOT RECRUITING Phase II Clinical Study of Adebrelimab Combined with Apatinib in the Treatment of Locally Advanced Non-small Cell Lung Cancer Patients with Radiation Pneumonitis
Wei Zhou
NCT04699721 ACTIVE NOT RECRUITING Clinical Study of Neoadjuvant Chemotherapy and Immunotherapy Combined With Probiotics in Patients With Resectable NSCLC
Xiangya Hospital of Central South University
NCT05948813 RECRUITING TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases
TYK Medicines, Inc
NCT06697990 NOT YET RECRUITING Cerebrospinal Fluid Immune Microenvironment Mechanism in Anaplastic Lymphoma Kinase Positive Lung Cancer Patients
Tianjin Medical University Cancer Institute and Hospital
NCT06632262 RECRUITING A Phase 2 Clinical Study of ABSK061 and ABSK043
Abbisko Therapeutics Co, Ltd
NCT06269211 RECRUITING Neoadjuvant Toripalimab for Clinically Stage II-IIIB Resectable Non-small Cell Lung Cancer with EGFR Mutation and PD-L1 Positive Expression
Ruijin Hospital
NCT04787042 RECRUITING Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
Simcha IL-18, Inc.
NCT06683703 NOT YET RECRUITING Utidelone Injection Combined with Bevacizumab Injection for Non-small Cell Lung Cancer Patients with Brain Metastases
Beijing Biostar Pharmaceuticals Co., Ltd.
NCT06684873 NOT YET RECRUITING A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)
Sun Yat-sen University
NCT06682884 NOT YET RECRUITING Lorlatinib as Neoadjuvant Treatment in Stage IB-IIIB ALK-rearranged Non-Small Cell Lung Cancer
Peking University People's Hospital
NCT06589778 RECRUITING A Study of SHR-A2102 in Combination With Adebrelimab and SHR-8068 in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Shanghai Hengrui Pharmaceutical Co., Ltd.
NCT06388031 RECRUITING ICI Rechallenge for Advanced NSCLC With Long-Term Response to First-Line ICI
Peking Union Medical College Hospital
NCT04127110 ACTIVE NOT RECRUITING Activity of Lorlatinib Based on ALK Resistance Mutations Detected on Blood in ALK Positive NSCLC Patients
European Organisation for Research and Treatment of Cancer - EORTC
NCT05435248 RECRUITING Phase 1/2 Study of HS-10375 in Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer(NSCLC)
Jiangsu Hansoh Pharmaceutical Co., Ltd.
NCT06667154 RECRUITING Efficacy Analysis of Neoadjuvant Treatment in Lung Cancer Using Low-dose Nivolumab Combined With Chemotherapy
Aline Fusco Fares, MD
NCT05468242 RECRUITING Study of Tislelizumab for Locally Advanced Non-Small Cell Lung Cancer Following Neoadjuvant Chemotherapy Plus Tislelizumab ± Bevacizumab and Definitive Concurrent Chemoradiation Therapy
Sun Yat-sen University
NCT06107374 RECRUITING Imaging Advanced NSCLC Patients Undergoing PD-1/PD-L1 Directed Therapy Using [18F]-FARAG
CellSight Technologies, Inc.
NCT06084806 RECRUITING Test-retest Evaluation of [18F]F-AraG PET
CellSight Technologies, Inc.
NCT04335292 RECRUITING Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge
Mark Vincent
NCT04322890 RECRUITING Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation
Hunan Province Tumor Hospital
NCT06644313 NOT YET RECRUITING Vebreltinib for Neoadjuvant in MET-altered Stage IIIA-IIIB (N2) Non-small Cell Lung Cancer (NSCLC)
Shanghai Pulmonary Hospital, Shanghai, China
NCT05620134 ACTIVE NOT RECRUITING Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
Salubris Biotherapeutics Inc
NCT06634667 NOT YET RECRUITING Third-generation EGFR-TKI Plus Anlotinib as Maintenance for NSCLC With Small Cell Transformation After EGFR-TKI Resistance
Hunan Province Tumor Hospital
NCT04913337 ACTIVE NOT RECRUITING Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
NGM Biopharmaceuticals, Inc
NCT06620822 NOT YET RECRUITING Efficacy of PD-1 Inhibitor Combination Therapy in Non-small Cell Lung Cancer Patients Who Have Not Achieved Major Pathologic Response After Neoadjuvant Immunotherapy: a Multicenter, Phase II Clinical Trial
Shanghai Pulmonary Hospital, Shanghai, China
NCT06249854 RECRUITING Efficacy and Safety of Combination Therapy With Bojungikki-tang and Pembrolizumab Monotherapy in Patients With Advanced Non-small Cell Lung Cancer
Korea Institute of Oriental Medicine
NCT06618391 NOT YET RECRUITING Local Injection and Systemic Therapy in the Treatment of NSCLC.
Henan Cancer Hospital
NCT06614231 NOT YET RECRUITING Neoajuvant Tislelizumab Combined with Chemotherapy for Initially Unresectable Stage IIIA/N2 Non-small Cell Lung Cancer
Sun Yat-sen University
NCT05014464 RECRUITING ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma
Hunan Province Tumor Hospital
NCT06355609 RECRUITING Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR Mutant Advanced NSCLC-RW
Hunan Province Tumor Hospital
NCT06537297 NOT YET RECRUITING Intrathecal Pemetrexed Combined With High-dose Furmonertinib and Beva for EGFR-m NSCLC With Leptomeningeal Metastases
Hunan Province Tumor Hospital
NCT05379803 RECRUITING High-dose Furmonertinib for First-line Treatment of EGFR Mutated NSCLC With Central Nervous System (CNS) Metastases
Hunan Province Tumor Hospital
NCT06604351 NOT YET RECRUITING Bronchoscopic Cryoablation Combined With Chemo-Immunotherapy in NSCLC With Central Airway Obstruction
Hunan Province Tumor Hospital
NCT06348927 RECRUITING Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR-Sensitive Mutations Combined With Co-Mutations Advanced NSCLC
Hunan Province Tumor Hospital
NCT04144569 RECRUITING PD-1 Combined With Pyrotinib for Chemotherapy Failure HER2 Insertion Mutation Advanced NSCLC
Yongchang Zhang
NCT06477055 NOT YET RECRUITING The Recurrence Gene Profiles of Adjuvant Osimertinib Therapy in Resected Non-Small-Cell Lung Cancer
Hunan Province Tumor Hospital
NCT05491811 ACTIVE NOT RECRUITING Ensartinib in Combination With Bevacizumab in ALK-positive NSCLC Patients With TP53 Mutation
Sun Yat-sen University
NCT05295212 RECRUITING Atezolizumab Combined With Platinum-based Chemotherapy as Neoadjuvant Therapy for Patients With Resectable Stage II-IIIB
Hunan Province Tumor Hospital
NCT05766800 RECRUITING Induction Therapy With PD-1 Antibody Combined With Platinum-based Doublet Chemotherapy for Locally-advanced Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT06590194 NOT YET RECRUITING PH009-1 in Patients With EGFR Mutation Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
Suzhou Puhe Pharmaceutical Technology Co., LTD
NCT06501391 RECRUITING Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Stable Brain Metastasis
Fudan University
NCT06501378 RECRUITING Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Active Brain Metastasis
Fudan University
NCT05007938 ACTIVE NOT RECRUITING Befotertinib and Icotinib in Treatment-naive Patients With Advanced EGFR-Mutant Lung Cancer
Betta Pharmaceuticals Co., Ltd.
NCT06224387 RECRUITING CTS2190 Phase I /II Clinical Study in Patients
CytosinLab Therapeutics Co., Ltd.
NCT05229614 RECRUITING Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease
CNAO National Center of Oncological Hadrontherapy
NCT06380816 RECRUITING A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
Cancer Research UK
NCT06554613 NOT YET RECRUITING Olanzapine Impact on First-line Immunotherapy for Advanced EGFR-negative NSCLC
Second Affiliated Hospital of Nanchang University
NCT04685070 ACTIVE NOT RECRUITING Neoadjuvant HS-10296 (Almonertinib) Therapy for Potential Resectable Stage III EGFR Mutation-Positive Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT05015010 ACTIVE NOT RECRUITING Alectinib in Neo-adjuvant Treatment of Stage III NSCLC
Gruppo Oncologico Italiano di Ricerca Clinica
NCT05519865 ACTIVE NOT RECRUITING A Study of Tucidinostat Combined With Tislelizumab as First-line Treatment in Advanced NSCLC
Chipscreen Biosciences, Ltd.
NCT04951583 ACTIVE NOT RECRUITING Fecal Microbial Transplantation Non-Small Cell Lung Cancer and Melanoma
Centre hospitalier de l'Université de Montréal (CHUM)
NCT06534762 RECRUITING Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical Study
Zhejiang Provincial People's Hospital
NCT06528847 RECRUITING Adjuvant Benmelstobart for Stage IB, Grade 3 Invasive Lung Adenocarcinoma
Shanghai Pulmonary Hospital, Shanghai, China
NCT06412471 RECRUITING A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
NCT06525350 NOT YET RECRUITING A Study to Evaluate the Efficacy and Safety of the Combination of Glumetinib and Docetaxel(Albumin Bound)Verse Docetaxel for the Treatment of MET-overexpressed Non-small Cell Lung Cancer
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
NCT06394674 RECRUITING High-dose Furmonertinib in the Treatment in Patients With Advanced, Metastatic NSCLC With Progressed After First- or Second-line Treatment With Osimertinib
Changhai Hospital
NCT06517953 RECRUITING Befotertinib and Icotinib for NSCLC With Uncommon EGFR Mutations
Sun Yat-sen University
NCT06514027 NOT YET RECRUITING Study of BEBT-109 in Subjects With Non-Small Cell Lung Cancer Carrying EGFR Exon 20 Insertion Mutations
BeBetter Med Inc
NCT05013099 ACTIVE NOT RECRUITING Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies
ImaginAb, Inc.
NCT06331455 RECRUITING Treatment of Pulmonary SUlcus, Pancoast and Chest Wall Non-small Cell Lung Cancer Employing Radiation, Immuno-oncology and Resection
Marc de Perrot
NCT04563338 RECRUITING An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)
University Health Network, Toronto
NCT04084717 RECRUITING Study of Crizotinib for ROS1 and MET Activated Lung Cancer
University Health Network, Toronto
NCT06492421 RECRUITING Neoadjuvant Intra-tumor Double Immunotherapy for Lung Cancer.
Second Affiliated Hospital of Guangzhou Medical University
NCT05244213 ACTIVE NOT RECRUITING Neoadjuvant Immunotherapy in EGFR-mutant Localized NSCLC
Guangdong Provincial People's Hospital
NCT06306456 RECRUITING A Phase Ib/II Clinical Study of GH21 Capsules Combined With Osimertinib Mesylate Tablets in Patients With NSCLC
Suzhou Genhouse Bio Co., Ltd.
NCT06480136 NOT YET RECRUITING SHR-A1921 Combined With Adebrelimab in the Treatment of Advanced NSCLC Who Failed the Previous Standard First-line Treatment
Shanghai Pulmonary Hospital, Shanghai, China
NCT06479759 RECRUITING LM-108 Antibody Combination With Sintilimab for Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT06186076 RECRUITING A Study to Investigate Safety, Tolerability, PK and Anti-tumor Activity of TRX-221 in EGFRm NSCLC Patients
Therapex Co., Ltd
NCT06475755 NOT YET RECRUITING Neoadjuvant/Adjuvant Tislelizumab Combined With Anlotinib and Platinum Doublet Chemotherapy With Resectable NSCLC
Tang-Du Hospital
NCT05269485 RECRUITING Hypofraction Radiotherapy for Locally Advanced Non-small Cell Lung Cancer
Anhui Provincial Hospital
NCT05532696 RECRUITING Phase 1b/2 Study to Evaluate ABT-101 in Solid Tumor and NSCLC Patients
Anbogen Therapeutics, Inc.
NCT06467500 RECRUITING A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy
Xin-Hua Xu
NCT06465238 NOT YET RECRUITING Clinical Study of SHR-A1921 or SHR-A2009 in Previously Treated Advanced NSCLC
Henan Cancer Hospital
NCT05816499 ACTIVE NOT RECRUITING Cadonilimab in Patients (Pts) With Advanced Non-small Cell Lung Cancer (NSCLC)
Shanghai Chest Hospital
NCT05933239 RECRUITING Macrophage Imaging Using Ga-MMR-VHH2 in Lung Cancer Patients
Universitair Ziekenhuis Brussel
NCT04818333 ACTIVE NOT RECRUITING A Study of SHR-A1811 in Subjects With Advanced Non-small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
NCT06454890 NOT YET RECRUITING Clinical Study of Trop2 CAR-NK in the Treatment of Relapsed/Refractory Non-Small Cell Lung Cancer (NSCLC)
Henan Cancer Hospital
NCT06452433 NOT YET RECRUITING Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05284539 RECRUITING Efficacy of Platinum-based Chemotherapy Plus Immune Checkpoint Inhibitors for EGFR/ALK/ROS1 Mutant Lung Cancer
Hunan Province Tumor Hospital
NCT06445881 RECRUITING Efficacy and Safety of Modified Si Jun Zi Tang in Perioperative NSCLC Treatment
First Affiliated Hospital of Zhejiang University
NCT06313541 RECRUITING Treatment Response Adapted Hybrid Radiotherapy in Metastatic Non-small Cell Lung Cancer Receiving First-line Immunotherapy
Fudan University
NCT06440954 RECRUITING Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases
Hunan Province Tumor Hospital
NCT04322578 RECRUITING Crizotinb or Standard Chemotherapy in Met Exon 14 Skipping Advanced NSCLC
Hunan Province Tumor Hospital
NCT06045767 NOT YET RECRUITING T-Cell Repertoire Sequencing: Assessing Pembrolizumab Efficacy in Advanced Non-small Lung Cancer
Ari Raphael
NCT06434103 NOT YET RECRUITING Clinical Study of SHR-A1921 Combined With Adebrelimab and SHR-8068 With or Without Carboplatin in the Treatment of Advanced NSCLC
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT06436144 NOT YET RECRUITING Osimertinib and Etoposide as First-Line Treatment in Osimertinib-Resistant Advanced EGFR-Mutant NSCLC
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT06109558 RECRUITING The Efficacy and Safety of LMV-12 Combined With Osimertinib in NSCLC
Hunan Province Tumor Hospital
NCT05584267 RECRUITING Immune Treatment of Brain Metastasis of Lung Cancer Combined With Large-segmentation Precision Radiotherapy
Hunan Province Tumor Hospital
NCT05878028 RECRUITING L-TIL Plus Tislelizumab for PD1 Antibody Resistant aNSCLC
Quanli Gao
NCT06424821 RECRUITING Cadonilimab Plus Chemotherapy as First-line Treatment for PD-L1 Negative NSCLC
Shanghai Pulmonary Hospital, Shanghai, China
NCT06424899 RECRUITING A Study Comparing Neoadjuvant Chemoimmunotherapy and Immuno-consolidationafter Compared With Immunoconsolidation After Radical Chemoradiotherapy for Stage III Potentially Resectable NSCLC
Zeng Jian
NCT05955105 RECRUITING A Study of ILB2109 and Toripalimab in Patients With Advanced Solid Malignancies
Innolake Biopharm
NCT06361927 RECRUITING A Phase II Study of SSGJ-707 Monotherapy in First-line PD-L1 Positive Advanced NSCLC Patients
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
NCT06414915 NOT YET RECRUITING Surufatinib Combined With Tislelizumab in Advanced Lung Cancer With Neuroendocrine Differentiation
National Cancer Center, China
NCT04865250 RECRUITING Predicting Response to Neoadjuvant ATEZOLIZUMAB Plus Carboplatin/Nab Paclitaxel in Resectable Non-squamous NSCLC
University Hospital Heidelberg
NCT04205552 RECRUITING Neoadjuvant Nivolumab Combination Treatment in Resectable Non-small Cell Lung Cancer Patients
University Hospital, Essen
NCT05859217 NOT YET RECRUITING A Study of Combining Cabozantinib and Atezolizumab for Advanced/Metastatic NSCLC (Cabatezo-1)
Jun Zhang, MD, PhD
NCT03833440 ACTIVE NOT RECRUITING Precision Immuno-Oncology for Advanced Non-small Cell Lung Cancer Patients With PD-1 ICI Resistance
Assistance Publique Hopitaux De Marseille
NCT05420220 RECRUITING Study of KN046 in Subjects With Advanced Non-Small Cell Lung Cancer
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
NCT05805631 NOT YET RECRUITING Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC
Taipei Veterans General Hospital, Taiwan
NCT04622007 ACTIVE NOT RECRUITING Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)
Effector Therapeutics
NCT06391944 ACTIVE NOT RECRUITING JMT101 Combined With Osimertinib in Patients With Stage Ⅲb-Ⅳ Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Common Mutations
Shanghai JMT-Bio Inc.
