NCT07147231 NOT YET RECRUITING Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461) in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer
National Cancer Institute (NCI)
NCT04895722 ACTIVE NOT RECRUITING Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)
Merck Sharp & Dohme LLC
NCT06149481 RECRUITING Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)
National Cancer Institute (NCI)
NCT06324357 RECRUITING Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Boehringer Ingelheim
NCT02465060 ACTIVE NOT RECRUITING Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
National Cancer Institute (NCI)
NCT05672524 RECRUITING A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
Memorial Sloan Kettering Cancer Center
NCT07446322 NOT YET RECRUITING FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer
Oncolytics Biotech
NCT07448077 NOT YET RECRUITING Short-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC
Hebei Medical University Fourth Hospital
NCT07448142 RECRUITING Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer
Sun Yat-sen University
NCT05846867 ACTIVE NOT RECRUITING A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer
Akeso
NCT05419011 ACTIVE NOT RECRUITING Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome
National Cancer Institute (NCI)
NCT04929028 RECRUITING Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
National Cancer Institute (NCI)
NCT02888743 ACTIVE NOT RECRUITING Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer
National Cancer Institute (NCI)
NCT04751370 ACTIVE NOT RECRUITING Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer
National Cancer Institute (NCI)
NCT05078866 ACTIVE NOT RECRUITING Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
National Cancer Institute (NCI)
NCT07446387 NOT YET RECRUITING A Clinical Study of Iparomlimab and Tuvonralimab Combined With Bevacizumab and Alternating Triweekly CAPOX/mCAPIRI Regimen as First-line Treatment for Unresectable Advanced Colorectal Cancer
Jiangsu Cancer Institute & Hospital
NCT07446270 NOT YET RECRUITING Efficacy of Tunlametinib in Combination With Anti-EGFR Monoclonal Antibody in Patients With RAS-Mutated Advanced Gastrointestinal Malignancies
Chinese PLA General Hospital
NCT06657222 RECRUITING First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
Tubulis GmbH
NCT07314294 RECRUITING Phase II Study of EMB-01 in Recurrent/Metastatic Colorectal Cancer Patients
Shanghai EpimAb Biotherapeutics Co., Ltd.
NCT07447050 RECRUITING Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
University of California, Irvine
NCT02965703 ACTIVE NOT RECRUITING Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma
National Cancer Institute (NCI)
NCT06787183 RECRUITING SCRT(Short Course Radiotherapy) Combined With CAPOX Plus QL1706 for Rectal Cancer Liver Metastases
Fujian Cancer Hospital
NCT07277322 NOT YET RECRUITING Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases
Dan Feng
NCT07262619 RECRUITING EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Eikon Therapeutics
NCT07441369 ENROLLING BY INVITATION Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer
Fudan University
NCT04068610 ACTIVE NOT RECRUITING COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
MedImmune LLC
NCT04771520 RECRUITING Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors
M.D. Anderson Cancer Center
NCT06047379 RECRUITING Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Neonc Technologies, Inc.
NCT07435584 NOT YET RECRUITING Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE)
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT07435038 NOT YET RECRUITING Study of BPI-572070 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Betta Pharmaceuticals Co., Ltd.
NCT07136077 RECRUITING A Phase 2 Trial of Fruquintinib and Tislelizumab in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant Chemotherapy
M.D. Anderson Cancer Center
NCT06305247 RECRUITING A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours
Ipsen
NCT07176182 NOT YET RECRUITING Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression
Sixth Affiliated Hospital, Sun Yat-sen University
NCT06607458 RECRUITING Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
Delcath Systems Inc.
NCT07433673 RECRUITING Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
Columbia University
NCT07432399 RECRUITING Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study)
Institute of Oncology Ljubljana
NCT04895709 RECRUITING A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors
Bristol-Myers Squibb
NCT06695845 RECRUITING A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Jazz Pharmaceuticals
NCT07433283 RECRUITING Carbon Nanoparticle-Loaded Iron in the Treatment of Advanced Solid Tumor
Sichuan Enray Pharmaceutical Sciences Company
NCT07432633 RECRUITING [18F]FPyQCP PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications
Blue Earth Diagnostics
NCT07411599 NOT YET RECRUITING Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")
M.D. Anderson Cancer Center
NCT05286814 RECRUITING PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
National Cancer Institute (NCI)
NCT04851119 RECRUITING Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Children's Oncology Group
NCT04430738 ACTIVE NOT RECRUITING Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
Seagen, a wholly owned subsidiary of Pfizer
NCT06356597 ACTIVE NOT RECRUITING Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial
Jing-yuan Fang, MD, Ph. D
NCT05969860 RECRUITING At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Mayo Clinic
NCT05677113 ACTIVE NOT RECRUITING A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
Sunnybrook Health Sciences Centre
NCT06051695 RECRUITING A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
A2 Biotherapeutics Inc.
NCT07409844 NOT YET RECRUITING Neoadjuvant Immunotherapy and Organ-sparing Treatment in Patients With Stage I-III dMMR Colon Cancer
Ismail Gögenur
NCT07292298 RECRUITING Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
University of Colorado, Denver
NCT05343013 RECRUITING TAS-102 With or Without Celecoxib in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant Chemotherapy
M.D. Anderson Cancer Center
NCT07223047 RECRUITING A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
Bristol-Myers Squibb
NCT04644068 ACTIVE NOT RECRUITING Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
AstraZeneca
NCT04868877 ACTIVE NOT RECRUITING Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
Merus B.V.
NCT07020221 RECRUITING A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Verastem, Inc.
NCT07281716 RECRUITING Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC
Dan Feng
NCT06445062 RECRUITING Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Revolution Medicines, Inc.
NCT07410676 RECRUITING EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors
Essen Biotech
NCT07410494 RECRUITING Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors
Essen Biotech
NCT07023289 RECRUITING A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
AbbVie
NCT07030257 RECRUITING Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
Tasca Therapeutics
NCT06130280 RECRUITING A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT07337876 RECRUITING Organ Preservation in Rectal Cancer by Dose Escalated MR Guided Adaptive Radiotherapy
University Hospital Tuebingen
NCT06669572 RECRUITING Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment
University of Chicago
NCT05358249 ACTIVE NOT RECRUITING Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals
NCT07407465 RECRUITING Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.
Gruppo Oncologico del Nord-Ovest
NCT07145255 RECRUITING Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors
MBrace Therapeutics
NCT04432597 ACTIVE NOT RECRUITING HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers
National Cancer Institute (NCI)
NCT03654131 ACTIVE NOT RECRUITING Microwave Ablation Versus Stereotactic Body Radiotherapy for Colorectal Liver Metastases in Oligometastatic Disease: a Prospective, Randomised, Phase 2 Trial
Rigshospitalet, Denmark
NCT07405736 NOT YET RECRUITING Lubiprostone Combined With Maintenance Therapy for Prevention of Postoperative Recurrence in Peritoneal Metastatic Colorectal Cancer
Sun Yat-sen University
NCT06830239 RECRUITING Phase II Study of Neoadjuvant Dostarlimab in Patients With Untreated T3-4N0-2 or Stage III pMMR/MSS Resectable Colon Cancer
Universitaire Ziekenhuizen KU Leuven
NCT04486378 RECRUITING A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
BioNTech SE
NCT05673772 ACTIVE NOT RECRUITING Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer
Kyungpook National University Hospital
NCT07407647 RECRUITING Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer
Ohio State University Comprehensive Cancer Center
NCT07405476 NOT YET RECRUITING Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment
Emory University
NCT07397442 NOT YET RECRUITING Short-Course Radiotherapy Combined With Chemotherapy and Immunotherapy in Mid-Low Locally Advanced Rectal Cancer
Beijing Friendship Hospital
NCT07402486 NOT YET RECRUITING A Phase II Prospective Study of Maastro Applicator Brachytherapy for Rectal Cancer
Siriraj Hospital
NCT03516708 RECRUITING Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
Washington University School of Medicine
NCT06558773 RECRUITING GSL Synthetase Inhibitor Plus Immune Checkpoint Inhibitor and/or Regorafenib in Previously Treated pMMR/MSS CRC.
Chinese PLA General Hospital
NCT06244771 RECRUITING A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Frontier Medicines Corporation
NCT07403877 NOT YET RECRUITING Neoadjuvant Immunotherapy ± Radiotherapy in MSI-H/dMMR Locally Advanced Colorectal Cancer
Fudan University
NCT06369259 RECRUITING Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer
M.D. Anderson Cancer Center
NCT04585750 RECRUITING The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
PMV Pharmaceuticals, Inc
NCT04930432 RECRUITING Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors
Betta Pharmaceuticals Co., Ltd.
NCT07353645 RECRUITING KRAS Neoantigen Nanovaccine as Adjuvant Therapy for Colorectal Cancer/Pancreatic Cancer
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
NCT05919264 RECRUITING FOG-001 in Locally Advanced or Metastatic Solid Tumors
Parabilis Medicines, Inc.
NCT06128551 RECRUITING Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Revolution Medicines, Inc.
NCT04963283 ACTIVE NOT RECRUITING Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
University of Colorado, Denver
NCT07397338 RECRUITING Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors
Revolution Medicines, Inc.
