TheraRadar

Pharma Intelligence, Simplified

Landscape Oncology

Head and Neck Cancer

939 clinical trials

524 active
/
939 total (since 2015)
231
Phase 1 Active
459 total
335
Phase 2 Active
560 total
50
Phase 3 Active
77 total
6
Phase 4 Active
19 total

Top Sponsors (Industry)

Sorted by active Active Done Failed
Sichuan Baili Pharmaceutical Co., Ltd. 9 0 0
AstraZeneca 6 4 0
Pfizer 4 2 9
Rakuten Medical, Inc. 4 1 2
Seagen, a wholly owned subsidiary of Pfizer 4 1 0
Merus B.V. 4 0 0
Boehringer Ingelheim 4 0 0
ALX Oncology Inc. 3 0 0
Exelixis 3 0 0
NGM Biopharmaceuticals, Inc 3 0 0
Regeneron 2 0 2
R-Pharm 2 1 0
Eli Lilly 2 0 1
Inhibrx Biosciences, Inc 2 0 1
Johnson & Johnson Enterprise Innovation Inc. 2 0 0
NCT05063552 ACTIVE NOT RECRUITING
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
National Cancer Institute (NCI) n=430
NCT06496178 RECRUITING
A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients
Merus B.V. n=500
NCT06992427 RECRUITING
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
Alliance for Clinical Trials in Oncology n=228
NCT07026474 RECRUITING
Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCC
Universität des Saarlandes n=214
NCT05721755 RECRUITING
Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck
ECOG-ACRIN Cancer Research Group n=290
NCT07441681 NOT YET RECRUITING
Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin
NRG Oncology n=454
NCT07435324 ACTIVE NOT RECRUITING
A Comparative Study of Efficacy and Safety of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma
R-Pharm n=161
NCT07432087 NOT YET RECRUITING
Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma
Yue He, MD n=246
NCT06525220 RECRUITING
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
Merus B.V. n=500
NCT06589804 RECRUITING
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
National Cancer Institute (NCI) n=158
NCT04967391 ACTIVE NOT RECRUITING
Tumescence in HNC Skin Graft Reconstruction
University of California, Davis n=58
NCT04892173 RECRUITING
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
Johnson & Johnson Enterprise Innovation Inc. n=500
NCT07276399 RECRUITING
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Janssen Research & Development, LLC n=500
NCT04534205 RECRUITING
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
BioNTech SE n=350
NCT06641791 RECRUITING
Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer
Canadian Cancer Trials Group n=196
NCT06129864 RECRUITING
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
AstraZeneca n=1,145
NCT06788990 RECRUITING
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Bicara Therapeutics n=650
NCT05815927 RECRUITING
Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer
European Organisation for Research and Treatment of Cancer - EORTC n=200
NCT07371897 NOT YET RECRUITING
Toripalimab ± Chemo as Neoadjuvant Therapy in LA-HNSCC: A Phase III Trial
Sun Yat-sen University n=154
NCT07320690 NOT YET RECRUITING
De-Escalation Surgery After Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University n=356
NCT04590963 ACTIVE NOT RECRUITING
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
AstraZeneca n=370
NCT06790966 ACTIVE NOT RECRUITING
Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
PDS Biotechnology Corp. n=351
NCT06851663 RECRUITING
Trop2-targeted immunoPET Imaging of Solid Tumors
RenJi Hospital n=400
NCT06295731 RECRUITING
INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC
Inhibrx Biosciences, Inc n=410
NCT06699212 RECRUITING
A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases
Rakuten Medical, Inc. n=412
NCT05273307 RECRUITING
Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy
University of California, San Francisco n=40
NCT03340896 ACTIVE NOT RECRUITING
Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RT
Groupe Oncologie Radiotherapie Tete et Cou n=256
NCT04966481 RECRUITING
Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor
Washington University School of Medicine n=81
NCT06082167 ACTIVE NOT RECRUITING
Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Exelixis n=600
NCT06492460 RECRUITING
2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma
Sun Yat-sen University n=422
NCT05078047 RECRUITING
Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO
UNICANCER n=646
NCT04178174 RECRUITING
Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
Centre hospitalier de l'Université de Montréal (CHUM) n=360
NCT02998385 ACTIVE NOT RECRUITING
Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
Groupe Oncologie Radiotherapie Tete et Cou n=342
NCT02999087 ACTIVE NOT RECRUITING
Randomized Trial of Avelumab-cetuximab-radiotherapy Versus SOCs in LA SCCHN (REACH)
Groupe Oncologie Radiotherapie Tete et Cou n=707
NCT03576417 ACTIVE NOT RECRUITING
A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and Neck
Groupe Oncologie Radiotherapie Tete et Cou n=680
NCT06064877 RECRUITING
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
AVEO Pharmaceuticals, Inc. n=410
NCT03769506 ACTIVE NOT RECRUITING
ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy
Rakuten Medical, Inc. n=135
NCT06772428 NOT YET RECRUITING
Nano-crystalline Megestrol Acetate for Adjuvant Treatment in High-risk Head and Neck Squamous Cell Carcinoma After Surgery.