NCT06391008 NOT YET RECRUITING Immunosensitized Radiotherapy Combined With Evoximab (AK112) and Chemotherapy Neoadjuvant Therapy for Stage II-III Non-small Cell Lung Cancer
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
NCT06378892 RECRUITING A Study to Evaluate the Combination of Platinum-pemetrexed Based Chemotherapy Plus Lorlatinib in ALK Positive Non-Small Cell Lung Cancer (NSCLC) With Exclusively Extracranial Disease Progression on Lorlatinib
Centro di Riferimento Oncologico - Aviano
NCT05383716 ACTIVE NOT RECRUITING Neoadjuvant/Adjuvant Pembrolizumab Plus Chemotherapy
Peking Union Medical College Hospital
NCT06300424 RECRUITING Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC
Guangdong Provincial People's Hospital
NCT04147351 ACTIVE NOT RECRUITING A Phase II Study of Atezolizumab in Combination With Bevacizumab, Carboplatin or Cisplatin, and Pemetrexed for EGFR-mutant Metastatic Non-small Cell Lung Cancer Patients After Failure of EGFR Tyrosine Kinase Inhibitors.
National Taiwan University Hospital
NCT06363734 RECRUITING Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial
Tianjin Medical University Cancer Institute and Hospital
NCT05240131 ACTIVE NOT RECRUITING A Study to Investigate the Safety and Efficacy of GB1211 (a Galectin-3 Inhibitor) in Combination With Atezolizumab in Patients With Non-Small Cell Lung Cancer (NSCLC).
Galecto Biotech AB
NCT05519293 RECRUITING Phase I/IIa Study of H002 in NSCLC With Active EGFR Mutation
RedCloud Bio
NCT05552781 RECRUITING H002 in Patients With EGFR Mutation Locally Advanced or Metastatic NSCLC
RedCloud Bio
NCT05821933 RECRUITING RC108 Combine With Furmonertinib With/Without Toripalimab in Patients With EGFR-mutated NSCLC
RemeGen Co., Ltd.
NCT06341660 RECRUITING To Evaluate the Safety and Tolerability of Carbognilumab Combined With Chemotherapy as the First-line Treatment for Patients With KEAP1 Mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer (NSCLC)
Guangzhou Institute of Respiratory Disease
NCT06341530 RECRUITING Anlotinib Combined With Penpulimab as Front-line Treatment in Advanced Non-small Cell Lung Cancer
The First Affiliated Hospital of Zhengzhou University
NCT06339242 RECRUITING A Study of Furmonertinib Combined With Chemotherapy in the Treatment of NSCLC With Leptomeningeal Metastasis
Jiangsu Province Nanjing Brain Hospital
NCT06336954 NOT YET RECRUITING Adibelimab, Famitinib and Chemotherapy for Advanced NSCLC After PD-1 Inhibitor Failure
Second Affiliated Hospital of Xi'an Jiaotong University
NCT06332287 RECRUITING A Study of Trilaciclib Combined With Chemotherapy in the Treatment of Advanced NSCLC With Leptomeningeal Metastasis
Jiangsu Province Nanjing Brain Hospital
NCT06331650 RECRUITING A Single-arm Pilot Study of First-line Treatment With Carbognilumab Combined With Chemotherapy in Patients With STK11-mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer
Guangzhou Institute of Respiratory Disease
NCT06328049 RECRUITING A Study of Trilaciclib Combined With Chemotherapy in the Treatment of NSCLC
Taixing People's Hospital
NCT06195189 RECRUITING Sunvozertinib Combined With Chemotherapy for EGFRm After EGFR-TKI Treatment Failure:Phase I/II
Sichuan University
NCT06315686 RECRUITING The Dynamic Monitoring of Cerebrospinal Fluid ctDNA
Jiangsu Province Nanjing Brain Hospital
NCT04903873 RECRUITING A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors
Eutilex
NCT05004974 RECRUITING Sintilimab With Pemigatinib in Patients With PD-L1-positive and FGFR Mutated Advanced Non-small Cell Lung Cancer
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
NCT06277674 RECRUITING Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI
Guangzhou University of Traditional Chinese Medicine
NCT06297811 NOT YET RECRUITING Myeloprotection With Trilaciclib in Pan-cancer Population
Sun Yat-sen University
NCT06299371 NOT YET RECRUITING Adebrelimab Plus Chemotherapy as Neoadjuvant Therapy in Resectable NSCLC Harboring Driver Gene Mutations
Liaoning Cancer Hospital & Institute
NCT04984811 ACTIVE NOT RECRUITING NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC
NeoImmuneTech
NCT04392505 ACTIVE NOT RECRUITING Durvalumab(MEDI4736) After chemoRadioTherapy(DART) for NSCLC-a Translational and Biomarker Study
Oslo University Hospital
NCT06282536 NOT YET RECRUITING Neoadjuvant Therapy With Iruplinalkib for Potentially Resectable ALK Positive NSCLC: A Single Arm, Exploratory Trial
Shanghai Pulmonary Hospital, Shanghai, China
NCT06022757 RECRUITING Study of XNW5004 Tablet in Combination With KEYTRUDA® (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)
Evopoint Biosciences Inc.
NCT05377658 RECRUITING AK104 With Chemotherapy as Neoadjuvant and Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
Henan Cancer Hospital
NCT05163249 ACTIVE NOT RECRUITING Osimertinib With or Without Savolitinib as 1L in de Novo MET+, EGFR+ NSCLC
Guangdong Association of Clinical Trials
NCT04326153 ACTIVE NOT RECRUITING Neoadjuvant Immunotherapy Plus Chemotherapy for Potentially Resectable Stage IIIA/IIIB Non-Small Cell Lung Cancer
The First Hospital of Jilin University
NCT06221462 NOT YET RECRUITING Neoadjuvant Sintilimab Plus Anlotinib Therapy in IB-IIIB Resectable Non-small Cell Lung Cancer
Ningbo No.2 Hospital
NCT05011487 RECRUITING Neoadjuvant Osimertinib + Chemotherapy for EGFR-mutant Stage III NSCLC
Sun Yat-sen University
NCT05296278 RECRUITING Efficacy and Biomarker Explanation of IBI-323 + Bevacizumab Plus Platinum Based Chemotherapy on ALK-Rearranged NSCLC
Hunan Province Tumor Hospital
NCT06192849 RECRUITING To Assess the Efficacy and Safety of Furmonertinib in Patients With Epidermal Growth Factor Receptor 20ins Mutation Positive Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy
Juan LI, MD
NCT06185400 NOT YET RECRUITING RC48 Combined With EGFR or HER2 TKI for Locally Advanced or Metastatic NSCLC Patients With HER2 Alterations
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06182761 NOT YET RECRUITING A Study of Sunvozertinib Combined With Anlotinib in Local Advanced or Metastatic Non-small Cell Lung Cancer
Shanghai Zhongshan Hospital
NCT06109402 NOT YET RECRUITING Perioperative Immunotherpay Versus Adjuvant Immunotherapy for Resectable Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT05351788 RECRUITING SKB264 Combinatiton Therapy in Patients With Advanced or Metastatic Non-small Cell Lung Cancer.
Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.
NCT04992780 RECRUITING Comparing Hypo-fractionated Intensity- Modulated Radiation Therapy to Standard- Fractionated IMRT Along With Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer
University of Kansas Medical Center
NCT04379739 ACTIVE NOT RECRUITING Neoadjuvant PD-1 Antibody Plus Apatinib or Chemotherapy for Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT06143735 NOT YET RECRUITING A Study of Efbemalenograstim Alfa Injection for Stage IIIB or IV NSCLC Recieving Moderate-risk Febrile Neutropenia (FN) Chemotherapy Regimen With Risk Factors
Tianjin Medical University Cancer Institute and Hospital
NCT06142617 NOT YET RECRUITING A Prospective Study of Pembrolizumab Combining Chemotherapy in Advanced NSCLC Patients With EGFR Exon 21 Point Mutation.
Peking Union Medical College Hospital
NCT03319628 ACTIVE NOT RECRUITING First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b
Mersana Therapeutics
NCT05344209 RECRUITING Efficacy and Safety of Anti-PD-1/PD-L1 Treatment +/- UV1 Vaccination in Patients With Non-small Cell Lung Cancer
Vestre Viken Hospital Trust
NCT06092086 RECRUITING Lorlatinib as the First-line Treatment in China Advanced ALK+ NSCLC
Guangdong Association of Clinical Trials
NCT05777278 RECRUITING Savolitinib Plus Docetaxel as 2L in EGFR/ALK/ROS1/MET ex14m-wildtype NSCLC With MET Overexpression
The First Affiliated Hospital of Guangzhou Medical University
NCT05241028 RECRUITING Adjuvant Therapy of Ensartinib in Stage IB-IIIA ALK-positive Non-small Cell Lung Cancer
Hebei Medical University Fourth Hospital
NCT06054191 NOT YET RECRUITING Neoadjuvant and Adjuvant Targeted Treatment in NSCLC With BRAF V600 or MET Exon 14 Mutations
Sun Yat-sen University
NCT06065813 RECRUITING Neoadjuvant Triprizumab and Radiotherapy in Operable Patients With Stage IIA-IIIA Non-small Cell Lung Cancer
Northern Jiangsu People's Hospital
NCT06018688 NOT YET RECRUITING Osimertinib Combined With Aspirin Neoadjuvant Therapy for Resectable EGFR Mutated NSCLC Patients.
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT04728724 RECRUITING Neoadjuvant Immunotherapy for Stage III Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT06028633 NOT YET RECRUITING Efficacy and Safety of Nab-paclitaxel-Lenvatinib-Pembrolizumab as Second-line Treatment in Advanced NSCLC Patients
Peking University First Hospital
NCT05841472 RECRUITING Anti-PD-1 Antibody Therapies of Camrelizumab in Combination With Pemetrexed and Carboplatin as First-line Treatment in Patients With Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
CrystalGenomics, Inc.
NCT05892237 RECRUITING CIETAI and Sequential Radiotherapy in Squamous Lung Cancer
Dong Wang
NCT06001151 RECRUITING Cadonilimab (AK104) Plus Chemotherapy as First-line Treatment in Non-squamous Non-Small Cell Lung Cancer (NSCLC) Patients With Programmed Cell Death Ligand 1 (PD-L1) Negative
Qian Chu
NCT05978401 NOT YET RECRUITING Safety, Tolerability, and Efficacy of GLS-012 and GLS-010 in Patients With Advanced Non-Small Cell Lung Cancer
Guangzhou Gloria Biosciences Co., Ltd.
NCT05962021 NOT YET RECRUITING Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation
Peking University People's Hospital
NCT05751187 RECRUITING Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients
Shanghai Chest Hospital
NCT05940532 RECRUITING A Trial of Sugemalimab and Chemotherapy in Unresectable Stage III NSCLC
Hunan Cancer Hospital
NCT05913089 RECRUITING A Clinical Study of TQB2450 Injection Combined With Chemotherapy or Anlotinib Hydrochloride Capsule in the Treatment of Non Small Cell Lung Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
NCT05910034 NOT YET RECRUITING Envafolimab Plus Docetaxel In Combination With or Without Trilaciclib Versus Docetaxel in Advanced NSCLC
Fudan University
NCT05891080 NOT YET RECRUITING Neoadjuvant Therapy With Toripalimab and JS004 Combined With Platinum-based Doublet Chemotherapy for Resectable or Potentially Resectable Stage III Non-small Cell Lung Cancer: A Randomised Controlled, Open-label, Phase 2 Trial
Shanghai Pulmonary Hospital, Shanghai, China
NCT05865730 RECRUITING A Study of Oncobax®-AK in Patients With Advanced Solid Tumors
EverImmune
NCT05271916 RECRUITING First-line Treatment With Dacomitinib Plus Anlotinib for Patients With Advanced NSCLC With EGFR 21L858R Mutations
Shanghai Chest Hospital
NCT05800340 RECRUITING Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC
Guangdong Provincial People's Hospital
NCT05778149 NOT YET RECRUITING Safety and Efficacy of Aumolertinib Combined With Anlotinib as 1st Line Treatment in Advanced Lung Cancer EGFR Mutation With TP53 Co-Mutation
Tianjin Medical University Cancer Institute and Hospital
NCT05286957 RECRUITING MRD-guided Adjuvant Tislelizumab and Chemotherapy in Resected Stage IIA-IIIB NSCLC
The First Affiliated Hospital of Zhengzhou University
NCT05445310 RECRUITING Adjuvant Furmonertinib in Stage IA With High Risk Factors and Stage IB Non-small Cell Lung Cancer
Peking Union Medical College Hospital
NCT05686434 RECRUITING Osimertinib Therapy After Resection in High-risk Stage I EGFRm NSCLC (OSTAR)
Tianjin Medical University Cancer Institute and Hospital
NCT05597800 NOT YET RECRUITING Nivolumab/Ipilimumab and Chemotherapy Combination in Advanced NSCLC Patients With HIV, HBV, HCV and Long Covid Syndrome
Universita di Verona
NCT05548504 NOT YET RECRUITING Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC
Odense University Hospital
NCT05334277 RECRUITING Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA
Sun Yat-sen University
NCT04996121 RECRUITING A Study of XZP-5955 Tablets in Patients With NTRK or ROS1 Fusion Positive Locally Advanced or Metastatic Solid Tumors
Xuanzhu Biopharmaceutical Co., Ltd.