NCT03851614 ACTIVE NOT RECRUITING Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors
University Health Network, Toronto
NCT07398326 RECRUITING Anlotinib Combined With Sintilimab as First-line Treatment for Advanced Non-liver Metastatic Colorectal Cancer
Shanghai Changzheng Hospital
NCT06728072 RECRUITING Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer
Virginia Commonwealth University
NCT07395063 NOT YET RECRUITING A Clinical Study on the Treatment of Metastatic Colorectal Cancer at the Second-line or Beyond.
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
NCT07227636 RECRUITING A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
Memorial Sloan Kettering Cancer Center
NCT07391566 NOT YET RECRUITING LPM6690176 in Combination With Chemotherapy and Bevacizumab in Metastatic Colorectal Cancer Patients With RAS Mutation
Luye Pharma Group Ltd.
NCT07391618 RECRUITING Clinical Study on the First-line Treatment of Advanced Colorectal Cancer With Simultaneous Infusion of Levozolinate for Injection and 5-FU
Chinese PLA General Hospital
NCT07394192 NOT YET RECRUITING Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS Stage II-III Rectal Cancer
Peking University Cancer Hospital & Institute
NCT06268015 ACTIVE NOT RECRUITING Botensilimab and Balstilimab Optimization in Colorectal Cancer
Nicholas DeVito, MD
NCT06617858 RECRUITING Trial of AMB-05X for Patients With ctDNA(+) Colorectal Cancer After Curative-intent Treatment
M.D. Anderson Cancer Center
NCT04587128 ACTIVE NOT RECRUITING Early-Line Anti-EGFR Therapy to Facilitate Retreatment for Select Patients With mCRC
University of Wisconsin, Madison
NCT06923787 RECRUITING Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study
Institute of Oncology Ljubljana
NCT05665361 RECRUITING Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)
National Cancer Institute (NCI)
NCT05217446 ACTIVE NOT RECRUITING A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
Pfizer
NCT07224022 NOT YET RECRUITING Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer
John Strickler, M.D.
NCT07201519 RECRUITING Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy
Michael J Cavnar, MD
NCT07235293 RECRUITING A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.
Kahr Bio Australia Pty Ltd
NCT07381400 NOT YET RECRUITING Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Study)
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
NCT07381764 NOT YET RECRUITING ROMANCE: "Irinotecan Plus Cetuximab Rechallenge Versus Trifluridine/Tipiracil Plus Bevacizumab in Molecularly Selected Metastatic Colorectal Cancer"
Gruppo Oncologico Italia Meridionale
NCT07381309 NOT YET RECRUITING Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM
Jun Huang
NCT07381777 NOT YET RECRUITING XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients
Gruppo Oncologico Italiano di Ricerca Clinica
NCT06710847 ACTIVE NOT RECRUITING A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
GlaxoSmithKline
NCT04787341 ACTIVE NOT RECRUITING PAnitumumab REchallenge Followed by REgorafenib Versus the Reverse Sequence
Gruppo Oncologico del Nord-Ovest
NCT04083599 ACTIVE NOT RECRUITING GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
Genmab
NCT06553885 RECRUITING Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC
H. Lee Moffitt Cancer Center and Research Institute
NCT06055439 RECRUITING A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy
Chimeric Therapeutics
NCT07148128 RECRUITING Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.
Auricula Biosciences Inc.
NCT07151040 RECRUITING Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors
One-carbon Therapeutics AB
NCT05672316 ACTIVE NOT RECRUITING Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy
City of Hope Medical Center
NCT07371273 RECRUITING Comparative Study on the Short- and Long-term Efficacy of Q-ISR, Traditional Sub-ISR, and t-ISR
Fudan University
NCT06281405 RECRUITING CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer
Fudan University
NCT04643366 RECRUITING Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer
Virginia Commonwealth University
NCT03947385 RECRUITING Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
IDEAYA Biosciences
NCT04421820 RECRUITING BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours
Bold Therapeutics, Inc.
NCT07365592 NOT YET RECRUITING Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRC
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT07358585 NOT YET RECRUITING A Phase Ib/II Study to Evaluate HLX43 Combined With HLX07 or Serplulimab in Patients With Advanced or Metastatic Colorectal Cancer
Shanghai Henlius Biotech
NCT04599140 ACTIVE NOT RECRUITING SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trial
M.D. Anderson Cancer Center
NCT07359456 NOT YET RECRUITING Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases
UNICANCER
NCT06428409 RECRUITING A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Merck Sharp & Dohme LLC
NCT05009069 ACTIVE NOT RECRUITING A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer
Hoffmann-La Roche
NCT05954429 RECRUITING A Study to Explore the Third-line Treatment of Fruquintinib Combined With Serplulimab in Advanced Non-liver-limited Metastatic Colorectal Cancer: a Single-center, Phase 2 Study
Fudan University
NCT06948448 RECRUITING A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
Ono Pharmaceutical Co. Ltd
NCT07355764 NOT YET RECRUITING MA-CRC-II-016 SHR-1811
Peking Union Medical College Hospital
NCT05705492 RECRUITING Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer
OHSU Knight Cancer Institute
NCT07286695 NOT YET RECRUITING Fruquintinib Combined With Trifluridine/Tipiracil Versus Bevacizumab Combined With Trifluridine/Tipiracil for Advanced Metastatic Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT04767984 ACTIVE NOT RECRUITING Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis
Northwestern University
NCT04482309 RECRUITING A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors
AstraZeneca
NCT03539822 RECRUITING Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies
Anwaar Saeed
NCT07357220 NOT YET RECRUITING A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases
Akeso
NCT07005570 RECRUITING Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer (SPARK)
Dechang Diao
NCT07209215 NOT YET RECRUITING ctDNA-Informed Management of Early-Stage Rectal Cancer
University of California, Davis
NCT07353268 NOT YET RECRUITING Phase Ib/II Study of QL1706 + Fruquintinib + SCRT vs. Standard Third-Line Therapy in Unresectable Liver-Metastatic pMMR/MSS Colorectal Cancer: Safety, Tolerability, and Efficacy.
Tao Zhang
NCT06792695 RECRUITING A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
AstraZeneca
NCT05726864 ACTIVE NOT RECRUITING A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors
Elicio Therapeutics
NCT05379595 RECRUITING A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
Janssen Research & Development, LLC
NCT07347951 RECRUITING A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer
First Affiliated Hospital of Wenzhou Medical University
NCT06710756 RECRUITING Lead-212 PSV359 Therapy for Patients With Solid Tumors
Perspective Therapeutics
NCT02584244 RECRUITING Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
Lumicell, Inc.
NCT07042685 RECRUITING Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer
The Methodist Hospital Research Institute
NCT06589440 RECRUITING Phase 2 Study of SR-8541A in Combination With Botensilimab and Balstilimab in Subjects With Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC)
Stingray Therapeutics
NCT07189871 RECRUITING 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
Radiopharm Theranostics, Ltd
NCT07341737 NOT YET RECRUITING SL-28 for Advanced Solid Tumours
Second Life Therapeutics
NCT06129604 ACTIVE NOT RECRUITING Pilot Window of Opportunity Trial (POET)
University of Oklahoma
NCT06864013 RECRUITING SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer
First Affiliated Hospital of Zhejiang University
NCT03228667 ACTIVE NOT RECRUITING QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
ImmunityBio, Inc.
NCT07337551 NOT YET RECRUITING Gossypol Acetate + FOLFIRI + Bev in mCRC With TP53-Mutant and LRPPRC Positive
Guiying Wang
NCT05651022 ACTIVE NOT RECRUITING Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors
Indaptus Therapeutics, Inc
NCT05759728 RECRUITING A Study of CNA3103 (LGR5-targeted, Autologous CAR-T Cells) Administered to Subjects With Metastatic Colorectal Cancer
Carina Biotech Limited
NCT04689347 RECRUITING 5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer.
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
NCT06106308 ACTIVE NOT RECRUITING Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation
Cardiff Oncology
NCT03087071 ACTIVE NOT RECRUITING Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer
M.D. Anderson Cancer Center
NCT03104439 ACTIVE NOT RECRUITING Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer
Massachusetts General Hospital
NCT03599752 ACTIVE NOT RECRUITING Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases
M.D. Anderson Cancer Center
NCT03844620 ACTIVE NOT RECRUITING Circulating Cell-Free Tumor DNA Testing in Guiding Treatment for Patients With Advanced or Metastatic Colorectal Cancer
M.D. Anderson Cancer Center
NCT02568267 ACTIVE NOT RECRUITING Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Hoffmann-La Roche
NCT04564898 ACTIVE NOT RECRUITING Trifluridine/Tipiracil in Combination With Capecitabine and Bevacizumab in Metastatic Colorectal Cancer Patients.