Changchun GeneScience Pharmaceutical Co., Ltd. n=96
NCT06719479 NOT YET RECRUITING
A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.).
SUNHO(China)BioPharmaceutical CO., Ltd. n=60
NCT06601335 RECRUITING
A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)
Akeso n=510
NCT04747054 RECRUITING
Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed Metastatic Head & Neck Cancers
UNICANCER n=102
NCT06647563 NOT YET RECRUITING
Neoadjuvant Toripalimab + Chemotherapy ± Cetuximab in Locally Advanced Head and Neck Squamous Cell Carcinoma (Neo-ICT)
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University n=355
NCT06248996 RECRUITING
a Multicentre Phase III Study of Risk-based Treatment Intensification With Hyperfractionated Radiotherapy in Head and Neck Cancer Patients
Lund University Hospital n=308
NCT03755739 RECRUITING
Trans-Artery/Intra-Tumor Infusion of Checkpoint Inhibitors Plus Chemodrug for Immunotherapy of Advanced Solid Tumors
Second Affiliated Hospital of Guangzhou Medical University n=200
NCT05582265 RECRUITING
Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Head and Neck Squamous Cell Carcinoma (REDUCTION-I)
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University n=537
NCT03519048 ACTIVE NOT RECRUITING
Multicentric Comparative Study Between a Conventional and an Intensive Follow up Strategy After Treatment of a Head and Neck Squamous Cell Carcinoma
Gustave Roussy, Cancer Campus, Grand Paris n=197
NCT06327139 RECRUITING
Optimising Patient Experience in Head and Neck Radiotherapy
Irish Research Radiation Oncology Group n=201
NCT06102395 RECRUITING
Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCC
Beijing Tongren Hospital n=272
NCT05980715 RECRUITING
PD-1 Inhibitor Therapy Versus Radiotherapy in pCR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University n=324
NCT05044117 RECRUITING
Single-agent Capecitabine as Metronomic Chemotherapy in LAHNSCC (CMHN)
Sun Yat-sen University n=220
NCT05050162 SUSPENDED
Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer
NRG Oncology n=1,714
NCT05386550 TERMINATED
Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)
EMD Serono Research & Development Institute, Inc. n=166
NCT03258554 COMPLETED
Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin
National Cancer Institute (NCI) n=196
NCT04157985 COMPLETED
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Dan Zandberg n=161
NCT03358472 COMPLETED
Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304)
Incyte Corporation n=89
NCT04338399 COMPLETED
The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC
Adlai Nortye Biopharma Co., Ltd. n=487
NCT04459715 TERMINATED
A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
EMD Serono Research & Development Institute, Inc. n=730
NCT02358031 COMPLETED
A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048)
Merck Sharp & Dohme LLC n=882
NCT05930938 TERMINATED
Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer
Groupe Oncologie Radiotherapie Tete et Cou n=19
NCT04199104 COMPLETED
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010)
Merck Sharp & Dohme LLC n=511
NCT05523323 COMPLETED
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension
Merck Sharp & Dohme LLC n=112
NCT05369234 COMPLETED
Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
Covenant Health Cancer Center n=100
NCT03452137 TERMINATED
A Study of Atezolizumab (Anti-PD-L1 Antibody) as Adjuvant Therapy After Definitive Local Therapy in Patients With High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Hoffmann-La Roche n=406
NCT02741570 COMPLETED
Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Bristol-Myers Squibb n=947
NCT05364918 COMPLETED
Clinical Study On Acute Radiotherapy-Induced Oral Mucositis In Patients With Locally Advanced Head And Neck Tumors
Affiliated Cancer Hospital & Institute of Guangzhou Medical University n=100
NCT05802290 COMPLETED
NIVolumab in Subjects With Recurrent or Metastatic Platinum-refrACTORy SCCHN
Gruppo Oncologico del Nord-Ovest n=124
NCT04969861 TERMINATED
BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)
Nektar Therapeutics n=1
NCT02997553 COMPLETED
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery
Institut de Cancérologie de Lorraine n=744
NCT04129320 WITHDRAWN
Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and Neck
MacroGenics
NCT02551159 COMPLETED
Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer
AstraZeneca n=823
NCT02952586 TERMINATED
Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)
Pfizer n=697
NCT03349710 COMPLETED
Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer
Bristol-Myers Squibb n=74
NCT02369874 COMPLETED
Study of MEDI4736 Monotherapy and in Combination With Tremelimumab Versus Standard of Care Therapy in Patients With Head and Neck Cancer
AstraZeneca n=736
NCT03342352 WITHDRAWN
Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)
Incyte Corporation
NCT02715596 COMPLETED
Changes in Body Composition After EPA Supplementation in Head and Neck Patients
Institut Català d'Oncologia n=54
NCT03386838 WITHDRAWN
An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck
Bristol-Myers Squibb
NCT03637335 TERMINATED
Comparing Palliative Radiotherapy With or Without Carboplatin
Institut Cancerologie de l'Ouest n=26