NCT04875585 RECRUITING Trial Exploring Combined Neoadjuvant Therapy With Pembrolizumab/Lenvatinib + Adjuvant Pembrolizumab in Pat. With NSCLC
Medical University Innsbruck
NCT05416775 RECRUITING Phase Ib/II Study of SHR-8068 Injection in the Treatment of Advanced Non-small Cell Lung Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT05503888 NOT YET RECRUITING Phase Ib/II Study of Almonertinib Combined With SHR-1701 in the Treatment of Relapsed or Advanced Non-small Cell Lung Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT05469022 RECRUITING Neoadjuvant Lazertinib Therapy in EGFR-Mutation Positive Lung Adenocarcinoma Detected by BALF Liquid Biopsy
Konkuk University Medical Center
NCT05351320 RECRUITING WX-0593 Combined With Concurrent Chemoradiotherapy in Unresectable Locally Advanced NSCLC
Jinming Yu
NCT05306847 NOT YET RECRUITING Sintilimab Combined With Anlotinib Therapy for Initially Unresectable Non-small Cell Lung Cancer
Peking Union Medical College Hospital
NCT03836352 ACTIVE NOT RECRUITING Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
ImmunoVaccine Technologies, Inc. (IMV Inc.)
NCT05186506 NOT YET RECRUITING A Study Comparing Ensatinib Versus Platinum-Based Chemotherapy as Adjuvant Treatment for Stage II-IIIA ALK -Positive Non-Small Cell Lung Cancer
Sichuan University
NCT05132985 NOT YET RECRUITING Neoadjuvant Icotinib With Chemotherapy for Epidermal Growth Factor Receptor(EGFR)-Mutated Resectable Lung Adenocarcinoma
Liaoning Cancer Hospital & Institute
NCT05104788 RECRUITING A Study of Icotinib With Chemotherapy as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
Peking University Cancer Hospital & Institute
NCT04304248 ACTIVE NOT RECRUITING Neoadjuvant Toripalimab Plus Platinum-based Doublet for Stage III Non-small Cell Lung Cancer
Hao Long
NCT04846634 NOT YET RECRUITING Penpulimab-based Combination Neoadjuvant/Adjuvant Therapy for Patients With Resectable Locally Advanced Non-small Cell Lung Cancer: a Phase II Clinical Study (ALTER-L043)
Tianjin Medical University Cancer Institute and Hospital
NCT04153734 NOT YET RECRUITING Pembrolizumab + Platinum Doublets Without Radiation for Programmed Death-ligand 1 (PD-L1) ≥50% Locally Advanced NSCLC
Kobe Minimally Invasive Cancer Center
NCT03694236 RECRUITING Concurrent Neoadjuvant Chemoradiotherapy Plus Durvalumab (MEDI4736) in Resectable Stage III NSCLC
Yonsei University
NCT03392233 RECRUITING Stereotactic Body Radiation Therapy for Spinal Metastases in Favorite Tumors
RenJi Hospital
NCT04880382 TERMINATED Integrative Analysis of Tumor Microenvironment and Optimization of Immunotherapy Duration in NSCL Cancer Patients
Institut Bergonié
NCT05642195 SUSPENDED Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer
National Cancer Institute (NCI)
NCT03083041 COMPLETED A Study of SHR-1210 in Combination With Apatinib in Advanced Non-Small Cell Lung Cancer(NSCLC)
Jiangsu HengRui Medicine Co., Ltd.
NCT04900363 COMPLETED A Trial of AK112 (PD-1/VEGF Bispecific Antibody) in Patients With NSCLC
Akeso
NCT06171789 TERMINATED PRO1107 in Patients With Advanced Solid Tumors
Genmab
NCT05263947 COMPLETED Bevacizumab Combined With Double Doses of Icotinib in Advanced NSCLC Patients With EGFR L858R Mutation
Tianjin Medical University Cancer Institute and Hospital
NCT05566223 WITHDRAWN CISH Inactivated TILs in the Treatment of NSCLC
Intima Bioscience, Inc.
NCT03066206 TERMINATED Poziotinib in EGFR Exon 20 Mutant Advanced NSCLC
M.D. Anderson Cancer Center
NCT03366766 TERMINATED Nivolumab Plus Cisplatin/Pemetrexed or Cisplatin/Gemcitabine as Induction in Resectable Non-Small Cell Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT02523469 COMPLETED ALT-803 Plus Nivolumab in Patients With Pretreated, Advanced or Metastatic Non-Small Cell Lung Cancer
Medical University of South Carolina
NCT03559049 TERMINATED Rucaparib and Pembrolizumab for Maintenance Therapy in Stage IV Non-Squamous Non-Small Cell Lung Cancer
University of Michigan Rogel Cancer Center
NCT05577702 COMPLETED Efficacy, Safety, and Pharmacodynamics of Tislelizumab Monotherapy and Multiple Tislelizumab-based Immunotherapy Combinations in Participants With Resectable Non-Small Cell Lung Cancer
BeiGene
NCT05551117 TERMINATED A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors
MacroGenics
NCT04332653 COMPLETED NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
NeoImmuneTech
NCT03133546 COMPLETED Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M
ETOP IBCSG Partners Foundation
NCT06682806 TERMINATED A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation
Prelude Therapeutics
NCT05429320 COMPLETED A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)
Memorial Sloan Kettering Cancer Center
NCT06333678 COMPLETED A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)
Memorial Sloan Kettering Cancer Center
NCT05746481 TERMINATED Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases
Liza Villaruz, MD
NCT05070247 TERMINATED A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tumors
Takeda
NCT03003468 COMPLETED Pembrolizumab + Imprime PGG for Metastatic Non-small Cell Lung Cancer After Progression on First-Line Therapy: Big Ten Cancer Research Consortium BTCRC-LUN15-017
Lawrence Feldman, MD
NCT03285321 COMPLETED Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC)
Greg Durm, MD
NCT03563716 COMPLETED A Study of Tiragolumab in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Genentech, Inc.
NCT04452877 COMPLETED A Study of Dabrafenib in Combination With Trametinib in Chinese Patients With BRAF V600E Mutant Metastatic NSCLC
Novartis Pharmaceuticals
NCT05002270 COMPLETED JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation
Jacobio Pharmaceuticals Co., Ltd.
NCT04260802 TERMINATED A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
Ocellaris Pharma, Inc.
NCT02442349 COMPLETED Phase II Single Arm Study of AZD9291 to Treat NSCLC Patients in Asia Pacific
AstraZeneca
NCT04563871 COMPLETED Efficacy and Safety of 80mg Osimertinib in Patients With Non-small Cell Lung Cancer(NSCLC)
Samsung Medical Center
NCT04585815 TERMINATED Study of Immunotherapy (Sasanlimab) in Combination With Targeted Therapies in People With Advanced Non-small Cell Lung Cancer (NSCLC) (Landscape 1011 Study)
Pfizer
NCT04966676 TERMINATED Study of Nivolumab-Ipilimumab and cfDNA in Lung Cancer
University Health Network, Toronto
NCT03425331 TERMINATED Biomarkers of Response to Ipilimumab and Nivolumab in First-line NSCLC
Dana-Farber Cancer Institute
NCT05348668 COMPLETED Hybrid Dose-fraction Radiotherapy for Metastatic Non-small Cell Lung Cancer
Anhui Provincial Hospital
NCT05054725 COMPLETED Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies
Revolution Medicines, Inc.
NCT06029127 COMPLETED A Study of Gimistotug (BGB-A445) in Combination With Other Investigational Agents in Participants With Non-Small Cell Lung Cancer
BeiGene
NCT02473133 COMPLETED Study of Interest of Personalized Radiotherapy Dose Redistribution in Patients With Stage III NSCLC
Centre Henri Becquerel
NCT04224337 COMPLETED Phase II Study of Durvalumab ,Doxorubicin, and Ifosfamide in Pulmonary Sarcomatoid Carcinoma
Seoul National University Hospital
NCT05141357 TERMINATED A Study of HBI-8000 (Tucidinostat) With Pembrolizumab in Non-Small Cell Lung Cancer
HUYABIO International, LLC.
NCT05465343 COMPLETED Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)
Peking Union Medical College
NCT04965090 COMPLETED A Study of Amivantamab and Lazertinib in People With Non-Small Cell Lung Cancer (NSCLC)
Memorial Sloan Kettering Cancer Center
NCT05313009 TERMINATED Tarlox and Sotorasib in Patients With KRAS G12C Mutations
Medical University of South Carolina
NCT04765709 TERMINATED Durvalumab and Chemotherapy Induction Followed by Durvalumab and Radiotherapy in Large Volume Stage III NSCLC
Mario Negri Institute for Pharmacological Research
NCT05001347 COMPLETED A Clinical Study of TJ004309 With Atezolizumab (TECENTRIQ®) in Patients With Ovarian Cancer and Selected Solid Tumors
I-Mab Biopharma US Limited
NCT03337698 COMPLETED A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)
Hoffmann-La Roche
NCT05171777 COMPLETED A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer
Hoffmann-La Roche
NCT04916002 TERMINATED A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer
Regeneron Pharmaceuticals
NCT06219174 SUSPENDED Targeting ODC as an Immunotherapeutic Target in STK11 (LKB1) Pathway-Deficient NSCLC (DFMO)
H. Lee Moffitt Cancer Center and Research Institute
NCT04844073 TERMINATED A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer
Takeda
NCT03836066 COMPLETED Atezolizumab Plus Bevacizumab in First Line NSCLC Patients
Fundación GECP
NCT05440916 COMPLETED Palliative RadIotherapy of Multiple Metastatic Sites Before First Line of Systemic Therapy With Immune Checkpoint Inhibitors and Chemotherapy in Metastatic Non-Small-Cell Lung Cancer
University Medical Centre Maribor
NCT04165083 COMPLETED KEYMAKER-U01 Substudy 2: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Treatment-naïve Participants With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Positive Advanced Non-small Cell Lung Cancer (NSCLC) (MK-3475-01B/KEYMAKER-U01B)
Merck Sharp & Dohme LLC
NCT04644237 COMPLETED Trastuzumab Deruxtecan in Participants With HER2-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)
Daiichi Sankyo
NCT04725331 TERMINATED A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors
Transgene
NCT04549428 TERMINATED Atezolizumab Plus 8 Gy Single-fraction Radiotherapy for Advanced Oligoprogressive NSCLC
Oncology Institute of Southern Switzerland
NCT05383482 COMPLETED Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1
Laekna Limited
NCT05256381 TERMINATED A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors
SOTIO Biotech AG
NCT03915951 COMPLETED An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
Pfizer
NCT03916419 COMPLETED Magnetic Resonance-Guided Hypofractionated Adaptive Radiation Therapy With Concurrent Chemotherapy and Consolidation Durvalumab for Inoperable Stage IIB, IIIA, and Select IIIB and IIIC Non-small Cell Lung Cancer
Washington University School of Medicine
NCT05194735 TERMINATED Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors
Alaunos Therapeutics
NCT02823990 COMPLETED TG4010 and Nivolumab in Patients With Lung Cancer
Megan Daly, MD
NCT04504916 TERMINATED A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)
VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT02316002 COMPLETED Phase II Study of Pembrolizumab After Curative Intent Treatment for Oligometastatic Non-Small Cell Lung Cancer
Abramson Cancer Center at Penn Medicine
NCT03909971 COMPLETED A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in China
Pfizer
NCT05469178 TERMINATED A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene
BerGenBio ASA
NCT02572843 COMPLETED Anti-PD-L1 in Stage IIIA(N2) Non-small Cell Lung Cancer (NSCLC)
Swiss Cancer Institute
NCT05513703 TERMINATED A Study to Assess Disease Activity of Intravenously (IV) Infused Telisotuzumab Vedotin in Adult Participants With Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
AbbVie
NCT03049618 COMPLETED Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475
University of Southern California
NCT04933695 COMPLETED A Study of Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment
Amgen
NCT04926831 TERMINATED Phase II of Neoadjuvant and Adjuvant Capmatinib in NSCLC
Novartis Pharmaceuticals
NCT03573947 COMPLETED Phase II Clinical Trial of NIVO-IPI-TAXANE in Untreated Metastatic NSCLC
Jeffrey Clarke
NCT03237377 TERMINATED Neoadjuvant Immunoradiation for Resectable Non-Small Cell Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04108026 COMPLETED Immunotherapy in Patient With Poor General Condition
Intergroupe Francophone de Cancerologie Thoracique
NCT04914897 TERMINATED A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma (Pegathor Lung 202)
Sanofi
NCT04985604 TERMINATED Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors
Day One Biopharmaceuticals, Inc.
NCT05386888 COMPLETED A Trial of GFH018 and Toripalimab in Combination With Concurrent Chemoradiotherapy in Stage III NSCLC Chemoradiotherapy in Stage III NSCLC
Genfleet Therapeutics (Shanghai) Inc.
NCT05775796 COMPLETED Evaluate the Efficacy and Safety of Serplulimab Plus Chemotherapy in Neoadjuvant and Adjuvant Treatment of Resectable NSCLC (ECTOP-1013)
Fudan University
NCT03184571 COMPLETED Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
BerGenBio ASA
NCT05588609 TERMINATED Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers
Merus B.V.
NCT05472623 WITHDRAWN Neoadjuvant KRAS G12C Directed Therapy With Adagrasib (MRTX849) With or Without Nivolumab
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05662670 TERMINATED A Phase I/II Study of WJ13404 Monotherapy in Patients With Advanced or Mentastatic Non-Small Cell Lung Cancer
Suzhou Junjing BioSciences Co., Ltd.
NCT05577715 TERMINATED A Study of MORAb-202 in Participants With Previously Treated Metastatic Non-Small Cell Lung Cancer (NSCLC) Adenocarcinoma (AC)
Bristol-Myers Squibb
NCT06084689 WITHDRAWN Targeting MDMD and PD1 in Tumors With Tertiary Lymphoid Structures
Institut Bergonié
NCT05245071 TERMINATED Tusamitamab Ravtansine in NSQ NSCLC Participants With Negative or Moderate CEACAM5 Expression Tumors and High Circulating CEA
Sanofi
NCT03977467 COMPLETED Atezolizumab and Tiragolumab in Patients With NSCLC or Advanced Solid Tumors Having Had Prior Treatment With a PD-1 Inhibitor
SCRI Development Innovations, LLC
NCT04262856 COMPLETED Study to Evaluate Monotherapy and Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer
Arcus Biosciences, Inc.
NCT05259696 COMPLETED Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)
Palleon Pharmaceuticals, Inc.