Gruppo Oncologico del Nord-Ovest
NCT07229846 NOT YET RECRUITING A Single-arm, Single-center, Phase II Clinical Study of Aipalolitovorelizumab (QL1706) Combined With Bevacizumab and Standard Chemotherapy as First-line Treatment for MSS/pMMR Metastatic Colorectal Cancer With BRAF V600E Mutation
Yanqiao Zhang
NCT06399757 RECRUITING A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors
Apollo Therapeutics Ltd
NCT05296681 RECRUITING Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery
Howard S. Hochster, MD
NCT07068763 RECRUITING Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer
Sir Run Run Shaw Hospital
NCT03921684 ACTIVE NOT RECRUITING Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients
Baruch Brenner
NCT03983993 ACTIVE NOT RECRUITING Niraparib and Panitumumab in Patients With Advanced or Metastatic Colorectal Cancer
Emory University
NCT04657068 RECRUITING A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Artios Pharma Ltd
NCT06578559 ACTIVE NOT RECRUITING Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC
Gruppo Oncologico del Nord-Ovest
NCT07314528 NOT YET RECRUITING Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer
St. James's Hospital, Ireland
NCT04556253 ACTIVE NOT RECRUITING AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer
Peking University
NCT06801665 RECRUITING FMT+ QL1706+Bevacizumab+ XELOX as First-line Treatment for Advanced MSS-type Colon Cancer With Liver Metastasis
Hua Jiang
NCT04708470 ACTIVE NOT RECRUITING A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
National Cancer Institute (NCI)
NCT07281157 RECRUITING Irinotecan Liposome Plus Capecitabine and Enronsubemab Combined With Short-course Radiotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT07279077 RECRUITING Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial
Sixth Affiliated Hospital, Sun Yat-sen University
NCT07079462 RECRUITING Comparing 68Ga-FAPI PET-Guided Abdominal Radiotherapy Combined With Second-Line Standard Therapy and Cadonilimab Versus Second-Line Standard Therapy in Colorectal Cancer With Peritoneal Metastasis
Fudan University
NCT06722183 RECRUITING Futibatinib in Combination With (Chemo)Immunotherapy in Colorectal Cancer and Other Solid Tumor Entities
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT06824064 RECRUITING Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer
Riboscience, LLC.
NCT04729322 ACTIVE NOT RECRUITING Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders
M.D. Anderson Cancer Center
NCT04616183 ACTIVE NOT RECRUITING LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer
M.D. Anderson Cancer Center
NCT07297030 NOT YET RECRUITING SIB-RT Combined With CAPOX and PD-1 for High-Risk Rectal Cancer
Sun Yat-sen University
NCT07285044 RECRUITING The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Mayo Clinic
NCT06992258 RECRUITING A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
Criterium, Inc.
NCT06540326 RECRUITING Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT07297004 RECRUITING Stereotactic Body Radiation Therapy for Unresectable Locally Recurrent Rectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University
NCT06934538 RECRUITING First-in-human Trial of STC-1010, an Immunotherapy, in Patients With Unresectable Locally Advanced or Metastatic Colorectal Cancer
Brenus Pharma
NCT07192068 RECRUITING Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.
UNICANCER
NCT07169734 RECRUITING A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Alentis Therapeutics AG
NCT07291401 NOT YET RECRUITING Radiotherapy Plus CAPOX, and Iparomlimab and Tuvonralimab (QL1706) as Neoadjuvant Therapy for LARC
Zhongnan Hospital
NCT02955940 ACTIVE NOT RECRUITING An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
Incyte Corporation
NCT05959356 RECRUITING Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer
Sun Yat-sen University
NCT07213570 RECRUITING STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer
National Cancer Institute, Naples
NCT06714357 RECRUITING ValproIc Acid to Potentiate Anti-EGFR Treatment Efficacy and Prevent/Revert Resistance in Colorectal Cancer
National Cancer Institute, Naples
NCT07284992 RECRUITING SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC
Shandong Provincial Hospital
NCT07281768 NOT YET RECRUITING Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT07283367 NOT YET RECRUITING A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients.
Hansoh BioMedical R&D Company
NCT06413680 RECRUITING A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
Regeneron Pharmaceuticals
NCT06107413 ACTIVE NOT RECRUITING Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab
AbbVie
NCT06856837 RECRUITING - IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT06245356 RECRUITING Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer
UNICANCER
NCT05843188 ACTIVE NOT RECRUITING Study of Hydroxychloroquine With FOLFIRI and Bevacizumab in DTP-high Metastatic Colorectal Cancer
University Health Network, Toronto
NCT05131919 ACTIVE NOT RECRUITING Pembrolizumab for Locally Advanced, Irresectable, Non-metastatic dMMR Colorectal Cancers
The Netherlands Cancer Institute
NCT07268677 NOT YET RECRUITING A Single-arm Clinical Study Evaluating Pirfenidone and Sintilimab in Combination With Standard Neoadjuvant Chemotherapy for Colorectal Cancer Patients With Peritoneal Metastasis.
Guoxiang Cai
NCT07255664 RECRUITING A FIH, Phase I/IIa, Trial Assessing Feasibility of Administrations of TIL-based Immunotherapy in Patients With Metastatic CRC and PC
Curacell Holding AB
NCT06731894 RECRUITING Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
City of Hope Medical Center
NCT06265285 RECRUITING Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
Mayo Clinic
NCT06205836 RECRUITING Cemiplimab With or Without Fianlimab to Treat Older Patients With Localized or Locally Advanced MSI-H Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT07261709 NOT YET RECRUITING Trifluridine/Tipiracil Plus Fruquintinib vs. Trifluridine/Tipiracil Plus Bevacizumab in Refractory Metastatic Colorectal Cancer: A Randomized, Controlled, Open-Label, Non-Inferiority Trial
Sun Yat-sen University
NCT03190941 RECRUITING Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
National Cancer Institute (NCI)
NCT07259590 RECRUITING A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation
Genfleet Therapeutics (Shanghai) Inc.
NCT06843434 RECRUITING A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma
Memorial Sloan Kettering Cancer Center
NCT07260058 NOT YET RECRUITING Immune Cell Therapy for Advanced Solid Tumors
Liaoning Medical Diagnosis and Treatment Technology Research and Development Co., Ltd.
NCT07079631 RECRUITING A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
BioNTech SE
NCT06850103 RECRUITING SCRT-CAPEOX-Serplulimab for MSS/pMMR Rectal Cancer With Oligometastases
First Affiliated Hospital of Zhejiang University
NCT06154538 RECRUITING Immune Checkpoint Inhibitors + Chemotherapy Versus Chemotherapy in the Neoadjuvant Treatment of Locally Advanced Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT07248020 NOT YET RECRUITING A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational Analysis of Tumor Tissue
Chang Gung Memorial Hospital
NCT06400160 NOT YET RECRUITING Clinical Trial of TB511 in Advanced Solid Tumors
Twinpig Biolab, Inc.
NCT07243938 NOT YET RECRUITING Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)
Tao Zhang
NCT07244705 RECRUITING A Study of ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC
Anbogen Therapeutics, Inc.
NCT06889610 RECRUITING A Phase II Clinical Study of Multimodal Ablation Combined With Systemic Drug Therapy for Advanced Solid Tumors.
Fudan University
NCT07127497 ACTIVE NOT RECRUITING Clinical Study on the Safety and Relationship of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma
The First Affiliated Hospital of Anhui Medical University
NCT04017650 ACTIVE NOT RECRUITING Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer
M.D. Anderson Cancer Center
NCT03926338 RECRUITING Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer
Sun Yat-sen University
NCT05786924 RECRUITING Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Institut de Recherches Internationales Servier
NCT07239466 NOT YET RECRUITING A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer
Tao Zhang
NCT06714292 ACTIVE NOT RECRUITING Fluorescent Approach for Refined Endoscopic Marking With Clip Localization and Identification Procedure
Seoul National University Hospital
NCT05748145 RECRUITING Metronidazole as Preoperative Therapy in CRC / FusoMetro-001
Oncology Institute of Southern Switzerland
NCT07233850 NOT YET RECRUITING A Phase II Clinical Study Evaluating SSGJ-706 in Combination Therapy for Advanced Gastrointestinal Cancers
Shenyang Sunshine Pharmaceutical Co., LTD.
NCT03997435 ACTIVE NOT RECRUITING FOLFOXIRI With or Without Intensification for Rectal Cancer
CCTU
NCT07229872 NOT YET RECRUITING A Phase II Clinical Study of Aipalolitovorelizumab (QL1706) Combined With Fruquintinib in the Treatment of Immunodominant pMMR/MSS Metastatic Colorectal Cancer That Has Failed Second-line or Above Treatment
Harbin Medical University
NCT07106892 RECRUITING Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Colorectal Cancer
Shanghai Henlius Biotech
NCT06959550 RECRUITING Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
M.D. Anderson Cancer Center
NCT05411718 RECRUITING A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome
M.D. Anderson Cancer Center
NCT05379985 RECRUITING Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Revolution Medicines, Inc.