NCT04646330 COMPLETED A Trial of AK104 Plus Anlotinib in NSCLC
Akeso
NCT04725188 COMPLETED Pembrolizumab/Vibostolimab Coformulation (MK-7684A) or Pembrolizumab/Vibostolimab Coformulation Plus Docetaxel Versus Docetaxel for Metastatic Non Small Cell Lung Cancer (NSCLC) With Progressive Disease After Platinum Doublet Chemotherapy and Immunotherapy (MK-7684A-002, KEYVIBE-002)
Merck Sharp & Dohme LLC
NCT05756153 COMPLETED A Study of GFH925 in Combination With Cetuximab in Previously Untreated Advanced NSCLC Harboring KRAS G12C Mutation
Genfleet Therapeutics (Shanghai) Inc.
NCT06676917 WITHDRAWN Datopotamab Deruxtecan (Dato-DXd) for Non-Small Cell Lung Cancer (NSCLC) Patients With Active Brain Metastases
MedSIR
NCT03568656 COMPLETED Study to Evaluate CCS1477 in Advanced Tumours
CellCentric Ltd.
NCT02546986 COMPLETED Safety and Efficacy Study of CC-486 With MK-3475 to Treat Locally Advanced or Metastatic Non-small Cell Lung Cancer
Celgene
NCT02681549 COMPLETED Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)
Yale University
NCT05253807 COMPLETED Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration
Incyte Corporation
NCT03383302 COMPLETED SBRT With Immunotherapy in Early Stage Non-small Cell Lung Cancer: Tolerability and Lung Effects
Royal Marsden NHS Foundation Trust
NCT03535740 COMPLETED A Study of Brigatinib in Participants With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced Non-Small-Cell Lung Cancer (NSCLC) Progressed on Alectinib or Ceritinib
Ariad Pharmaceuticals
NCT03729596 TERMINATED MGC018 With or Without MGA012 in Advanced Solid Tumors
MacroGenics
NCT05617313 TERMINATED Study of GT103 in Combination With Pembrolizumab in Refractory, Metastatic Non-Small Cell Lung Cancer
Jeffrey Clarke
NCT05691829 TERMINATED Immunotherapy With Non-Ablative Radiation in Previously Untreated Patients With Stage IV NSCLC
NYU Langone Health
NCT05714553 TERMINATED NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
NuCana plc
NCT03087708 TERMINATED Naloxegol in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer
Alliance for Clinical Trials in Oncology
NCT05879484 WITHDRAWN Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: The PANTHERAS
National Cancer Institute (NCI)
NCT05563272 TERMINATED 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
Telix Pharmaceuticals (Innovations) Pty Ltd
NCT03777124 TERMINATED Phase II Study of SHR-1210(Anti-PD-1 Antibody) Combination With Apatinib Versus Pemetrexed and Carboplatin in Subjects With KRAS Mutant Stage IV Non-squamous Non-small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
NCT05765734 TERMINATED A Study of TAS3351 in NSCLC Patients With EGFRmt
Taiho Oncology, Inc.
NCT03516981 COMPLETED A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)
Merck Sharp & Dohme LLC
NCT04165096 COMPLETED KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)
Merck Sharp & Dohme LLC
NCT02299141 COMPLETED Nintedanib in Molecularly Selected Patients With Advanced Non-Small Cell Lung Cancer
Washington University School of Medicine
NCT04677595 COMPLETED Study of Capmatinib in Chinese Adult Patients With Advanced Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation
Novartis Pharmaceuticals
NCT02705820 COMPLETED Switch Maintenance Pembrolizumab in Patients With NSCLC After First Line Platinum Doublet Chemotherapy
Bank of Cyprus Oncology Centre
NCT04908111 SUSPENDED A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1
Cancer Research UK
NCT02262325 COMPLETED Hypofractionated Boost Before Chemoradiation for Patients With Stage II-III Non-small Cell Lung Cancer Unsuitable for Surgery
Ohio State University Comprehensive Cancer Center
NCT03094169 TERMINATED AVID100 in Advanced Epithelial Carcinomas
Formation Biologics
NCT04394624 TERMINATED Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Pretreated Patients With NSQ NSCLC (CARMEN-LC04)
Sanofi
NCT04820023 TERMINATED Phase 1/2 Study of BBT-176 in Advanced NSCLC With Progression After EGFR TKI Treatment
Bridge Biotherapeutics, Inc.
NCT03037385 COMPLETED Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
Hoffmann-La Roche
NCT05546476 COMPLETED Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
Pfizer
NCT04042558 COMPLETED A Study Evaluating Platinum-Pemetrexed-Atezolizumab (+/-Bevacizumab) for Patients With Stage IIIB/IV Non-squamous Non-small Cell Lung Cancer With EGFR Mutations, ALK Rearrangement or ROS1 Fusion Progressing After Targeted Therapies
Centre Francois Baclesse
NCT03505710 TERMINATED DS-8201a in Human Epidermal Growth Factor Receptor 2 (HER2)-Expressing or -Mutated Non-Small Cell Lung Cancer
Daiichi Sankyo
NCT03242915 COMPLETED Pembrolizumab Plus Chemotherapy in NSCLC With Targetable Genetic Alterations After Progression on Targeted Agents
University of Michigan Rogel Cancer Center
NCT04068896 COMPLETED Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy
NGM Biopharmaceuticals, Inc
NCT06208124 COMPLETED A Study of IMM-6-415 in RAS/RAF Mutant Solid Tumors
Immuneering Corporation
NCT04442126 TERMINATED A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors
Numab Therapeutics AG
NCT03704688 COMPLETED Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT04383938 COMPLETED Phase 1/2 Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies
Aprea Therapeutics
NCT02521051 TERMINATED Phase I/II Trial of Alectinib and Bevacizumab in Patients With Advanced, Anaplastic Lymphoma Kinase (ALK)-Positive, Non-Small Cell Lung Cancer
Massachusetts General Hospital
NCT04967417 COMPLETED Pembrolizumab With Standard Cytotoxic Chemotherapy in Treatment Naive NSCLC Patients With Asymptomatic Brain Metastases
Samsung Medical Center
NCT04075396 COMPLETED A Study of Lazertinib in Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Positive Advanced Non-Small Cell Lung Cancer (NSCLC)
Janssen Research & Development, LLC
NCT06522360 WITHDRAWN Brigatinib Plus Chemotherapy or Local Consolidation Therapy in ALK Positive Advanced Non-small Cell Lung Cancer (BrightStar-2)
M.D. Anderson Cancer Center
NCT05275673 TERMINATED A Study of Sapanisertib in Relapsed/Refractory NFE2L2-Mutated and Wild-Type Squamous Non-Small Cell Lung Cancer
Faeth Therapeutics
NCT04892472 TERMINATED EF-36/Keynote B36: A Pilot, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Pembrolizumab for First Line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer
NovoCure GmbH
NCT04875806 TERMINATED A Safety and Tolerability Study of NC762 in Subjects With Advanced or Metastatic Solid Tumors
NextCure, Inc.
NCT04925986 TERMINATED Sitravatinib Plus Pembrolizumab in Patients With Advanced Treatment-Naïve PD-L1+ Non-Squamous NSCLC
Sarah Goldberg
NCT04485026 WITHDRAWN Local Consolidative Radiotherapy for Oligoprogressive in Non-small Cell Lung Carcinoma
Wake Forest University Health Sciences
NCT06094296 TERMINATED A Study of BMS-986315 and Nivolumab in Combination With Chemotherapy in Participants With First-line Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Bristol-Myers Squibb
NCT04720976 COMPLETED JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors
Allist Pharmaceuticals, Inc.
NCT03732274 COMPLETED Phase 1b/2a, Open-label Study of Vactosertib in Combination With Durvalumab in Advanced NSCLC
MedPacto, Inc.
NCT03445000 TERMINATED ALEctinib for the Treatment of Pretreated RET-rearranged Advanced Non-small Cell Lung Cancer
ETOP IBCSG Partners Foundation
NCT04364620 COMPLETED AB-16B5 Combined With Docetaxel in Subjects With Metastatic Non-Small Cell Lung Cancer (EGIA-002)
Alethia Biotherapeutics
NCT03197467 COMPLETED Neoadjuvant Anti PD-1 Immunotherapy in Resectable Non-small Cell Lung Cancer
AIO-Studien-gGmbH
NCT03452592 TERMINATED Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer Patients With T790M
Allist Pharmaceuticals, Inc.
NCT04512430 TERMINATED Neo-DIANA: Neoadjuvant Treatment for EGFR Mutated Patients
Fundación GECP
NCT03829501 TERMINATED A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies
Kymab Limited
NCT04111705 COMPLETED Lorlatinib After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancer
Intergroupe Francophone de Cancerologie Thoracique
NCT04735068 COMPLETED Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer
Abramson Cancer Center at Penn Medicine
NCT05298176 COMPLETED Combining Afatinib and Concurrent Chemotherapy, Followed by Osimertinib and Concurrent Chemotherapy, in Untreated EGFR Positive NSCLC Tumors
Amsterdam UMC, location VUmc
NCT03631784 COMPLETED A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III NSCLC (KEYNOTE-799, MK-3475-799)
Merck Sharp & Dohme LLC
NCT02582125 COMPLETED ONO-4538 Study in Patients With Advanced Non-Small Cell Lung Cancer
Ono Pharmaceutical Co. Ltd
NCT04003246 COMPLETED Phase II Concurrent Durvalumab and Radiotherapy for for Stage III Non-Small Cell Lung Cancer
University of Texas Southwestern Medical Center
NCT02437136 COMPLETED Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)
Syndax Pharmaceuticals
NCT05543629 TERMINATED A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer
Bristol-Myers Squibb
NCT04832854 COMPLETED A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer
Hoffmann-La Roche
NCT02489903 COMPLETED RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)
EpicentRx, Inc.
NCT04629339 TERMINATED Study of INCB086550 in Select Solid Tumors
Incyte Corporation
NCT05058560 COMPLETED Tislelizumab in Addition to BACE in Patients with NSCLC
The First Affiliated Hospital of Zhengzhou University
NCT04032847 TERMINATED ATL001 in Patients With Advanced Unresectable or Metastatic NSCLC
Achilles Therapeutics UK Limited
NCT04032704 TERMINATED A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors
Seagen Inc.
NCT05061017 COMPLETED Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/Refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (mCRC)
Diwakar Davar
NCT03496766 TERMINATED Tipifarnib in Advanced Squamous NSCLC With Oncogen HRAS MutAtionS
Spanish Lung Cancer Group
NCT04495894 TERMINATED Pre-Incisional Ketorolac for Patients Undergoing Surgery for Non-Small Cell Lung Cancer and Renal Cell Carcinoma
Emory University
NCT04880863 COMPLETED NAP in Combination With Docetaxel Following Obinutuzumab Pretreatment in Subjects With Checkpoint Inhibitor Pretreated Advanced or Metastatic NSCLC
NeoTX Therapeutics Ltd.
NCT03543683 COMPLETED Combination of Osimertinib and Aspirin to Treat 1st Generation EGFR-TKI Resistance in NSCLC
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT02424617 COMPLETED A Study of BGB324 (Bemcentinib) in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer
BerGenBio ASA
NCT04997382 COMPLETED Chemotherapy Combined with ICIs in First-line Alectinib Failed Patients with ALK-rearranged NSCLC
Hunan Province Tumor Hospital
NCT03574649 WITHDRAWN QUILT-2.024: Phase 2 Neoadjuvant, Consolidation, and Adjuvant Combination NANT Immunotherapy Versus Standard of Care in Subjects With Resectable Non-small Cell Lung Cancer
ImmunityBio, Inc.
NCT03169738 WITHDRAWN QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors
ImmunityBio, Inc.
NCT05062980 TERMINATED Quaratusugene Ozeplasmid (Reqorsa) in Combination With Pembrolizumab in Previously Treated Non-Small Lung Cancer
Genprex, Inc.
NCT02597946 COMPLETED Afatinib in NSCLC With HER2 Mutation
Boehringer Ingelheim
NCT03190174 COMPLETED Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers
Sarcoma Oncology Research Center, LLC
NCT03669523 COMPLETED Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS)
Centre Hospitalier Annecy Genevois
NCT03414814 COMPLETED Osimertinib for NSCLC With EGFR Exon 20 Insertion Mutation
Seoul National University Hospital
NCT02733159 COMPLETED Pembrolizumab in Patients With Non-Small Cell Lung Cancer and a Performance Status 2
University of Birmingham
NCT04263051 COMPLETED Evaluation of UCPVax Plus Nivolumab as Second Line Therapy in Advanced Non Small Cell Lung Cancer
Centre Hospitalier Universitaire de Besancon
NCT06191250 TERMINATED --SuPERIOR Trial--
University Health Network, Toronto
NCT04233021 COMPLETED Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation
Intergroupe Francophone de Cancerologie Thoracique
NCT02839265 COMPLETED FLT3 Ligand Immunotherapy and Stereotactic Radiotherapy for Advanced Non-small Cell Lung Cancer
Albert Einstein College of Medicine
NCT03705403 TERMINATED IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study
Maastricht University Medical Center
NCT02841579 COMPLETED Osimertinib (AZD9291) in First-line Locally Advanced or Metastatic NSCLC Patients With EGFR and EGFR T790M
MedSIR
NCT04824079 COMPLETED Keynatinib in Treated Patients With NSCLC and Brain Metastases
Medolution Ltd.
NCT03504488 COMPLETED CAB-ROR2-ADC Safety and Efficacy Study in Patients With TNBC or Head & Neck Cancer (Ph1) and NSCLC or Melanoma (Ph2)
BioAtla, Inc.
NCT04249362 COMPLETED Study of Durvalumab Following Radiation Therapy in Patients With Stage 3 Unresectable NSCLC Ineligible for Chemotherapy
AstraZeneca
NCT02818426 COMPLETED Universal Cancer Peptide-based Vaccination in Metastatic NSCLC
Centre Hospitalier Universitaire de Besancon
NCT03262779 COMPLETED Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer.
Yale University
NCT04245085 COMPLETED ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma
ETOP IBCSG Partners Foundation
NCT05146219 COMPLETED Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation
TYK Medicines, Inc
NCT04731467 COMPLETED A Study of CM24 in Combination with Nivolumab in Adults with Advanced Solid Tumors
Famewave Ltd.
NCT05500508 TERMINATED Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Aminex Therapeutics, Inc.
NCT04889066 WITHDRAWN Durvalumab (MEDI4736) and Radiosurgery (fSRT Vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases
University of Texas Southwestern Medical Center
NCT03625323 COMPLETED Combination Study With Soluble LAG-3 Fusion Protein Eftilagimod Alpha (IMP321) and Pembrolizumab in Patients With Previously Untreated Unresectable or Metastatic NSCLC, or Recurrent PD-X Refractory NSCLC or With Recurrent or Metastatic HNSCC
Immutep S.A.S.
NCT04946019 COMPLETED MR-Linac Guided Adaptive FSRT for Brain Metastases From Non-small Cell Lung Cancer
Sun Yat-sen University
NCT04939701 TERMINATED Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants
Astellas Pharma Global Development, Inc.