NCT05627635 ACTIVE NOT RECRUITING FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer
City of Hope Medical Center
NCT07223424 RECRUITING Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Diwakar Davar
NCT06599502 ACTIVE NOT RECRUITING A Phase I/IIa Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD0022 as Monotherapy and in Combination With Anti-cancer Agents in Adult Participants With Tumours Harbouring a KRASG12D Mutation
AstraZeneca
NCT05200442 RECRUITING A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer
University of Chicago
NCT06349590 RECRUITING Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
University of Chicago
NCT06258525 NOT YET RECRUITING SAMe in Prevention of Oxaliplatin-associated Liver Injury
Cedars-Sinai Medical Center
NCT07011576 RECRUITING A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)
SCRI Development Innovations, LLC
NCT05205330 ACTIVE NOT RECRUITING Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI Cancers
Rottapharm Biotech
NCT05961709 RECRUITING The Phoenix Trial: Phase II Trial of Cemiplimab for the Non-operative Management of Localized dMMR Colon Cancer
M.D. Anderson Cancer Center
NCT03223779 ACTIVE NOT RECRUITING Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer
Massachusetts General Hospital
NCT05706129 RECRUITING A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
ITM Oncologics GmbH
NCT03157128 ACTIVE NOT RECRUITING A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
Eli Lilly and Company
NCT05576896 RECRUITING Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
Northwestern University
NCT05565417 ACTIVE NOT RECRUITING Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas
Immunitas Therapeutics
NCT05691491 RECRUITING Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness
National Cancer Institute (NCI)
NCT05382442 ACTIVE NOT RECRUITING A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer
Akeso
NCT07215936 ACTIVE NOT RECRUITING Dose-dense Capecitabine Schedule [7days on _7 Days Off] in Colorectal Cancer in Comparison With Standered Regimen
Sohag University
NCT03796884 ACTIVE NOT RECRUITING Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT06412198 RECRUITING A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations
M.D. Anderson Cancer Center
NCT07214142 NOT YET RECRUITING Total Neoadjuvant Therapy With PD-1 for Locally Advcancer Rectal Cancer
The First Affiliated Hospital of University of Science and Technology of China
NCT06529523 RECRUITING Tislelizumab in People With Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT07209384 NOT YET RECRUITING Clinical Efficacy of Transarterial Chemoembolization in Elderly Patients With Advanced Unresectable Colorectal Cancer
Junpeng Wang
NCT05212012 ACTIVE NOT RECRUITING D,L-MEthadone and mFOLFOX6 in Treatment of Advanced Colorectal Cancer
AIO-Studien-gGmbH
NCT06699836 RECRUITING A Phase 2 Study of Leronlimab in Combination With TAS-102 + Bevacizumab in Previously Treated Participants With mCRC
CytoDyn, Inc.
NCT06784947 ACTIVE NOT RECRUITING Trial of Atezolizumab, Bevacizumab, and Tiragolumab in Patients With Microsatellite Stable, Metastatic Colorectal Cancer
University of Colorado, Denver
NCT04705818 ACTIVE NOT RECRUITING Combining Epigenetic And Immune Therapy to Beat Cancer.
Institut Bergoni��
NCT07204574 RECRUITING The Phase 1b/IIa, Open-label, Dose Escalation and Dose Expansion to Evaluate Safety, Tolerability, and Preliminary Efficacy of the Combination of HCB101, Cetuximab/Bevacizumab, and FOLFOX/FOLFIRI in Advanced or Metastatic Colorectal Cancer
Chang Gung Memorial Hospital
NCT05609370 ACTIVE NOT RECRUITING A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer
BeiGene
NCT07202364 NOT YET RECRUITING A Study of YL202 in Patients With Advanced Solid Tumors
MediLink Therapeutics (Suzhou) Co., Ltd.
NCT07198321 NOT YET RECRUITING A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors
Genfleet Therapeutics (Shanghai) Inc.
NCT07198165 RECRUITING SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC
Ruijin Hospital
NCT04595266 ACTIVE NOT RECRUITING Chemoembolization (Lifepearls-Irinotecan) in Patients With Colorectal Cancer and Metastatic Disease
Grupo Espanol Multidisciplinario del Cancer Digestivo
NCT06820463 RECRUITING A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
AbbVie
NCT07150247 RECRUITING Safety and Efficacy of IB-FOLFIRI in BRAF V600E-Mutant Metastatic Colorectal Cancer
Sun Yat-sen University
NCT06008054 RECRUITING A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Esophageal Cancer, Gastric Cancer, Colorectal Cancer and Other Gastrointestinal Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT07140679 RECRUITING Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer
Emory University
NCT06368141 RECRUITING Neoadjuvant Chemotherapy Plus Sequential Immune Checkpoint Inhibitor (ICI) Therapy in Locally Advanced Colon Cancer
Ruijin Hospital
NCT03745326 RECRUITING Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients
National Cancer Institute (NCI)
NCT04912765 RECRUITING Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC
National Cancer Centre, Singapore
NCT02628067 ACTIVE NOT RECRUITING Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)
Merck Sharp & Dohme LLC
NCT06577194 RECRUITING A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy With IL-2 Followed by Sequential Immunotherapy With CAPOX Combined With PD-1 Antibody and IL-2 for Locally Advanced Rectal Cancer
The First Affiliated Hospital with Nanjing Medical University
NCT07183865 RECRUITING Hypofractionated Radiotherapy Combined With NALIRIF, PD-1 Antibody in Locally Recurrent Rectal Cancer(NOVELTY-R)
Fudan University
NCT03026140 RECRUITING Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer
The Netherlands Cancer Institute
NCT05308446 ACTIVE NOT RECRUITING Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation
National Cancer Institute (NCI)
NCT05694936 RECRUITING Combining Sodium Valproate With Standard-of-care EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody Treatment in Patients With Metastatic Colorectal Cancer
Australasian Gastro-Intestinal Trials Group
NCT06362369 RECRUITING A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
7 Hills Pharma, LLC
NCT07178717 NOT YET RECRUITING A Study to Characterize Encorafenib Plus Cetuximab as Rechallenge Treatment for BRAF V600E-mutant Metastatic Colorectal Cancer Patients After Previous Therapy With BRAF Inhibitors-based Combinations
Vall d'Hebron Institute of Oncology
NCT07175636 NOT YET RECRUITING QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer
Sun Yat-sen University
NCT07162714 NOT YET RECRUITING SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer
Zhejiang Cancer Hospital
NCT06682793 RECRUITING A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
A2 Biotherapeutics Inc.
NCT05610163 ACTIVE NOT RECRUITING Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation
Alliance for Clinical Trials in Oncology
NCT07150403 NOT YET RECRUITING Second-line Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Fruquintinib Versus Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Bevacizumab in Metastatic Colorectal Cancer
Federation Francophone de Cancerologie Digestive
NCT06884670 RECRUITING Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study
The First Affiliated Hospital with Nanjing Medical University
NCT05990543 ACTIVE NOT RECRUITING Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer
Korea University Anam Hospital
NCT07156682 NOT YET RECRUITING QL1706 Plus XELOX as Neoadjuvant Therapy for MSS/pMMR Clinical Stage III Colon Cancer
Qilu Hospital of Shandong University
NCT04977453 RECRUITING GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors
GI Innovation, Inc.
NCT07154316 RECRUITING Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer
Fudan University
NCT06770270 RECRUITING Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT)
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT05608044 ACTIVE NOT RECRUITING A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer
Agenus Inc.
NCT06936527 ENROLLING BY INVITATION XS-03 in Combination With FOLFOX or FOLFIRI and Bevacizumab for Treatment of Metastatic Colorectal Cancer Patients With RAS Mutation
NovaOnco Therapeutics Co., Ltd.
NCT05706779 RECRUITING Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer
Federation Francophone de Cancerologie Digestive
NCT07150949 RECRUITING Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC)
Fudan University
NCT07134101 NOT YET RECRUITING Neoadjuvant Therapy for Locally Advanced Low Rectal Cancer (SMARTi-RC01)
The First Affiliated Hospital with Nanjing Medical University
NCT05722288 RECRUITING Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers
City of Hope Medical Center
NCT05576480 RECRUITING SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer
Ruijin Hospital
NCT05451849 ACTIVE NOT RECRUITING A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
TCR2 Therapeutics
NCT05024097 RECRUITING A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
Weill Medical College of Cornell University
NCT06887218 RECRUITING 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
The Methodist Hospital Research Institute
NCT06764680 RECRUITING Oral Chemotherapy, Targeted Therapy and Immunotherapy With/Without Radiotherapy as 3rd- or Later-line Therapy for Advanced MSS/pMMR Colorectal Cancer
Sun Yat-sen University
NCT05515796 RECRUITING Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT04111172 ACTIVE NOT RECRUITING A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
Thomas Jefferson University
NCT07133750 NOT YET RECRUITING PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
Biotheus Inc.
NCT04166604 ACTIVE NOT RECRUITING LONsurf and G-CSF Use: Being On A Right Dose-intensity to Optimize Treatment Efficacy
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT06434597 RECRUITING A Clinical Study of SPH5030 Tablets in the Treatment of Her2-positive/Mutated Biliary Tract OR Colorectal Cancer Patients.
Shanghai Pharmaceuticals Holding Co., Ltd
NCT05864144 ACTIVE NOT RECRUITING A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Sensei Biotherapeutics, Inc.