NCT04515979 TERMINATED Vactosertib in Combination with Pembrolizumab for PD-L1 Positive Non-small Cell Lung Cancer (NSCLC) Subjects
MedPacto, Inc.
NCT04691388 COMPLETED A Trial of Sintilimab Plus Anlotinib For Metastatic NSCLC After First-Line PD-1 Inhibitor
Zhejiang Cancer Hospital
NCT03081689 COMPLETED Neo-Adjuvant Immunotherapy With Nivolumab for Non Small Cell Lung Cancer Patients
Spanish Lung Cancer Group
NCT03523702 COMPLETED The Selective Personalized Radio-Immunotherapy for Locally Advanced NSCLC Trial
Albert Einstein College of Medicine
NCT06068153 WITHDRAWN AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC
ETOP IBCSG Partners Foundation
NCT02500927 TERMINATED A Study of ASP8273 in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-Naïve Patients With Non-Small Cell Lung Cancer Harboring EGFR Mutations
Astellas Pharma Inc
NCT05898763 COMPLETED TEIPP Immunotherapy in Patients With NSCLC
Erasmus Medical Center
NCT03486730 COMPLETED BT1718 in Patients with Advanced Solid Tumours.
Cancer Research UK
NCT03217071 COMPLETED Pembrolizumab With and Without Radiotherapy for Non-Small Cell Lung Cancer
Sue Yom
NCT03293680 COMPLETED Pembrolizumab in Elderly Patients With Advanced Lung Cancer
Spanish Lung Cancer Group
NCT03239340 COMPLETED A Molecular Profiling Study of Patients With EGFR Mutation-positive Locally Advanced or Metastatic NSCLC Treated With Osimertinib
AstraZeneca
NCT05012397 TERMINATED Milademetan in Advanced/Metastatic Solid Tumors
Rain Oncology Inc
NCT05492045 TERMINATED A Study to Evaluate D-1553 in Combination Therapy in Non-Small Cell Lung Cancer
InventisBio Co., Ltd
NCT05383898 COMPLETED Study to Evaluate D-1553 in Subjects With Lung Cancer
InventisBio Co., Ltd
NCT03004183 COMPLETED SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC
The Methodist Hospital Research Institute
NCT03526900 COMPLETED Atezolizumab in Combination With Carboplatin Plus Pemetrexed in Chemotherapy-naïve Patients With Asymptomatic Brain Metastasis
Spanish Lung Cancer Group
NCT03207867 TERMINATED A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma
Novartis Pharmaceuticals
NCT04323436 TERMINATED Study of Capmatinib and Spartalizumab/Placebo in Advanced NSCLC Patients With MET Exon 14 Skipping Mutations
Novartis Pharmaceuticals
NCT04139317 TERMINATED Safety and Efficacy of Capmatinib (INC280) Plus Pembrolizumab vs Pembrolizumab Alone in NSCLC With PD-L1≥ 50%
Novartis Pharmaceuticals
NCT03583086 COMPLETED Phase I/II Eval Safety & Prelim Activity Nivolumab Comb W/Vorolanib Pts W/Refractory Thoracic Tumors
Vanderbilt-Ingram Cancer Center
NCT05718297 WITHDRAWN Brigatinib Post Definitive Chemo-radiotherapy in Patients with ALK-fusion Non-small Cell Lung Cancer
ETOP IBCSG Partners Foundation
NCT03822351 COMPLETED Durvalumab Alone or in Combination With Novel Agents in Subjects With NSCLC
MedImmune LLC
NCT05397171 TERMINATED A First-in-human Study to Evaluate the Safety and Tolerability of AZD8853 in Participants With Selected Advanced/Metastatic Solid Tumours
AstraZeneca
NCT02264210 COMPLETED Icotinib for Completed Resected IB NSCLC With EGFR Mutation
Sun Yat-sen University
NCT03565003 COMPLETED A First-in-Human Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors in China
Jacobio Pharmaceuticals Co., Ltd.
NCT02250326 COMPLETED Safety and Efficacy Study of Nab®-Paclitaxel With CC-486 or Nab®-Paclitaxel With Durvalumab, and Nab®-Paclitaxel Monotherapy as Second/Third-line Treatment for Advanced Non-small Cell Lung Cancer
Celgene
NCT06064279 WITHDRAWN Harnessing Allo-immunity to Enhance Immune Checkpoint Inhibitor Responses in Advanced NSCLC
VA Office of Research and Development
NCT05757843 WITHDRAWN Using Circulating Tumor DNA to Personalize Duration of Consolidation Durvalumab
Indiana University
NCT02927301 COMPLETED A Study of Atezolizumab as Neoadjuvant and Adjuvant Therapy in Resectable Non-Small Cell Lung Cancer (NSCLC) - Lung Cancer Mutation Consortium (LCMC3)
Genentech, Inc.
NCT03955198 COMPLETED A Trial Evaluating Stereotactic Radiotherapy Plus Durvalumab Continuation for Patients With NSCLC Metachronous Oligometastatic Disease Under Durvalumab Consolidation Following Chemoradiation
Institut Claudius Regaud
NCT02855125 COMPLETED A Randomized Phase 2 Trial of TAS-114 in Combination With S-1 Versus S-1
Taiho Oncology, Inc.
NCT04721223 COMPLETED JAB-3068 Activity in Adult Patients With Advanced Solid Tumors
Jacobio Pharmaceuticals Co., Ltd.
NCT02664181 COMPLETED Rational EpigenetiC Immunotherapy for SEcond Line Therapy in Patients With NSCLC: PRECISE Trial
Case Comprehensive Cancer Center
NCT04944173 WITHDRAWN SCION: SABR and Checkpoint Inhibition of NSCLC
University of British Columbia
NCT03473925 COMPLETED Efficacy and Safety Study of Navarixin (MK-7123) in Combination With Pembrolizumab (MK-3475) in Adults With Selected Advanced/Metastatic Solid Tumors (MK-7123-034)
Merck Sharp & Dohme LLC
NCT03664024 COMPLETED Biomarkers of Response to Pembrolizumab Combined With Chemotherapy in Non-Small Cell Lung Cancer (KEYNOTE-782, MK-3475-782)
Merck Sharp & Dohme LLC
NCT03267316 COMPLETED A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors
Cantargia AB
NCT02420314 COMPLETED Pharmacological Ascorbate for Lung Cancer
Joseph J. Cullen, MD, FACS
NCT04764214 COMPLETED SRT for Residual Oligometastases of NSCLC After 3rd Generation EGFR-TKIs
Fudan University
NCT04770688 COMPLETED Advanced Lung Tumor Treated by Osimertinib Plus Anlotinib
Shanghai Chest Hospital
NCT03050554 TERMINATED SBRT Combined With Avelumab (Anti-PD-L1) for Management of Early Stage Non-Small Cell Lung Cancer (NSCLC)
Andrew Sharabi
NCT06332300 WITHDRAWN An Exploratory Clinical Study of Adebelimumab in Combination With Famitinib and Chemotherapy in Patients With NSCLC
Jiangsu Province Nanjing Brain Hospital
NCT04144608 COMPLETED Toripalimab Combined With Double Platinum-based Chemotherapy for Initially Unresectable NSCLC
Yongchang Zhang
NCT05068427 COMPLETED Trial of Chidamide in Combination With Envafolimab in Patients With PD-1 Inhibitor Resistant Advanced NSCLC.
Chipscreen Biosciences, Ltd.
NCT03689855 COMPLETED Ramucirumab and Atezolizumab After Progression on Any Immune Checkpoint Blocker in NSCLC
Washington University School of Medicine
NCT06521034 COMPLETED First-in-Human Phase I/II Study of FHND-9041 in Patients With EGFR Mutated Advanced Non-Small Cell Lung Cancer
Yongchang Zhang
NCT06507891 TERMINATED A Clinical Study to Evaluate the Tolerance, Pharmacokinetics and Efficacy of TQ-A3334 Tablets
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
NCT04480372 COMPLETED SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II
Swiss Cancer Institute
NCT04908956 TERMINATED Osimertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR Mutant NSCLC (STEREO)
ETOP IBCSG Partners Foundation
NCT02978404 COMPLETED Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases
Centre hospitalier de l'Université de Montréal (CHUM)
NCT02949843 TERMINATED Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations
Wake Forest University Health Sciences
NCT04402008 TERMINATED Study of Poziotinib in Japanese Patients With NSCLC
Spectrum Pharmaceuticals, Inc
NCT03968419 TERMINATED This Study Will Evaluate the Effect of Canakinumab or Pembrolizumab Given as Monotherapy or in Combination as Neo-adjuvant Treatment for Subjects With Early Stages NSCLC.
Novartis Pharmaceuticals
NCT03693300 COMPLETED A Study to Determine Safety of Durvalumab After Sequential Chemo Radiation in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
AstraZeneca
NCT05567055 WITHDRAWN Central Nervous System Efficacy of Capmatinib in NSCLC With Brain Metastases With cfDNA Positive MET Alterations
Timothy Burns, MD, PHD
NCT04037462 TERMINATED Induction of Sensecence Using Dexamethasone to Re-sensitize NSCLC to Anti-PD1 Therapy
VA Office of Research and Development
NCT03095612 TERMINATED Phase 1/2 Trial of Selinexor (KPT-330) With Docetaxel for Non-small Cell Lung Cancer (NSCLC)
University of Texas Southwestern Medical Center
NCT04161391 TERMINATED Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations
Turning Point Therapeutics, Inc.
NCT03481114 COMPLETED Patient-Reported Outcomes Following Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer
Albert Einstein College of Medicine
NCT03497767 COMPLETED A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases
Trans Tasman Radiation Oncology Group
NCT02350764 COMPLETED Evaluate the Mediators of Sensitivity and Resistance to Nivolumab Plus Ipilimumab in Patients With Advanced NSCLCs
Memorial Sloan Kettering Cancer Center
NCT05999357 WITHDRAWN JDQ443 for KRAS G12C NSCLC Brain Metastases
Maastricht University Medical Center
NCT04549025 TERMINATED Study of PD-1 Inhibitor JTX-4014 Alone and in Combination With Vopratelimab in Biomarker-selected Subjects With Metastatic NSCLC After One Prior Platinum-containing Regimen
Jounce Therapeutics, Inc.
NCT04426825 COMPLETED A Study of Atezolizumab in Combination With Bevacizumab in Patients With EGFR Mutation Positive Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
NCT03001882 COMPLETED An Exploratory Study of the Effects of Nivolumab Combined With Ipilimumab in Patients With Treatment-Naive Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC)
Bristol-Myers Squibb
NCT03810066 COMPLETED Exploring the Theragnostic Value of Osimertinib in EGFR-mutated Lung Cancer (THEROS)
University Hospital, Essen
NCT04263090 COMPLETED Rigosertib Plus Nivolumab for KRAS+ NSCLC Patients Who Progressed on First-Line Treatment
Icahn School of Medicine at Mount Sinai
NCT03410108 COMPLETED Phase 2 Study of Brigatinib in Japanese Participants With Anaplastic Lymphoma Kinase (ALK)-Positive Non-Small Cell Lung Cancer (NSCLC)
Takeda
NCT02658097 COMPLETED Pembrolizumab Alone or Sequentially Following Single Fraction Non-ablative Radiation to One of the Target Lesions, in Previously Treated Patients With Stage IV NSCLC
Case Comprehensive Cancer Center
NCT04476797 TERMINATED Phase I/II Study of SBRT and GC4711 for Centrally Located or Large NSCLC
Galera Therapeutics, Inc.
NCT04211922 TERMINATED Alkotinib Capsule in Patients With ALK-positive Non-small Cell Lung Cancer Previously Treated With Crizotinib
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
NCT06331585 WITHDRAWN Effect of Low-dose Radiotherapy on Tumor Immune Microenvironment in Oligometastases of NSCLC After Immunotherapy
Hetian District People's Hospital
NCT05709821 TERMINATED IMM60 and Pembrolizumab in Melanoma and NSCLC
iOx Therapeutics
NCT02954991 TERMINATED Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer
Mirati Therapeutics Inc.
NCT04027946 TERMINATED LMB-100 Followed by Pembrolizumab in the Treatment of Adults With Mesothelin-Expressing Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
National Cancer Institute (NCI)
NCT02920996 TERMINATED Merestinib In Non-Small Cell Lung Cancer And Solid Tumors
Dana-Farber Cancer Institute
NCT03472560 TERMINATED A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF)
Pfizer
NCT03861156 COMPLETED D-0316 in Patients With EGFR Positive Non Small Cell Lung Cancer
InventisBio Co., Ltd
NCT03318939 TERMINATED Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
Spectrum Pharmaceuticals, Inc
NCT03958097 COMPLETED Natural Killer(NK) Cell Combined With Programmed Death-1(PD-1) Antibody as Second Line Therapy for Advanced Driver Mutation Negative Non-small Cell Lung Cancer
The First Hospital of Jilin University
NCT05815186 WITHDRAWN Ladarixin With Sotorasib in Advanced NSCLC - Phase II
NYU Langone Health
NCT05705466 WITHDRAWN Study of Navtemadlin Plus Pembrolizumab as Maintenance Therapy in Locally Advanced and Metastatic Non-Small Cell Lung Cancer
Kartos Therapeutics, Inc.
NCT02337530 COMPLETED Selumetinib in Patients Receiving Pemetrexed and Platinum-based Chemotherapy in Advanced or Metastatic KRAS Wildtype or Unknown Non-Squamous NSCLC
Canadian Cancer Trials Group
NCT02414139 COMPLETED Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1)
Novartis Pharmaceuticals
NCT04212052 COMPLETED Split-course Hypofractionated Radiotherapy With Concurrent Chemotherapy in Locally Advanced Non-small Cell Lung Cancer
Sun Yat-sen University
NCT04102436 WITHDRAWN Non-Viral TCR Gene Therapy
National Cancer Institute (NCI)
NCT03744715 TERMINATED A Study to Allow Continued Dosing and/or Follow-up of Patients Who Have Had Previous Exposure to Poziotinib
Spectrum Pharmaceuticals, Inc
NCT03976518 COMPLETED Atezolizumab in Advanced Non-small Cell Lung Cancer With Rare Histologies (CHANCE Trial)
Gruppo Oncologico Italiano di Ricerca Clinica
NCT05099549 TERMINATED Safety, Tolerability, and Anti-Tumor Activity of AFM24 in Combination With SNK01 in Subjects With Advanced/Metastatic EGFR-Expressing Cancers
NKGen Biotech, Inc.