NCT07124884 NOT YET RECRUITING 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab
Federation Francophone de Cancerologie Digestive
NCT07057089 RECRUITING Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Field I)
Hebei Medical University Fourth Hospital
NCT07123441 NOT YET RECRUITING A Study on the Efficacy and Safety of Irinotecan Liposome (II), 5-FU/LV in Combination With Bevacizumab for the Treatment of Advanced Colorectal Cancer
Sanjun Cai
NCT07106034 NOT YET RECRUITING Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial
Shanghai Pudong Hospital
NCT07044908 RECRUITING TQB2922 and TAS-102 Tablets for Injection With or Without Bevacizumab in Chemotherapy-failed RAS/BRAF Wild-type Advanced Colorectal Cancer
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
NCT06298916 RECRUITING 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer
Lantheus Medical Imaging
NCT07116577 NOT YET RECRUITING Radiotherapy Combined QL1706, TAS-102 and Bevacizumab in mCRC
Jinan Central Hospital
NCT05057013 ACTIVE NOT RECRUITING A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
Cancer Research UK
NCT06356714 RECRUITING Nocardia Rubra Cell Wall Skeleton in Combination With Prior Second- or Third-line Regimens for the Treatment of Potentially Hazardous Colorectal Cancer SD Status
Sun Jing
NCT07071714 RECRUITING A Phase II Study of SHR-8068 Injection in Combination With Anti-tumor Therapies in Colorectal Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT05254327 RECRUITING Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001
University of Nebraska
NCT07108127 RECRUITING Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer
Peking Union Medical College Hospital
NCT06856187 RECRUITING Second-line Standard Treatment Sequential TAS-102 and Bevacizumab Combined With Local Treatment in Advanced Colorectal Cancer
Fudan University
NCT06395519 RECRUITING A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
858 Therapeutics, Inc.
NCT03493048 ACTIVE NOT RECRUITING Cetuximab Plus FOLFOXIRI vs Cetuximab Plus FOLFOX For CRCLM
Sun Yat-sen University
NCT07025850 NOT YET RECRUITING Efficacy Study of Digoxin Combined With Serplulimab and Chemotherapy in First-Line Treatment of MSS Advanced Colorectal Cancer
Fudan University
NCT07095309 NOT YET RECRUITING Safety and Effectiveness Study of Pre-operative Artesunate in Stage II/ III Colorectal Cancer
Metanoic Health Ltd.
NCT07095439 RECRUITING Efficacy and Toxicity of Total Neoadjuvant Sandwich Treatment Via Short Course Radiotherapy in the Treatment of Stage II and III Rectal Cancer Patients
Ain Shams University
NCT06105021 ACTIVE NOT RECRUITING Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor
Affini-T Therapeutics, Inc.
NCT06605430 RECRUITING Medical Cannabis in Patients With Advanced Pancreatic and Colorectal Cancer
HealthPartners Institute
NCT07085169 RECRUITING Low-dose Trifluridine/Tipiracil With Bevacizumab in mCRC
Ruijin Hospital
NCT06846268 RECRUITING Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer
National University Hospital, Singapore
NCT06940388 RECRUITING Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer.
brenner baruch
NCT05571644 RECRUITING Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer
Sun Yat-sen University
NCT03446157 ACTIVE NOT RECRUITING Palbociclib and Cetuximab in Metastatic Colorectal Cancer
UNC Lineberger Comprehensive Cancer Center
NCT07077083 NOT YET RECRUITING CAIX PET/CT for Residual or Recurrent Post-ablative ccRCC
Massachusetts General Hospital
NCT06895031 RECRUITING Study of JYP0015 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Guangzhou JOYO Pharma Co., Ltd
NCT07071844 NOT YET RECRUITING BETWEEN: Biweekly Bevacizumab + Trifluridine/Tipiracil to Reduce Grade 3-4 Neutropenia in mCRC Patients
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT07070713 NOT YET RECRUITING Efficacy and Safety of FOLFOX+Cetuximab vs. FOLFOXIRI+Bevacizumab Both With QL1706 in First-Line Treatment of Left-Sided mCRC
Fujian Cancer Hospital
NCT06279351 RECRUITING Thalidomide Enhances Clinical Efficacy of Cetuximab Combined With Standard Chemotherapy for Left Colorectal Cancer
Xinqiao Hospital of Chongqing
NCT05489211 RECRUITING Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
AstraZeneca
NCT07059949 NOT YET RECRUITING Short Course Radiotherapy Followed by CAPOX and Carrilizumab and Bevacizumab or Cetuximab for the Initial Treatment of Unresectable Metastatic Rectal Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT06873763 RECRUITING Nelmastobart in Combination With Trifluridine/ Tipiracil and Bevacizumab in Metastatic/ Recurrent Colorectal Cancer
STCube, Inc.
NCT07061210 NOT YET RECRUITING An Explorative Study of HRS-2189 Combined With Adebrelimab and BP102 for Metastatic Colorectal Cancer
Fudan University
NCT07058012 NOT YET RECRUITING A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)
NSABP Foundation Inc
NCT03935893 RECRUITING Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
Udai Kammula
NCT07059338 NOT YET RECRUITING Dual EGFR/HER2 Blockade Combined With Irinotecan for the Treatment of HER2-Positive Metastatic Colorectal Cancer
Sun Yat-sen University
NCT05086692 RECRUITING A Beta-only IL-2 ImmunoTherapY Study
Medicenna Therapeutics, Inc.
NCT03657641 ACTIVE NOT RECRUITING Regorafenib and Pembrolizumab in Treating Participants With Advanced or Metastatic Colorectal Cancer
University of Southern California
NCT07051785 NOT YET RECRUITING Fruquintinib vs Bevacizumab Combined With Irinotecan Liposome and Capecitabine as Second-Line Therapy for Advanced Metastatic Colorectal Cancer
Liu Huang
NCT06630624 RECRUITING Dose Finding, Efficacy and Immunological Response of IP-001 Following MWA or IRE for CRLM
M.R. Meijerink
NCT07047560 RECRUITING Liposomal Irinotecan (II) Fractionated Dosing Combined With 5-FU/LV (FOLFIRInali-3) and Bevacizumab in Second-line Treatment of Advanced Colorectal Cancer: A Single-arm, Phase II Clinical Study
Tianjin Medical University Cancer Institute and Hospital
NCT07044921 RECRUITING Clinical Study of Irinotecan Liposome (II)-Based Combination Treatment for Irinotecan-resistant Colorectal Cancer.
Chinese PLA General Hospital
NCT05310643 RECRUITING Nivolumab and Ipilimumab in Anti-PD1-Resistant dMMR/MSI mCRC
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT06949111 RECRUITING Radiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer(Neo-Color)
Hebei Medical University Fourth Hospital
NCT04864067 ACTIVE NOT RECRUITING No Operation After Short Course Radiotherapy Followed By Consolidation Chemotherapy In Locally Advanced Rectal Cancer
Servicio de Salud Metropolitano Sur Oriente
NCT07033026 RECRUITING An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.
NGM Biopharmaceuticals, Inc
NCT05663775 RECRUITING Prophylactic Mesalamine to Prevent Colitis Following Treatment With Ipilimumab/Nivolumab (Ipi/Nivo)
AHS Cancer Control Alberta
NCT03175224 RECRUITING APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Apollomics Inc.
NCT05775146 RECRUITING SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases
AHS Cancer Control Alberta
NCT07040098 RECRUITING Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06580002 RECRUITING Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
University of California, Irvine
NCT06356584 RECRUITING Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases
Shandong Cancer Hospital and Institute
NCT06780787 RECRUITING FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery
City of Hope Medical Center
NCT07012954 RECRUITING ctDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC
Sun Yat-sen University
NCT06885385 RECRUITING A Phase 2 Study Evaluating the Safety and Efficacy of JS207 With or Without JS015 in Combination With Chemotherapy in Patients With Colorectal Cancer
Shanghai Junshi Bioscience Co., Ltd.
NCT06239194 RECRUITING Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
ModeX Therapeutics, An OPKO Health Company
NCT06057831 NOT YET RECRUITING PET/MRI in Rectal Cancer
AHS Cancer Control Alberta
NCT07021950 NOT YET RECRUITING AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer
Sun Yat-sen University
NCT05118724 ACTIVE NOT RECRUITING Atezolizumab in Patients With MSI-h/MMR-D Stage II High Risk and Stage III Colorectal Cancer Ineligible for Oxaliplatin
AIO-Studien-gGmbH
NCT04730544 ACTIVE NOT RECRUITING Two Combination Treatment Regimens of Nivolumab and Ipilimumab in Patients With dMMR and / or MSI mCRC.
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT06646445 NOT YET RECRUITING Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study.