NCT03257722 TERMINATED Pembrolizumab + Idelalisib for Lung Cancer Study
Asha Nayak
NCT04491084 TERMINATED FLT3 Ligand, CD40 Agonist Antibody, and Stereotactic Radiotherapy
Albert Einstein College of Medicine
NCT05005273 COMPLETED A Study to Assess BMS-986207 in Combination With Nivolumab and Ipilimumab as First-line Treatment for Participants With Stage IV Non-Small Cell Lung Cancer
Bristol-Myers Squibb
NCT04577638 COMPLETED Accelerated Radio-Immunotherapy for Lung Cancer
Center Eugene Marquis
NCT05176925 TERMINATED Tislelizumab Combined With Sitravatinib as Consolidation Treatment Following Concurrent Chemoradiation in Patients With Locally Advanced, Unresectable NSCLC
Fudan University
NCT02567799 COMPLETED BIO 300 Non-Small Cell Lung Cancer Study
Humanetics Corporation
NCT03543813 COMPLETED PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL
CytomX Therapeutics
NCT03511391 COMPLETED CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors
University Hospital, Ghent
NCT03087760 COMPLETED Trial of Consolidation Pembrolizumab After Concurrent Chemotherapy and Proton Reirradiation for Thoracic Recurrences of Non-Small Cell Lung Cancer
Abramson Cancer Center at Penn Medicine
NCT03083691 COMPLETED BIOLUMA: Biomarkers for Nivolumab and Ipilimumab and Evaluation of the Combination in Lung Cancer
Lung Cancer Group Cologne
NCT03840902 TERMINATED M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC)
EMD Serono Research & Development Institute, Inc.
NCT04620330 COMPLETED A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer
Verastem, Inc.
NCT02879617 COMPLETED A Clinical Trial of Durvalumab (MEDI4736) as 1st Line Therapy in Advanced Non-small Cell Lung Cancer Patients
Academic Thoracic Oncology Medical Investigators Consortium
NCT02581943 COMPLETED Effect of Pembrolizumab With or Without Carboplatin and Paclitaxel on Immune Response in Patients With Recurrent or Stage IIIB-IV Non-small Cell Lung Cancer
Wake Forest University Health Sciences
NCT03149549 TERMINATED PROCLAIM-CX-2009: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2009 for Patients With Selected Solid Tumors
CytomX Therapeutics
NCT04271384 COMPLETED Stereotactic Ablative Radiotherapy With Nivolumab for Early-Stage Operable Non-Small Cell Lung Cancer
Hospital Israelita Albert Einstein
NCT04099836 TERMINATED Atezolizumab and Bevacizumab in EGFR Mutant NSCLC in Patients With Progressive Disease After Receiving Osimertinib
Duke University
NCT03123783 COMPLETED CD40 Agonistic Antibody APX005M (Sotigalimab) in Combination With Nivolumab
Apexigen America, Inc.
NCT04151563 WITHDRAWN A Clinical Study Evaluating Nivolumab-containing Treatments in Patients With Advanced Non-small Cell Lung Cancer After Failing Previous PD-1/(L)1 Therapy and Chemotherapy
Bristol-Myers Squibb
NCT02531854 WITHDRAWN A Study of Pemetrexed Maintenance With or Without ADXS11-001 Immunotherapy in Patients With Human Papillomavirus Positive (HPV+), NSCLC Following First-Line Induction Chemotherapy
Advaxis, Inc.
NCT03845270 COMPLETED Her2-positive Lung Cancer Treated With Dedicated Drug
Intergroupe Francophone de Cancerologie Thoracique
NCT03386929 TERMINATED Survival Prolongation by Rationale Innovative Genomics
Worldwide Innovative Network Association
NCT04311034 COMPLETED A Study of RC48-ADC in Subjects With Advanced Non-small Cell Lung Cancer
RemeGen Co., Ltd.
NCT05948462 WITHDRAWN Lorlatinib in Combination With Chemotherapy in Participants With Metastatic Anaplastic Lymphoma Kinase Positive (ALK+) Non-small Cell Lung Cancer (NSCLC) Who Progressed on Single-agent Lorlatinib
SCRI Development Innovations, LLC
NCT03014648 COMPLETED Evaluating the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer (NSCLC)
Liza Villaruz, MD
NCT02716038 COMPLETED Neoadjuvant MPDL3280A, Nab-paclitaxel and Carboplatin (MAC) in NSCLC
Columbia University
NCT02312622 COMPLETED Phase 2 Etirinotecan Pegol in Refractory Brain Metastases & Advanced Lung Cancer / Metastatic Breast Cancer
Joel Neal
NCT03673657 COMPLETED Study of Early Nutritional Intervention During Concurrent Chemoradiotherapy for Local Advanced Non-small Cell Lung Cancer
Sun Yat-sen University
NCT02183883 COMPLETED Deciphering Afatinib Response and Resistance With INtratumour Heterogeneity
University College, London
NCT04785365 TERMINATED Long-Term Follow-Up Study of Patients Receiving ATL001
Achilles Therapeutics UK Limited
NCT03409458 COMPLETED A Dose Escalation and Confirmation Study of PT-112 in Advanced Solid Tumors in Combination With Avelumab
Promontory Therapeutics Inc.
NCT02718066 COMPLETED Study of HBI-8000 With Nivolumab in Melanoma, Renal Cell Carcinoma and Non-Small Cell Lung Cancer
HUYABIO International, LLC.
NCT03871153 TERMINATED Chemoradiation Plus Durvalumab Followed by Surgery Followed by Adjuvant Durvalumab in Patients With Surgically Resectable Stage III (N2) Non-Small Cell Lung Cancer
Greg Durm, MD
NCT03228186 TERMINATED Trial of Pevonedistat Plus Docetaxel in Patients With Previously Treated Advanced Non-Small Cell Lung Cancer
University of Michigan Rogel Cancer Center
NCT06090318 WITHDRAWN Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss
Rain Oncology Inc
NCT04739358 TERMINATED CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC
Criterium, Inc.
NCT05180422 WITHDRAWN A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis
Criterium, Inc.
NCT03727724 COMPLETED Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer
The Netherlands Cancer Institute
NCT03434418 COMPLETED A Study Osimertinib in Patients With Stage 4 Non-small Cell Lung Cancer With Uncommon EGFR Mutations
Duke University
NCT02426658 COMPLETED Pemetrexed Disodium in Treating Patients With Stage IV Non-small Cell Lung Cancer and ECOG Performance Status 3
Wake Forest University Health Sciences
NCT02904954 COMPLETED Durvalumab (MEDI4736) With or Without SBRT in Clinical Stage I, II and IIIA Non-small Cell Lung Cancer
Weill Medical College of Cornell University
NCT02803203 COMPLETED Osimertinib and Bevacizumab as Treatment for EGFR-mutant Lung Cancers
Memorial Sloan Kettering Cancer Center
NCT02439450 COMPLETED A Study of Combination Therapies With Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer
Heat Biologics
NCT03953235 COMPLETED A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens
Gritstone bio, Inc.
NCT03639714 COMPLETED A Study of a Personalized Neoantigen Cancer Vaccine
Gritstone bio, Inc.
NCT02343952 COMPLETED Consolidation Pembrolizumab Following Chemoradiation in Patients With Inoperable/Unresectable Stage III NSCLC
Nasser Hanna, M.D.
NCT03425006 TERMINATED Pembrolizumab and Itacitinib (INCB039110) for Non-Small Cell Lung Cancer
University of Pennsylvania
NCT04422392 TERMINATED Neoadjuvant PD-1 Antibody Plus Chemotherapy in Resectable Stage IIIA-N2 Non-Small-Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
NCT03317496 TERMINATED Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies
Pfizer
NCT02658890 COMPLETED An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread
Bristol-Myers Squibb
NCT04345146 COMPLETED Bevacizumab Combined With Fractionated Stereotactic Radiotherapy for 1 to 10 Brain Metastases From NSCLC
Sun Yat-sen University
NCT03513666 COMPLETED A Study of Toripalimab+ Pemetrexed Plus Carboplatin in Patients With EGFR-mutation Positive and T790M Negative After Progression on EGFR-TKI Treatment
Shanghai Junshi Bioscience Co., Ltd.
NCT03840915 COMPLETED M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC)
EMD Serono Research & Development Institute, Inc.
NCT03417882 TERMINATED GRN-1201 With Pembrolizumab in Subjects With Metastatic PD-L1+ NSCLC
BrightPath Biotherapeutics
NCT03520842 COMPLETED Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer
Stanford University
NCT02988817 COMPLETED Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors
Genmab
NCT03576131 TERMINATED GEN1029 (HexaBody®-DR5/DR5) Safety Trial in Patients With Malignant Solid Tumors
Genmab
NCT04424641 TERMINATED A Study on the Safety of GEN1044 (DuoBody®-CD3x5T4) in Patients With Malignant Solid Tumors
Genmab
NCT02710396 TERMINATED Genetic Predictors of Benefit to Pembrolizumab
Columbia University
NCT03679767 COMPLETED A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)
Incyte Corporation
NCT05400577 WITHDRAWN Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC
Fox Chase Cancer Center
NCT02584634 TERMINATED Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)
Pfizer
NCT03735680 COMPLETED A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer
OncoNano Medicine, Inc.
NCT05116891 COMPLETED A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors
Cantargia AB
NCT03805841 TERMINATED Study of Tarloxotinib in Pts With NSCLC (EGFR Exon 20 Insertion, HER2-activating Mutations) & Other Solid Tumors With NRG1/ERBB Gene Fusions
Rain Oncology Inc
NCT02335944 TERMINATED Study of Safety and Efficacy of EGFR-TKI EGF816 in Combination With cMET Inhibitor INC280 in Adult Patients With EGFR Mutated Non Small Cell Lung Cancer.
Novartis Pharmaceuticals
NCT03345810 COMPLETED Durvalumab (MEDI4736) in Frail and Elder Patients With Metastatic NSCLC (DURATION)
AIO-Studien-gGmbH
NCT04471415 TERMINATED Study to Investigate DRP-104 in Adults With Advanced Solid Tumors
Dracen Pharmaceuticals, Inc.
NCT03743129 COMPLETED Anlotinib After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer(ALTER-L029)
Anhui Shi, MD
NCT03827850 TERMINATED FGFR Inhibitor in FGFR Dysregulated Cancer
Lung Cancer Group Cologne
NCT03637803 TERMINATED Live Biotherapeutic Product MRx0518 and Pembrolizumab Combination Study in Solid Tumors
4D pharma plc
NCT03233724 TERMINATED Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas
National Cancer Institute (NCI)
NCT02666105 COMPLETED Exemestane in Post-Menopausal Women With NSCLC
Masonic Cancer Center, University of Minnesota
NCT02607423 WITHDRAWN Fludeoxyglucose F-18 PET/CT in Predicting Response to Chemotherapy in Patients With Stage IIIA Non-small Cell Lung Cancer That Can Be Removed by Surgery
ECOG-ACRIN Cancer Research Group
NCT04507217 COMPLETED Tislelizumab Combined With Pemetrexed/ Carboplatin in Patients With Brain Metastases of Non-squamous NSCLC
Sun Yat-sen University
NCT03102242 COMPLETED Atezolizumab Immunotherapy in Patients With Advanced NSCLC
Alliance Foundation Trials, LLC.
NCT02382406 TERMINATED Carboplatin/Nab-Paclitaxel and Pembrolizumab in NSCLC
Nisha Mohindra, MD
NCT03304093 COMPLETED Immunotherapy by Nivolumab for HIV+ Patients
Intergroupe Francophone de Cancerologie Thoracique
NCT03455829 COMPLETED G1T38, a CDK 4/6 Inhibitor, in Combination With Osimertinib in EGFR-Mutant Non-Small Cell Lung Cancer
G1 Therapeutics, Inc.
NCT03802058 TERMINATED Concurrent Nab-P/Carboplatin and Thoracic Radiotherapy in Squamous Cell Lung Cancer
Wuhan University
NCT03168464 TERMINATED Radiation and Immune Checkpoints Blockade in Metastatic NSCLC (BMS # CA209-632)
Weill Medical College of Cornell University
NCT04863248 TERMINATED Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Docetaxel for Metastatic Non-Small Cell Lung Cancer (NSCLC) (PRESERVE 4)
G1 Therapeutics, Inc.
NCT02764086 TERMINATED INTENSE: A Phase I/II Study of INhomogeneous Targeted Dose Escalation in Non-Small CEll Lung Cancer
Cancer Trials Ireland
NCT05792995 COMPLETED Foundation and Clinical About the Expression of PD-1 in Peripheral Blood T Lymphocytes
Xin-Hua Xu
NCT05212922 WITHDRAWN A Study to Evaluate YH001 in Combination With Toripalimab in Subjects With Advanced NSCLC and HCC
Eucure (Beijing) Biopharma Co., Ltd
NCT02771626 TERMINATED Study CB-839 in Combination With Nivolumab in Patients With Melanoma, Clear Cell Renal Cell Carcinoma (ccRCC) and Non-Small Cell Lung Cancer (NSCLC)
Calithera Biosciences, Inc
NCT03030131 TERMINATED Immune Neoadjuvant Therapy Study of Durvalumab in Early Stage Non-small Cell Lung Cancer
Intergroupe Francophone de Cancerologie Thoracique
NCT02983045 COMPLETED A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors
Nektar Therapeutics
NCT03138889 TERMINATED Bempegaldesleukin and Pembrolizumab With or Without Chemotherapy in Locally Advanced or Metastatic Solid Tumors
Nektar Therapeutics
NCT04749602 COMPLETED Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion.
Kidney Cancer Research Bureau
NCT03825510 COMPLETED Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) Effect
Crozer-Keystone Health System
NCT04650490 WITHDRAWN SRS Timing With Immune Checkpoint Inhibition in Patients With Untreated Brain Metastases From Non-small Cell Lung Cancer
Duke University
NCT03838848 TERMINATED KN046 in Patients With Advanced Non-small Cell Lung Cancer
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
NCT03713944 TERMINATED Carboplatin Plus Pemetrexed Plus Atezolizumab Plus Bevacizumab in Chemotherapy and Immunotherapy-naïve Patients With Stage IV Non-squamous Non-small Cell Lung Cancer
Nasser Hanna
NCT03366480 COMPLETED A Study to Assess the Efficacy and Safety of ABTL0812
Ability Pharmaceuticals SL
NCT04438902 TERMINATED Osimertinib Combined With Anlotinib in EGFR T790M Mutated NSCLC Patients With Progression on Osimertinib Treatment
First Affiliated Hospital of Zhejiang University
NCT03663166 TERMINATED Radiation and Chemotherapy With Ipilimumab Followed by Nivolumab for Patients With Stage III Unresectable Non-Small Cell Lung Cancer (NSCLC)
H. Lee Moffitt Cancer Center and Research Institute
NCT02513667 TERMINATED Ceritinib in Combination With Stereotactic Ablative Radiation Metastatic Lung Adenocarcinoma
University of Texas Southwestern Medical Center
NCT02706626 TERMINATED Trial of Brigatinib After Treatment With Next-Generation ALK Inhibitors
Criterium, Inc.
NCT02713529 COMPLETED Safety and Efficacy Study of AMG 820 and Pembrolizumab Combination in Select Advanced Solid Tumor Cancer
AmMax Bio, Inc.