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT05771181 RECRUITING Vitamin E Combined With Fruquintinib and Tislelizumab in Microsatellite Stabilized Metastatic Colorectal Cancer Patients
Fudan University
NCT05854498 ACTIVE NOT RECRUITING Liposomal Irinotecan With TAS102 and Bevacizumab for Patients With Metastatic Colorectal Cancer
University of Wisconsin, Madison
NCT05845450 RECRUITING Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
Gruppo Oncologico del Nord-Ovest
NCT05253846 ACTIVE NOT RECRUITING Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29
Gruppo Oncologico del Nord-Ovest
NCT04017455 ACTIVE NOT RECRUITING Neoadjuvant Treatment in Rectal Cancer With Radiotherapy Followed by Atezolizumab and Bevacizumab (TARZAN)
The Netherlands Cancer Institute
NCT07007767 NOT YET RECRUITING Exploring Sintilimab + Bevacizumab + Decitabine for Advanced pMMR/MSS Colorectal Cancer (After 2+ Prior Therapies)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT07009145 NOT YET RECRUITING QL1706 Plus Bevacizumab for Unresectable or Metastatic MSI-H/dMMR CRC
Qianfoshan Hospital
NCT07003022 RECRUITING Phase Ⅱ Clinical Trial of Cadonilimab Combined With Anti-angiogenic Agents in Metastatic dMMR/MSI-H CRC
Fudan University
NCT07000305 NOT YET RECRUITING A Study of Cetuximabβ Combined With Envolimab and mFOLFOX6 in Subjects With Advanced Colorectal Cancer
Tao Zhang
NCT06999252 NOT YET RECRUITING Rimegepant Combined With PD-1 in Liver Metastasis Colorectal Cancer Patients
Fudan University
NCT05201352 ACTIVE NOT RECRUITING Evaluation of Efficacy of Trifluridine/Tipiracil Plus an Anti-IL-1α True Human Antibody Versus Trifluridine/Tipiracil Plus Placebo in Metastatic Colorectal Cancer Patients After Failure of Oxaliplatin, Irinotecan, Fluoropyrimidine
Centre Georges Francois Leclerc
NCT05727163 RECRUITING FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients
Sun Yat-sen University
NCT05908643 RECRUITING A First-In-Human Trial of pTTL in Advanced Colorectal Cancer
Neogap Therapeutics AB
NCT06949098 RECRUITING Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer
Hebei Medical University Fourth Hospital
NCT06991465 RECRUITING Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA)
Neil Kopek
NCT05870800 RECRUITING Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER
Baylor College of Medicine
NCT05999812 ACTIVE NOT RECRUITING Clinical Trial of All-trans-retinoic Acid, Bevacizumab and Atezolizumab in Colorectal Cancer
University of Texas Southwestern Medical Center
NCT05239546 RECRUITING Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers
University of Iowa
NCT06907342 RECRUITING Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)
St. Olavs Hospital
NCT04140526 ACTIVE NOT RECRUITING Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
OncoC4, Inc.
NCT06464692 RECRUITING Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Adizutecan (ABBV-400) Moves Through the Body of Adult Participants With Unresectable Locally Advanced/Metastatic Colorectal Cancer
AbbVie
NCT04007770 ACTIVE NOT RECRUITING Acupuncture Pilot Study for Cancer-related Cognitive Function
Memorial Sloan Kettering Cancer Center
NCT06980532 RECRUITING Glumetinib Combined With Fruquintinib in the Treatment of MET Amplification or Protein Overexpression in Third-Line Unresectable Metastatic Colorectal Cancer
Liu Huang
NCT06979908 RECRUITING A Clinical Study on the Efficacy and Safety of Fruquintinib in Combination With PD-1 Monoclonal Antibody and Chidamide in Refractory MSS Metastatic Colorectal Cancer
The First Hospital of Jilin University
NCT06972498 NOT YET RECRUITING A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
NCT06589830 NOT YET RECRUITING TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer
Suzhou Teligene Ltd.
NCT06973343 NOT YET RECRUITING Sintilimab Plus Bevacizumab and Chemotherapy in MSS/pMMR Colorectal With no Liver Metastasis
Anhui Provincial Cancer Hospital
NCT03401294 RECRUITING Conversion From Unresectable To Resectable Metastatic Colorectal Cancer.
University of Saskatchewan
NCT05692024 RECRUITING COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
Massachusetts General Hospital
NCT02983578 ACTIVE NOT RECRUITING Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer
M.D. Anderson Cancer Center
NCT06959589 NOT YET RECRUITING The Efficacy and Safety of IBI351, Cetuximab β Combined With FOLFIRI as First-line /IBI351, Cetuximab β as Second-line in the Treatment of KRAS G12C-mutated Metastatic Colorectal Cancer
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT06949982 RECRUITING Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes
Sergey Orlov, MD
NCT06692959 NOT YET RECRUITING A Phase II Trial of Neoadjuvant PD-1 Vaccine PD1-Vaxx in Operable MSI High Colorectal Cancer
University of Southampton
NCT06944548 NOT YET RECRUITING Evaluation of the Effect of Adapted Physical Activity on the Modification of Lipid Metabolism During Chemotherapy for Metastatic COLorectal Cancer
Centre Georges Francois Leclerc
NCT05965531 RECRUITING Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy
Sun Yat-sen University
NCT06949215 NOT YET RECRUITING 68Ga-NYM096 PET/ CT for the Detection of ccRCC in Presurgical Patients With Complex Cystic Renal Leision
Peking Union Medical College Hospital
NCT04245865 ACTIVE NOT RECRUITING Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer
Vejle Hospital
NCT06940921 ACTIVE NOT RECRUITING SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases
Zhang Tao
NCT05736731 ACTIVE NOT RECRUITING A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression
A2 Biotherapeutics Inc.
NCT06911684 RECRUITING Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.
Sun Yat-sen University
NCT06634875 RECRUITING Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)
Buzzard Pharmaceuticals
NCT06933251 NOT YET RECRUITING PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer
Guangdong Provincial People's Hospital
NCT06923345 RECRUITING Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)
Sixth Affiliated Hospital, Sun Yat-sen University
NCT06930118 RECRUITING The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines.
Shanghai Changzheng Hospital
NCT06928584 RECRUITING Hypofractionated Radiotherapy Plus Immunotherapy Versus Conventional Radiotherapy in Locally Recurrent Rectal Cancer
Fudan University
NCT06922383 RECRUITING A Clinical Study of Arfolitixorin in Patients With mCRC
Isofol Medical AB
NCT04287868 ACTIVE NOT RECRUITING Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies
National Cancer Institute (NCI)
NCT05275374 NOT YET RECRUITING XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation
Xynomic Pharmaceuticals, Inc.
NCT06718543 RECRUITING Neoadjuvant Short-Course Radiotherapy With or Without Chemotherapy and AK112 in Locally Advanced Rectal Cancer
fan li
NCT06555133 RECRUITING Y-90, Capecitabine, and Atezolizumab for Oligometastatic CRC
Brown University
NCT06300463 RECRUITING Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases
Weill Medical College of Cornell University
NCT05194995 ACTIVE NOT RECRUITING JAB-21822 in Combination With Cetuximab in Patients With Advanced CRC and Other Solid Tumors With KRAS G12C Mutation
Allist Pharmaceuticals, Inc.
NCT05288205 RECRUITING Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation
Allist Pharmaceuticals, Inc.
NCT03548961 ACTIVE NOT RECRUITING Organ Preservation in Early Rectal Cancer Patients
Fox Chase Cancer Center
NCT06056804 ACTIVE NOT RECRUITING Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer
Beijing Friendship Hospital
NCT04969315 RECRUITING TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors
Portage Biotech
NCT06903858 RECRUITING Neoadjuvant Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer
Sun Yat-sen University
NCT05776381 NOT YET RECRUITING The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp
Vejle Hospital
NCT05784688 RECRUITING Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors
TiumBio Co., Ltd.
NCT06888843 RECRUITING Study to Evaluate the Use of Capecitabine in Monotherapy and in Combination With Oxaliplatin in Elderly Patients as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer.
Nizhny Novgorod Regional Clinical Oncology Center
NCT06890624 NOT YET RECRUITING MFOLFOXIRI Plus PD-1 Inhibitor Vs MFOLFOX6 As Neoadjuvant Therapy for Locally Advanced Colon Cancer
Sun Yat-sen University
NCT04291105 RECRUITING Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients
Vyriad, Inc.
NCT04802876 ACTIVE NOT RECRUITING Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
SOLTI Breast Cancer Research Group
NCT05426005 RECRUITING Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer
Sun Yat-sen University
NCT04585035 ACTIVE NOT RECRUITING Study to Evaluate D-1553 in Subjects With Solid Tumors
InventisBio Co., Ltd
NCT05243862 ACTIVE NOT RECRUITING Safety and Activity of PolyPEPI1018 Plus Atezolizumab in Colorectal Cancer.
Treos Bio Limited
NCT06881537 RECRUITING CapeOX Combined With Bevacizumab Plus Anti-PD1 Antibody as Neoadjuvant Therapy for Locally Recurrent Colorectal Cancer
Shanghai Changzheng Hospital
NCT06790212 NOT YET RECRUITING Neoadjuvant CAPOX Plus Ivonescimab Versus CAPOX for Locally Advanced Colon Cancer
Sun Yat-sen University
NCT05585814 RECRUITING CapeOX Combined With Bevacizumab Plus Anti-PD1 Antibody as Neoadjuvant Therapy for Microsatellite Stable Locally Advanced Rectal Cancer
Shanghai Changzheng Hospital
NCT06521866 RECRUITING Phase II Study of Serplulimab Combined with First-Line Targeted Therapy, Chemotherapy, and Radiation in Advanced Colorectal Cancer
Fudan University
NCT06698757 RECRUITING Different Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/microsatellite Instability-high, Locally Advanced Colorectal Cancer
Yugui Lian
NCT06210971 RECRUITING Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer
Hebei Medical University Fourth Hospital
NCT03965234 RECRUITING Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
Roswell Park Cancer Institute
NCT05093907 RECRUITING A Study to Evaluate Safety and Efficacy of BEY1107 in Combination with Capecitabine in Patients with Metastatic Colorectal Cancer
BeyondBio Inc.