NCT04297748 TERMINATED Bioimaging Study of 89Zr-M7824 in NSCLC
Olivia Newton-John Cancer Research Institute
NCT02454842 TERMINATED Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients
Rain Oncology Inc
NCT03693547 COMPLETED Clinical Study of Utidelone Injection in Patients With Advanced Non-small Cell Lung Cancer(NSCLC)
Beijing Biostar Pharmaceuticals Co., Ltd.
NCT02591615 COMPLETED Optimal Sequencing of Pembrolizumab (MK-3475) and Standard Platinum-based Chemotherapy in First-Line NSCLC
Alliance Foundation Trials, LLC.
NCT04444427 COMPLETED Evaluation of GLR2007 for Advanced Solid Tumors
Gan and Lee Pharmaceuticals, USA
NCT05219578 TERMINATED RTX-224 Monotherapy in Patients With Solid Tumors
Rubius Therapeutics
NCT03853187 COMPLETED Imaging Tumor-infiltrating T-cells in Non-small Cell Lung Cancer
Radboud University Medical Center
NCT03090737 COMPLETED Safety Study of Nivolumab to Treat Advanced or Metastatic Non-small Cell Lung Cancer
Bristol-Myers Squibb
NCT03661567 TERMINATED Methylprednisolone After Split-course Chemoradiotherapy For Bulky Local Advanced None-small Cell Lung Cancer
Sun Yat-sen University
NCT03360929 COMPLETED Evaluate Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of AZD3759
LYZZ Alpha Holding Ltd
NCT05481775 WITHDRAWN Evaluating Efficacy and Safety of Anlotinib Combined With Concurrent Chemoradiotherapy Followed by Consolidation Immunotherapy for Locally Advanced Non-small Cell Lung Cancer
Sun Yat-sen University
NCT02409368 COMPLETED An Open-Label, Multicenter Clinical Trial With Nivolumab (BMS-936558) Monotherapy in Subjects With Advanced or Metastatic Squamous Cell (Sq) Non-Small Cell Lung Cancer (NSCLC) Who Have Received at Least One Prior Systemic Regimen for the Treatment of Stage IIIb/IV SqNSCLC
Bristol-Myers Squibb
NCT03784599 TERMINATED T-DM1 and Osimertinib Combination Treatment to Target HER2 Bypass Track Resistance in EGFR Mutation Positive NSCLC
The Netherlands Cancer Institute
NCT03762122 TERMINATED Rogaratinib in Patients With Advanced Pretreated Squamous-cell Non-small Cell Lung Cancer (SQCLC)
Swiss Cancer Institute
NCT03900117 COMPLETED Hypofractionated Radiotherapy Followed by Hypo-boost for Local Advanced NSCLC
Sun Yat-sen University
NCT03164772 COMPLETED Phase 1/2 Study of Combination Immunotherapy and Messenger Ribonucleic Acid (mRNA) Vaccine in Subjects With NSCLC
Ludwig Institute for Cancer Research
NCT02898116 COMPLETED Phase 1/2 Study of Ensartinib and Durvalumab, in ALK-rearranged Non-small Cell Lung Cancer
Ludwig Institute for Cancer Research
NCT05383001 WITHDRAWN Randomized Phase II, Open-label Efficacy and Safety Study of Second-line Durvalumab Plus Tremelimumab Versus Platinum-based Chemotherapy Alone in Patients With NSCLC and First-line Checkpoint-inhibitor Therapy (Re-Check)
AIO-Studien-gGmbH
NCT04265534 TERMINATED KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC
Calithera Biosciences, Inc
NCT03965845 COMPLETED A Study of Telaglenastat (CB-839) in Combination With Palbociclib in Patients With Solid Tumors
Calithera Biosciences, Inc
NCT02967133 TERMINATED A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer
Alliance Foundation Trials, LLC.
NCT02369484 COMPLETED Afatinib in NSCLC With HER2 Mutation
ETOP IBCSG Partners Foundation
NCT02434081 COMPLETED NIvolumab COmbination With Standard First-line Chemotherapy and Radiotherapy in Locally Advanced Stage IIIA/B Non-Small Cell Lung Carcinoma
ETOP IBCSG Partners Foundation
NCT05091528 TERMINATED A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive Cancers
Silverback Therapeutics
NCT02716311 COMPLETED Combination of Cetuximab With Afatinib for Patient With EGFR Mutated Lung Cancer
Intergroupe Francophone de Cancerologie Thoracique
NCT04069936 TERMINATED Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLC
WindMIL Therapeutics
NCT03041181 TERMINATED Single Agent Chemotherapy +/- Nivolumab in Patients With Advanced Squamous or Non-squamous NSCLC With Primary Resistance to Prior PD-1 or PDL-1 Inhibitor
Nasser Hanna, M.D.
NCT03623750 COMPLETED E GFR TKI and EGF-P TI C Ombination in EGFR mutA nt NSCL C
Instituto Oncológico Dr Rosell
NCT04507906 COMPLETED Nivolumab Combined With Anlotinib as Re-challenge Treatment in Advanced NSCLC
Shanghai Chest Hospital
NCT02648724 COMPLETED Sym015 (Anti-MET) in Patients With Advanced Solid Tumor Malignancies
Symphogen A/S
NCT03091491 TERMINATED Study of Nivolumab Verses Nivolumab and Ipilimumab Combination in EGFR Mutant Non-small Cell Lung Cancer
National Cancer Centre, Singapore
NCT03717155 COMPLETED Study of Avelumab and Cetuximab Plus Gemcitabine and Cisplatin in Participants With NSCLC
Merck KGaA, Darmstadt, Germany
NCT02684461 COMPLETED Phase II Trial of Sequential Consolidation With Pembrolizumab Followed by Nab-paclitaxel
UNC Lineberger Comprehensive Cancer Center
NCT03904108 TERMINATED Platinum-Based Chemotherapy Plus Ramucirumab in Patients With Advanced NSCLC Who Have Progressed on First Line Anti-PD-1 Immunotherapy
ROGER S KERESZTES MD
NCT03812809 COMPLETED A Phase IIb Study of BPI-7711 Capsule in Non-small Cell Lung Cancer Patients With T790M Mutation Positive
Beta Pharma Shanghai
NCT03386955 COMPLETED BPI-7711 Capsule in Patients With EGFR Mutation T790M Positive Non-small Cell Lung Cancer
Beta Pharma Shanghai
NCT03367819 TERMINATED Isatuximab in Combination With REGN2810 (Cemiplimab) in Patients With Advanced Malignancies
Sanofi
NCT03801304 COMPLETED Trial to Evaluate Safety and Efficacy of Vinorelbine With Metronomic Administration in Combination With Atezolizumab as Second-line Treatment for Patients With Stage IV Non-small Cell Lung Cancer
University Hospital, Brest
NCT03268057 COMPLETED VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer
Vaccinex Inc.
NCT04841538 WITHDRAWN A Study of ES101 (PD-L1x4-1BB Bispecific Antibody) in Patients With Advanced Malignant Thoracic Tumors
Elpiscience Biopharma, Ltd.
NCT03562871 COMPLETED IO102 With Pembrolizumab, With or Without Chemotherapy, as First-line Treatment of Metastatic NSCLC
IO Biotech
NCT03633110 COMPLETED Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine
Genocea Biosciences, Inc.
NCT02347917 COMPLETED A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma
Sumitomo Pharma Co., Ltd.
NCT05234606 WITHDRAWN A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1 Inhibitors in Select Advanced Solid Tumors
Silverback Therapeutics
NCT04754815 WITHDRAWN Study of Pembrolizumab With Single Agent Chemotherapy in Elderly Patients With Advanced NSCLC
Shirish Gadgeel
NCT03770299 WITHDRAWN An Investigational Immuno-therapy Study of Nivolumab Given After Surgery in Non-Small Cell Lung Cancer (NSCLC) Participants With Minimal Residual Disease
Bristol-Myers Squibb
NCT02662634 WITHDRAWN A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer
GU Research Network, LLC
NCT02616393 COMPLETED Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases
Kadmon Corporation, LLC
NCT02459067 TERMINATED ImmuniCell® in Patients With Advanced Cancers
TC Biopharm
NCT04470674 WITHDRAWN Study of Durvalumab or Durvalumab Plus Chemotherapy in Kras Mutation Positive and PD-L1 High (≥ 50%) NSCLC Patients
Shirish M Gadgeel
NCT03798743 COMPLETED Phase II Study on Sintilimab Combined With Docetaxel for Chemotherapy Failure Advanced NSCLC: the SUCCESS Study
Hunan Province Tumor Hospital
NCT04144582 COMPLETED Sintilimab Combined With Docetaxel for Standard Chemotherapy Failure Non-driver Gene Mutation Metastatic Non-small Cell Lung Cancer
Yongchang Zhang
NCT02323126 TERMINATED Study of Efficacy and Safety of Nivolumab in Combination With EGF816 and of Nivolumab in Combination With INC280 in Patients With Previously Treated Non-small Cell Lung Cancer
Novartis Pharmaceuticals
NCT04958993 TERMINATED A Trial of Anlotinib Combined With Concurrent Chemoradiotherapy in Patients With Unresectable Stage III Non-small Cell Lung Cancer
Shandong Cancer Hospital and Institute
NCT03794544 COMPLETED Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer
MedImmune LLC
NCT03647488 COMPLETED Study of Capmatinib and Spartalizumab Combination Therapy vs Docetaxel in Non-small Cell Lung Cancer
Novartis Pharmaceuticals
NCT03353675 COMPLETED A Study Evaluating the Efficacy and the Safety of First-line Chemotherapy Combined With the Therapeutic Vaccine Named TG4010 and Nivolumab in Patients With Advanced Non-squamous Non-Small Cell Lung Cancer (NSCLC)
Transgene
NCT04758949 WITHDRAWN FL-101 in Surgically Resectable Non-Small Cell Lung Cancer
Flame Biosciences
NCT03319316 WITHDRAWN Combination of Durvalumab and Tremelimumab as Maintenance Treatment in Patients With Non Squamous and Squamous (NSCLC)
European Organisation for Research and Treatment of Cancer - EORTC
NCT02564380 TERMINATED Study of Pembrolizumab Maintenance Following First-Line Platinum Based Chemotherapy in Patients With Metastatic Squamous - Non-Small Cell Lung Cancer (sNSCLC)
AIO-Studien-gGmbH
NCT03659578 COMPLETED Study of Thymosin α1 to Reduce Acute Pneumonia For Bulky None-small Cell Lung Cancer
Sun Yat-sen University
NCT04165031 TERMINATED A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
Eli Lilly and Company
NCT05007769 WITHDRAWN Ramucirumab, Atezolizumab and N-803 After Progression on Any Immune Checkpoint Blocker in NSCLC
Washington University School of Medicine
NCT02387216 TERMINATED A Study of MM-121 in Combination With Chemotherapy Versus Chemotherapy Alone in Heregulin Positive NSCLC
Elevation Oncology
NCT03131206 TERMINATED A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer
Dana-Farber Cancer Institute
NCT03261947 COMPLETED A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors
Millennium Pharmaceuticals, Inc.
NCT02408016 TERMINATED Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma
Fred Hutchinson Cancer Center
NCT02423343 COMPLETED A Study of Galunisertib (LY2157299) in Combination With Nivolumab in Advanced Refractory Solid Tumors and in Recurrent or Refractory NSCLC, or Hepatocellular Carcinoma
Eli Lilly and Company
NCT04430933 WITHDRAWN A Safety and Tolerability Study of NC318 in Combination With Chemotherapy for Subjects With Advanced or Metastatic NSCLC
NextCure, Inc.
NCT02450539 COMPLETED A Study of Abemaciclib (LY2835219) in Participants With Stage IV Squamous Non-small Cell Lung Cancer
Eli Lilly and Company
NCT02879994 COMPLETED Pembrolizumab in Treating Patients With EGFR Mutant, Tyrosine Kinase Inhibitor Naive Advanced Non-Small Cell Lung Cancer
Jonsson Comprehensive Cancer Center
NCT02349633 TERMINATED Study For Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M)
Pfizer
NCT02804776 COMPLETED PRe-Operative Gefitinib in Resectable EGFR Mutation Positive Lung Cancer With Sector Sequencing for Biomarker Discovery
National Cancer Centre, Singapore
NCT03128008 COMPLETED Locally Advanced NSCLC Hyperfractionated RT
Duke University
NCT02646020 COMPLETED Aprepitant vs. Desloratadine in EGFR-TKIs Related Pruritus Treatment
Sun Yat-sen University
NCT04464967 WITHDRAWN Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers
NKGen Biotech, Inc.
NCT02574078 COMPLETED A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC)
Bristol-Myers Squibb
NCT03394118 COMPLETED TAGRISSO (Osimertinib) in NSCLC Patients in Whom T790 Mutations Are Detected by Liquid Biopsy
Asan Medical Center
NCT03595644 COMPLETED Maintenance Targeted Therapy With or Without Stereotactic Body Radiation Therapy for Stage IV Non-small Cell Lung Cancer
Tongji Hospital
NCT03644823 TERMINATED Combinatory ImmunoTherapy-1 (Com-IT-1) Irradiation and PD-1 Blockade in Locally Advanced / Advanced NSCLC
Oslo University Hospital
NCT01066234 COMPLETED Adjuvant CCRT vs CT in Minimal N2 NSCLC
Samsung Medical Center
NCT03736837 COMPLETED Study of Anlotinib Combined With Icotinib as the First-line Treatment in Patients With EGFR Mutation-positive NSCLC
Tianjin Medical University Cancer Institute and Hospital
NCT02132598 TERMINATED Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases
Liza Villaruz, MD
NCT03157089 COMPLETED Testing Afatinib in Combination With Pembrolizumab in Patients With Squamous Cell Carcinoma of the Lung
Boehringer Ingelheim
NCT03696212 TERMINATED Grapiprant (ARY-007) and Pembrolizumab in Patients With Advanced or Metastatic Post-PD-1/L1 NSCLC Adenocarcinoma
Arrys Therapeutics
NCT04267237 WITHDRAWN A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung Cancer
Hoffmann-La Roche
NCT02283749 COMPLETED BrUOG L301 With Non-Small Cell Lung Cancer and Bone Metastases
Angela Taber MD
NCT02485652 TERMINATED Phase II Trial of HM61713 for the Treatment of ≥2nd Line T790M Mutation Positive Adenocarcinoma of the Lung
Hanmi Pharmaceutical Company Limited
NCT03382899 TERMINATED Study of Pegilodecakin (LY3500518) With Pembrolizumab Compared to Pembrolizumab Alone First-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer
Eli Lilly and Company
NCT04170959 TERMINATED The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC
ethisch.comite@uza.be
NCT02574598 COMPLETED MK-3475 in Combination With Docetaxel vs Docetaxel Alone in Non-Small Cell Lung Cancer Patients
Instituto Nacional de Cancerologia de Mexico
NCT02308020 COMPLETED A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain
Eli Lilly and Company
NCT04670107 COMPLETED The Combination of Anlotinib and Immune Checkpoint Inhibitors for Advanced NSCLC Patients With Muti-line Therapy
The Affiliated Hospital of Qingdao University
NCT04576208 WITHDRAWN A Study to Evaluate the Impact of Management Strategies on Gastrointestinal-Related Adverse Events in Participants With Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations Receiving TAK-788
Takeda
NCT02443337 TERMINATED A Study of LY3023414 and Necitumumab in Squamous Lung Cancer
Eli Lilly and Company
NCT03361319 WITHDRAWN Combination Nab-paclitaxel (N-P) and Nintedanib or N-P and Placebo in Relapsed NSCLC Adenocarcinoma
Royal Marsden NHS Foundation Trust
NCT02730247 COMPLETED Clinical Trial of the Safety and Efficacy of the Addition of Ramucirumab to Nab-paclitaxel in Previously Treated Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
Liza Villaruz, MD
NCT02392507 COMPLETED A Study of Nab-Paclitaxel and Carboplatin Plus Necitumumab (LY3012211) in Participants With Stage IV Squamous NSCLC
Eli Lilly and Company
NCT04044170 TERMINATED Poziotinib in Patients With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
Hanmi Pharmaceutical Company Limited
NCT04262375 WITHDRAWN A Phase 2 Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Multi-Cancer Populations With Correlation to Clinical, Molecular and Immunologic Parameters With DNA MethylaTION
University Health Network, Toronto
NCT04262388 WITHDRAWN A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation
University Health Network, Toronto
NCT02109653 WITHDRAWN Efficacy and Safety of LGX818 in Patients With Advanced or Metastatic BRAF V600 Mutant NSCLC
Array Biopharma, now a wholly owned subsidiary of Pfizer
NCT03699033 WITHDRAWN Hypofractionated Radiotherapy With Carboplatin and Paclitaxel in Non-Small Cell Lung Cancer
Stephanie Smiddy
NCT03302247 TERMINATED Depletion of Myeloid Derived Suppressor Cells to Enhance Anti PD-1 Therapy
Fox Chase Cancer Center
NCT03724253 TERMINATED [68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR)
Advanced Accelerator Applications
NCT02642939 TERMINATED Study of Oral Mifepristone as Salvage Therapy in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
Check, Jerome H., M.D., Ph.D.