NCT05185947 ACTIVE NOT RECRUITING Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis From Colorectal, Appendiceal, Small Bowel, Gastric, Cholangiocarcinoma, Breast, Ovarian, or Other Gynecologic Primary Cancer
National Cancer Institute (NCI)
NCT06860685 NOT YET RECRUITING Trial of Gum Chewing to Enhance the Restoration of Intestinal Motility in Colorectal Cancer Surgery
Sichuan Cancer Hospital and Research Institute
NCT04503694 RECRUITING Neoadjuvant Regorafenib in Combination with Nivolumab and Short-course Radiotherapy in Stage II-III Rectal Cancer
Jules Bordet Institute
NCT06858969 NOT YET RECRUITING Chidamide in Combination With PD-1 Inhibitor, Bevacizumab, and XELOX for Metastatic Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06855849 NOT YET RECRUITING An Open-label, Single-arm, Multicenter Phase II Study to Evaluate the Efficacy of Amivantamab in Combination With FOLFIRI as a Second-line Treatment in Patients With RAS/BRAF Wild-type Advanced Colorectal Cancer Progressing on Prior Anti-EGFR Based Treatment.
Yonsei University
NCT05057052 RECRUITING Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis
Fudan University
NCT06763029 RECRUITING Irinotecan Liposomes Combined with Cetuximab + Vermofenib in First-line Failure of Advanced Colorectal Cancer
Fudan University
NCT03957902 RECRUITING Assessment of Direct Biomarkers of Aspirin Action to Develop a Precision Chemoprevention Therapy of Colorectal Cancer
Instituto de Investigación Sanitaria Aragón
NCT06528990 RECRUITING Telehealth Intervention for Ostomy Self-Management
City of Hope Medical Center
NCT06841159 RECRUITING Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR ) Combined With Anti-PD1,Chemotherapy and Target Therapy for Metastatic Colorectal Cancer
Fudan University
NCT06840665 RECRUITING MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer
Fudan University
NCT06838546 NOT YET RECRUITING A Multicenter, Open Phase IIb Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Colorectal Cancer
Tasly Biopharmaceuticals Co., Ltd.
NCT02980510 ACTIVE NOT RECRUITING Comparison FOLFIRINOX Panitumumab vs mFOLFOX6 Panitumumab in RAS/B-RAF Wild-type Metastatic Colorectal Cancer Patients
UNICANCER
NCT06225843 RECRUITING Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis
Alethia Biotherapeutics
NCT06835179 NOT YET RECRUITING SBRT Combined With CAPEOX, Bevacizumab, and PD-1 Inhibitor for the Treatment of RAS-Mutant, MSS-Type, Unresectable Metastatic Colorectal Cancer.
The First Affiliated Hospital with Nanjing Medical University
NCT06829355 RECRUITING "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
Beijing Friendship Hospital
NCT03795311 ACTIVE NOT RECRUITING Evaluation of the Efficacy and the Safety of FOLFIRINOX3 Bevacizumab Treatment in Patients With Colorectal Cancer (FOLFIRINOX 3)
Centre Georges Francois Leclerc
NCT06282445 RECRUITING Efficacy and Safety of Chemotherapy With XELOX (Oxaliplatin + Capecitabine) and Bevacizumab in Combination With Adebrelimab in First-line Treatment of Microsatellite Stable (MSS) Initially Unresectable Metastatic Colorectal Cancer
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
NCT05672108 RECRUITING Phase II Trial of Lung Chemoemobolization
City of Hope Medical Center
NCT03255434 ACTIVE NOT RECRUITING LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy
Institut du Cancer de Montpellier - Val d'Aurelle
NCT06640166 RECRUITING Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
NCT05039177 ACTIVE NOT RECRUITING A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies
Erasca, Inc.
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Zhejiang Yangli Pharmaceutical Technology Co., Ltd.
NCT06792435 RECRUITING XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies.
Evopoint Biosciences Inc.
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Merus B.V.
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AC Camargo Cancer Center
NCT06522919 RECRUITING Sequential Immunochemotherapy Treatment with Pembrolizumab Plus Dendritic Cell (DC) Vaccine Followed by Trifluridine/Tipiracil Plus Bevacizumab in Refractory Mismatch-repair-proficient (pMMR) or Microsatellite-stable (MSS) Metastatic Colorectal Cancer
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
NCT06475352 RECRUITING Dose Individualization of Chemotherapy in Patients With Gastrointestinal Cancers Lacking a Specific Liver Enzyme
UNICANCER
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Cybrexa Therapeutics
NCT06788171 NOT YET RECRUITING PULSAR Combined With PD-1 Ab and Chemotherapy Plus Bev. for CRLM
Fujian Cancer Hospital
NCT06002789 RECRUITING Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC
Sixth Affiliated Hospital, Sun Yat-sen University
NCT06767007 RECRUITING SBRT + PD-1 Antibody in Unresectable Locally Recurrent Rectal Cancer(SPARKLE)
Sixth Affiliated Hospital, Sun Yat-sen University
NCT05555888 RECRUITING The Combination of Immunotherapy and Neoadjuvant Short-course Radiotherapy in Early Rectal Cancer
Fudan University
NCT06776757 RECRUITING Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center
NCT05167409 ACTIVE NOT RECRUITING A Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer
University of Colorado, Denver
NCT06765616 RECRUITING Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal Cancer
Feng Tian
NCT04440735 ACTIVE NOT RECRUITING A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors
Kahr Medical
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Sir Run Run Shaw Hospital
NCT06760520 NOT YET RECRUITING Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal Cancer
The First Affiliated Hospital of Zhengzhou University
NCT05688280 ACTIVE NOT RECRUITING Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
Immunophotonics, Inc.
NCT03368963 ACTIVE NOT RECRUITING TAS102 in Combination With NAL-IRI in Advanced GI Cancers
Emory University
NCT06204094 RECRUITING Node-sparing Radiotherapy Combined with Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer
Jinhua Central Hospital
NCT06760702 RECRUITING A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AUR 109 in Patients with Colorectal, Ovarian, and Renal Cancers
Aurigene Discovery Technologies Limited
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Sixth Affiliated Hospital, Sun Yat-sen University
NCT06425133 RECRUITING Regorafenib in Combination With Multimodal Metronomic Chemotherapy for Chemo-resistant Metastatic Colorectal Cancers
Centre Hospitalier Universitaire de Besancon
NCT06746545 NOT YET RECRUITING A Prospective, Open-label, Single-arm Phase II Clinical Study of Fruquintinib Combined With S-1 for the Treatment of Metastatic Colorectal Cancer.
Fujian Cancer Hospital
NCT05601505 RECRUITING Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer
Peking Union Medical College Hospital
NCT05322590 ACTIVE NOT RECRUITING BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma
Bexion Pharmaceuticals, Inc.
NCT06281678 RECRUITING A Study of IBI363 in Subjects with Advanced Solid Malignancies
Innovent Biologics (Suzhou) Co. Ltd.
NCT06542588 RECRUITING Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARC
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT04920149 RECRUITING Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Ann-Sofie Backman
NCT05121038 ACTIVE NOT RECRUITING CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab
Anup Kasi
NCT05572684 ACTIVE NOT RECRUITING A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors
NextCure, Inc.
NCT03781323 ACTIVE NOT RECRUITING Neoadjuvant FOLFOX Therapy With Short Course Radiation and Active Surveillance in Locally Advanced Rectal Cancer
University of Rochester
NCT06242418 RECRUITING CtDNA in Adjuvant Chemotherapy of Stage III Colon Cancer (REVISE Trial)
West China Hospital
NCT05731726 RECRUITING Serplulimab Combined with CAPEOX + Celecoxib As Neoadjuvant Treatment for Locally Advanced Rectal Cancer
Zhejiang University
NCT06724263 NOT YET RECRUITING A Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Malignant Solid Tumors
Tasly Biopharmaceuticals Co., Ltd.
NCT04940546 ACTIVE NOT RECRUITING Neoadjuvant Safety of Sintilimab + XELOX + Bevacizumab in PMMR/MSS CRLM Patients
Sun Yat-sen University
NCT06405139 RECRUITING Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine As Conversion Therapy of Locally Advanced Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05824975 RECRUITING A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
GI Innovation, Inc.
NCT04701476 RECRUITING TATE and Pembrolizumab (MK3475) in mCRC and NSCLC
Teclison Ltd.
NCT05969899 ACTIVE NOT RECRUITING Liposomal Irinotecan Based FOLFIRI With Bevacizumab in First-line Treatment of Advanced Colorectal Cancer
Fudan University
NCT06685276 RECRUITING Safety and Efficacy of Fruquintinib Plus Chidamide and Sintilimab in the Third and Later Line Treatment of MSS/pMMR Metastatic Colorectal Cancer
Dai, Guanghai
NCT04294264 ACTIVE NOT RECRUITING TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer
Rutgers, The State University of New Jersey
NCT06693375 RECRUITING To Evaluate Dose and Safety of NanoEcho Particle-1 Using NanoEcho Imaging Device Examinations of Rectal Lymph Nodes in Healthy Volunteers and Rectal Cancer Patients.