NCT03945227 WITHDRAWN Clinical Trial for Evaluating Efficacy and Safety of PDR001 in Concurrent Plus Consolidation Versus Consolidation Only in Addition to Standard Chemoradiotherapy in Unresectable Stage III NSCLC Patients (PASTURE)
Yonsei University
NCT02879760 COMPLETED Oncolytic MG1-MAGEA3 With Ad-MAGEA3 Vaccine in Combination With Pembrolizumab for Non-Small Cell Lung Cancer Patients
Turnstone Biologics, Corp.
NCT03382912 TERMINATED Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer
Eli Lilly and Company
NCT03628144 WITHDRAWN Immunonutrition to Reduce Toxicities in Non-Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
NCT03086733 COMPLETED Phase II Lung Metcore - Preoperative Metformin for Lung Cancer
University Health Network, Toronto
NCT02492568 COMPLETED Pembrolizumab After SBRT Versus Pembrolizumab Alone in Advanced NSCLC
The Netherlands Cancer Institute
NCT02490696 COMPLETED Comparative Study of the Hypoxia Measured in FAZA and F-miso PET/CT Scan in Patients With Non-small Cell Lung Cancer
Centre Henri Becquerel
NCT02412371 TERMINATED A Study Evaluating the Efficacy and Tolerability of Veliparib in Combination With Paclitaxel/Carboplatin-Based Chemoradiotherapy Followed by Veliparib and Paclitaxel/Carboplatin Consolidation in Adults With Stage III Non-Small Cell Lung Cancer (NSCLC)
AbbVie
NCT02193152 TERMINATED Pazopanib in Molecularly Selected Patients With Advanced NSCLC
Washington University School of Medicine
NCT02382796 COMPLETED A Rollover Protocol of Dacomitinib For Patients In Japan
Pfizer
NCT02831491 WITHDRAWN A Study of Ramucirumab (LY3009806) in Combination With Weekly Docetaxel in Participants With Stage IV Non-Small Cell Lung Cancer
Eli Lilly and Company
NCT03411473 TERMINATED Study of AGEN1884 With Pembrolizumab in 1L NSCLC
Agenus Inc.
NCT03472053 COMPLETED A Study of BIO-11006 in the Treatment of Advanced Non-Small Cell Lung Cancer
BioMarck Pharmaceuticals, Ltd.
NCT02848651 COMPLETED A Study of Atezolizumab as First-line Monotherapy for Advanced or Metastatic Non-Small Cell Lung Cancer
Genentech, Inc.
NCT04338867 COMPLETED Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients
Instituto Nacional de Cancerologia de Mexico
NCT02336451 COMPLETED A Phase II Study to Evaluate the Efficacy and Safety of Oral Ceritinib in Patients With ALK-positive NSCLC Metastatic to the Brain and/or to Leptomeninges
Novartis Pharmaceuticals
NCT03499834 COMPLETED A Study to Evaluate the Safety and Efficacy of Ex Vivo Expanded Autologous Immune Killer Cells (IKC) in Stage IV Non-small Cell Lung Cancer (NSCLC) in Patients Who Failed Chemotherapy or Target Therapy
Ivy Life Sciences, Co., Ltd
NCT02573506 COMPLETED Study of Split-course Chemoradiotherapy For Locally Advanced None-small Cell Lung Cancer
Sun Yat-sen University
NCT02452424 TERMINATED A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors
Daiichi Sankyo
NCT02544633 COMPLETED Phase 2 Study of MGCD265 in Patients With Non-Small Cell Lung Cancer With Activating Genetic Alterations in MET
Mirati Therapeutics Inc.
NCT03652857 COMPLETED Apatinib Combined With Vinorelbine for Non-driver Gene Mutation Non-small Cell Lung Cancer
Yongchang Zhang
NCT02469701 TERMINATED Advanced Non-Small Cell Lung Cancer Progressing After at Least One Prior Therapy For Metastatic Disease
howard safran
NCT03155009 COMPLETED A Study of the Efficacy and Safety of Alectinib in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer
Hoffmann-La Roche
NCT03129256 COMPLETED An Exploration of Apatinib Combined With S-1 in Patients With Advanced Non-small Cell Lung Cancer
Changzhou Cancer Hospital of Soochow University
NCT03232892 TERMINATED Trametinib in Patients With Advanced Neurofibromatosis Type 1 (NF1)-Mutant Non-small Cell Lung Cancer
University of California, San Francisco
NCT02770014 TERMINATED Rapid Plasma Genotyping For Early Initiation Of Erlotinib In EGFR Mutant Lung Cancer
Dana-Farber Cancer Institute
NCT03023423 COMPLETED A Study of Daratumumab in Combination With Atezolizumab Compared With Atezolizumab Alone in Participants With Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer
Janssen Research & Development, LLC
NCT02976116 COMPLETED A Phase II Study of Fruquintinib in Combination With Gefitinib in Patients With Advanced Non-small Cell Lung Cancer
Hutchison Medipharma Limited
NCT02538432 WITHDRAWN Phase II Trial of EP4 Receptor Antagonist, AAT-007 (RQ-07; CJ-023,423) in Advanced Solid Tumors
University of Maryland, Baltimore
NCT03311672 WITHDRAWN T-Cell PET Imaging With [18F]F-AraG in Lung Cancer
University of California, San Francisco
NCT02920450 TERMINATED Study of Paclitaxel, Carboplatin, and PF-05212384 in Advanced or Metastatic NSCLC (UF-STO-LUNG-002)
University of Florida
NCT02941601 WITHDRAWN A Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
Eli Lilly and Company
NCT02843815 COMPLETED Combination of Cryosurgery and NK Immunotherapy for Advanced Non-Small Cell Lung Cancer
Fuda Cancer Hospital, Guangzhou
NCT02845856 COMPLETED Combination of Cetuximab and NK Immunotherapy for Recurrent Non-small Cell Lung Cancer
Fuda Cancer Hospital, Guangzhou
NCT02448303 COMPLETED Pembrolizumab Alone and In Combination With Acalabrutinib (ACP-196) in Subjects With Advanced Non-small Cell Lung Cancer
Acerta Pharma BV
NCT03007875 COMPLETED High-activity Natural Killer Immunotherapy for Small Metastases of Non-small Cell Lung Cancer
Fuda Cancer Hospital, Guangzhou
NCT03228277 COMPLETED Olmutinib Trial in T790M (+) NSCLC Patients Detected by Liquid Biopsy Using BALF Extracellular Vesicular DNA
Konkuk University Medical Center
NCT02630186 TERMINATED A Phase 1b/2 Study of Safety and Efficacy of Rociletinib in Combination With MPDL3280A in Patients With Advanced or Metastatic EGFR-mutant NSCLC
Clovis Oncology, Inc.
NCT03121417 WITHDRAWN Nivolumab in Treating Patients With Advanced Metastatic Non-small Cell Lung Cancer
Emory University
NCT03419559 WITHDRAWN Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) In Combo With Durvalumab in Non-Small Cell Lung Cancer
Iovance Biotherapeutics, Inc.
NCT02542930 WITHDRAWN Abscopal Effect for Metastatic Non-small Cell Lung Cancer.
Zhejiang Provincial People's Hospital
NCT02846792 TERMINATED Nivolumab and Plinabulin in Treating Patients With Stage IIIB-IV, Recurrent, or Metastatic Non-small Cell Lung Cancer
University of Washington
NCT02599194 COMPLETED 18F-FSPG PET/CT for Cancer Patients on Therapy
Andrei Iagaru
NCT02403271 COMPLETED A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors
Pharmacyclics LLC.
NCT02353741 TERMINATED Concurrent EGFR-TKIs and Thoracic Radiation Therapy in Active EGFR Mutation for 1st Line Treatment of Stage IV NSCLC
Xinqiao Hospital of Chongqing
NCT02289456 COMPLETED Phase II Safety and Tolerability Trial With Nab-Paclitaxel Plus Carboplatin Followed by Nab-Paclitaxel for First Line Treatment of NSCLC Subjects With ECOG PS 2
Celgene
NCT02655913 COMPLETED Safety and Efficacy of Vitamin C Infusion in Combination With Local mEHT to Treat Non Small Cell Lung Cancer
Clifford Hospital, Guangzhou, China
NCT02669914 TERMINATED MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
Washington University School of Medicine
NCT02737709 TERMINATED Paclitaxel Detection in NSCLC Treated With TC Regimen
Sun Yat-sen University
NCT02875340 COMPLETED A Study of VAL401 in the Treatment of Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
ValiSeek Limited
NCT02623595 WITHDRAWN A Study of SBRT in Combination With rhGM-CSF for Stage IV NSCLC Patients Who Failed in Second-line Chemotherapy
Wuhan University
NCT02580708 TERMINATED Phase 1/2 Study of the Safety and Efficacy of Rociletinib in Combination With Trametinib in Patients With mEGFR-positive Advanced or Metastatic Non-small Cell Lung Cancer
Clovis Oncology, Inc.
NCT03370159 WITHDRAWN CPI-613 and Docetaxel in Treating Patients With Stage IIIB or IV Non-small Cell Lung Cancer
Wake Forest University Health Sciences
NCT02014545 WITHDRAWN Evaluation of Lucanthone to Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer
Wake Forest University Health Sciences
NCT02403895 TERMINATED AZD2014 and Weekly Paclitaxel in Squamous NSCLC
AstraZeneca
NCT02423954 TERMINATED Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)
Western Regional Medical Center
NCT03023904 WITHDRAWN Nivolumab in Treating Patients With Stage IV or Recurrent Lung Cancer With High Mutation Loads
Vanderbilt-Ingram Cancer Center
NCT02444819 COMPLETED Phase II Trial to Evaluate the Efficacy and Safety of HM61713 as the 1st-line NSCLC Anticancer Therapy
Hanmi Pharmaceutical Company Limited
NCT03353428 WITHDRAWN Intervention of Engineered Immune Effector T Cells Against Lung Cancer
Shenzhen Geno-Immune Medical Institute
NCT02393209 TERMINATED Docetaxel With or Without TAK-117 (MLN1117) in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Millennium Pharmaceuticals, Inc.
NCT02919462 TERMINATED Open-label, Multicenter, Randomized Phase II Trial of Treatment With Cisplatin and Pemetrexed or Cisplatin and Oral Vinorelbine in Chemotherapy Naïve Patients Affected by Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer With High Thymidylate Synthase Expression
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
NCT03130764 WITHDRAWN Durvalumab and Tremelimumab for Adjuvant Therapy of Resected NSCLC
Columbia University
NCT02947113 WITHDRAWN Combination of Platinum Doublets and Hypofractionated Radiotherapy in NSCLC
The Netherlands Cancer Institute
NCT02405910 WITHDRAWN Ph2 Nab-paclitaxel With Gemcitabine to Determine Efficacy in Advanced Non-squamous NSCLC.
West Virginia University
NCT02924233 WITHDRAWN Sym004 in Combination With Nivolumab Versus Nivolumab Monotherapy in EGFR-amplified Squamous Non-Small Cell Lung Cancer
Symphogen A/S
NCT02639234 WITHDRAWN Vigil™ + Nivolumab in Advanced Non-Small Cell Lung Cancer
Gradalis, Inc.
NCT03042013 WITHDRAWN A Study for Subjects Who Are Participating in an Astellas-sponsored ASP8273 Study
Astellas Pharma Global Development, Inc.
NCT02495636 WITHDRAWN Phase 2 Study of MPDL3280A Combined With CDX-1401 in NY-ESO 1 (+) IIIB, IV or Recurrent Non-Small Cell Lung Cancer
Yale University
NCT02735850 WITHDRAWN Combination of SABR and L19-IL2 in Patients With Stage IV Lung Cancer (ImmunoSABR)
Maastricht Radiation Oncology
NCT02276560 TERMINATED Cisplatin and Nab-paclitaxel for (N2) Defined NSCLC
UNC Lineberger Comprehensive Cancer Center
NCT02661100 WITHDRAWN A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously Treated Advanced Solid Tumor Patients
Case Comprehensive Cancer Center
NCT02522910 WITHDRAWN An Open-label Phase Ib/II Study of BAY 1000394 (Roniciclib) in Combination With Docetaxel in Second- or Third-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
Yonsei University
NCT02673814 WITHDRAWN Phase 2 Trial of Durvalumab With or Without Bavituximab in Patients With Previously Treated Metastatic Non-small-cell Lung Cancer
Peregrine Pharmaceuticals
NCT02705339 WITHDRAWN Rociletinib Genomic Landscape in Non-small Cell Lung Cancer (NSCLC)
Washington University School of Medicine
NCT02470065 SUSPENDED Neoadjuvant Afatinib in Early Stage Non Small Cell Lung Cancer.
European Organisation for Research and Treatment of Cancer - EORTC
NCT02297425 WITHDRAWN A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer
Pfizer