NanoEcho AB
NCT06612281 RECRUITING Evaluation of Gixam's Performance in a FIT Negative Population
Jubaan Ltd.
NCT06411600 RECRUITING Combination Therapy for BRAF-V600E Metastatic CRCm
Vall d'Hebron Institute of Oncology
NCT06680739 RECRUITING Single cEll pRofiling PErsistaNce To ImmuNothErapy
Vall d'Hebron Institute of Oncology
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Institut Cancerologie de l'Ouest
NCT06679673 NOT YET RECRUITING SHR-1701 Combined with SHR2554 and BP102 for MCRC
Fudan University
NCT04898504 ACTIVE NOT RECRUITING HAI-Floxuridine, or Liver-Tx, Combined With 2nd Line Chemotherapy Versus 2nd Line Chemotherapy Alone for Patients With Colorectal Liver Metastases and Heavy Tumour Burden.
Oslo University Hospital
NCT03874026 RECRUITING Study of Folfiri/Cetuximab in FcGammaRIIIa V/V Stage IV Colorectal Cancer Patients
National Cancer Institute, Naples
NCT06530303 RECRUITING Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer
Essen Biotech
NCT06598007 RECRUITING A Study to Determine the Effect of CT3001 in Patients with Advanced Solid Tumors
Crossignal Therapeutics, Inc.
NCT06665087 NOT YET RECRUITING CGA Guided Ultrafractionated RT and First-line Systemic Treatment in Elderly or Frail Patients with MCRC
Fudan University
NCT06666166 NOT YET RECRUITING SHR-A1811 Combined with Apatinib in the Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma and Colorectal Cancer
Yunpeng Liu
NCT06652412 NOT YET RECRUITING CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC
Fudan University
NCT04899908 RECRUITING Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Dana-Farber Cancer Institute
NCT06207656 RECRUITING Study to Evaluate the Efficacy and Safety of Cetuximab in Combination with Encorafenib Plus Binimetinib As Induction Treatment in BRAF V600E Mutated MSS Initially Resectable or Potentially Resectable Advanced Colorectal Cancer
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
NCT06647680 NOT YET RECRUITING Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer
The Affiliated Hospital of Qingdao University
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Salubris Biotherapeutics Inc
NCT06184698 RECRUITING Liposomal Irinotecan and Leucovorin/5-fluorouracil Plus Bevacizumab in Metastatic Colorectal Cancer
Hebei Medical University Fourth Hospital
NCT04913337 ACTIVE NOT RECRUITING Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
NGM Biopharmaceuticals, Inc
NCT05628038 RECRUITING The Combination of Hypofractionated Radiotherapy and Immunotherapy in Locally Recurrent Rectal Cancer
Fudan University
NCT04117945 ACTIVE NOT RECRUITING Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer
Academic and Community Cancer Research United
NCT06403709 ACTIVE NOT RECRUITING Irinotecan, TAS-102 Plus Bevacizumab as a Third-Line or Beyond Therapy in mCRC Patients
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05963490 RECRUITING Regorafenib Alone or in Combination With Hypofractionated/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer
Fudan University
NCT06596343 NOT YET RECRUITING Evaluating the Benefits of Personalized Traditional Chinese Medicine in Postoperative Treatment for Locally Advanced Colorectal Cancer
Sir Run Run Shaw Hospital
NCT02919644 RECRUITING Vaccination with Autologous Dendritic Cells Loaded with Autologous Tumour Homogenate After Curative Resection for Stage IV Colorectal Cancer.
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
NCT06599827 NOT YET RECRUITING Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC
Shanghai Zhongshan Hospital
NCT06603376 RECRUITING Irinotecan Hydrochloride Liposome Injection (Ⅱ) Combined with Fluorouracil, Folinic Acid, Vermofenib and Cetuximab in First-line Treatment of BRAFV600E Mutated Advanced Colorectal Cancer
Shanghai Changzheng Hospital
NCT06493760 RECRUITING A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
NCT06594692 NOT YET RECRUITING Node-Sparing Short-Course Radiation with CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: a Randomized, Prospective, Multicenter Study
Sir Run Run Shaw Hospital
NCT06590259 RECRUITING A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM
Shanghai 6th People's Hospital
NCT06593548 NOT YET RECRUITING Lvosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer
Fudan University
NCT06580574 RECRUITING Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers
Peking University
NCT06575127 RECRUITING Modified FOLFOXIRI Plus Target Therapy as a First Line Treatment for Advanced Colorectal Cancer a Prospective Phase Two Study
Al-Azhar University
NCT05913674 RECRUITING Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC)
Ciusss de L'Est de l'Île de Montréal
NCT06563986 RECRUITING FTD-TPI, Bevacizumab, and Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer
UMC Utrecht
NCT04680260 RECRUITING OPTIMIzation of Treatment SElection and Follow up in Oligometastatic Colorectal Cancer
Karen-Lise Garm Spindler
NCT03981146 ACTIVE NOT RECRUITING A Phase II Trial Assessing Nivolumab in Class II Expressing Microsatellite Stable Colorectal Cancer
University of Birmingham
NCT06341296 RECRUITING Phase II Study of Irinotecan Liposomes in First-line Treatment of Metastatic Colorectal Cancer
West China Hospital
NCT06047015 NOT YET RECRUITING Irreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer
University of Saskatchewan
NCT06543836 RECRUITING ctDNA-guided Treatment of TKI Plus PD-1 Inhibitor for Advanced pMMR/MSS Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06341309 NOT YET RECRUITING Exploratory Study of Irinotecan Liposomes in Maintenance Therapy of Metastatic Colorectal Cancer
West China Hospital
NCT06006390 RECRUITING CEA Targeting Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of CEA Positive Advanced Solid Tumors
Chongqing Precision Biotech Co., Ltd
NCT06547203 RECRUITING Cetuximab, Irinotecan, Toripalimab in RAS/BRAF Wild-type Ultraselected Right-sided Colorectal Cancer Study
Sun Yat-sen University
NCT04636008 RECRUITING Sintilimab Plus Hypofractionated Radiotherapy for MSI-H/dMMR Rectal Cancer
West China Hospital
NCT06534762 RECRUITING Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical Study
Zhejiang Provincial People's Hospital
NCT06455254 RECRUITING Cadonilimab Combined With Regorafenib as A Third-line Treatment in Patients With MSS CRLM
Jin-hong Chen
NCT06525428 RECRUITING Standard Systemic Therapy Combined With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer
Fudan University
NCT06516445 RECRUITING SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC
Huazhong University of Science and Technology
NCT06513221 NOT YET RECRUITING A Prospective Study of MSS-type Metastatic Colorectal Cancer Receiving Multiple Lines of Standard Chemotherapy, Bevacizumab Combined With Adebrelimab
Fudan University
NCT05700656 RECRUITING Galunisertib Combined With Capecitabine in Advanced CRC With PM
The Netherlands Cancer Institute
NCT06495853 NOT YET RECRUITING Prospective Phase II Study on Continuous Circumferential Reinforcement of Laparoscopic Rectal Anastomosis to Prevent Complications
ZHI-ZHONG PAN
NCT06491355 NOT YET RECRUITING First-Line Treatment Induced With mFOLFOX6 and HLX04 Regimen, Following Combined With Serplulimab in MSS Initially Unresectable Metastatic Colorectal Cancer
Sir Run Run Shaw Hospital
NCT04715633 ACTIVE NOT RECRUITING PD-1 Inhibitors Combined With VEGF Inhibitors for Locally Advanced dMMR/MSI-H Colorectal Cancer
Sun Yat-sen University
NCT05462236 RECRUITING MNK Inhibitor AUM001 in Combination With Either Pembrolizumab or Irinotecan to Treat Metastatic Colorectal Cancer
AUM Biosciences Pte Ltd
NCT06490913 NOT YET RECRUITING Chemotherapy Plus EGFR Monoclonal Antibody in Patients With Liver Metastases From Colorectal Cancer With ctDNA Superselective Negative Genes
Fujian Cancer Hospital
NCT06485713 RECRUITING Efficacy and Safety of Trifluridine/Tipiracil Combined With Fufuquitinib for Third-line Treatment of mCRC
First Affiliated Hospital of Wenzhou Medical University
NCT06484153 NOT YET RECRUITING Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT05229003 RECRUITING Irinotecan Plus Anlotinib or Further in Combination With Penpulimab for Second-line Treatment of mCRC
Fudan University
NCT06385418 RECRUITING Fluorouracil Treatment Via Colon for Colorectal Cancer
The Second Hospital of Nanjing Medical University
NCT05187338 RECRUITING Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors
Second Affiliated Hospital of Guangzhou Medical University
NCT06462053 RECRUITING Short-course Radiotherapy Combined With CAPOX and PD-1 Antibody Versus Long-course Chemoradiotherapy Combined With CAPOX for Early Low-lying Rectal Cancer
Fudan University
NCT03867799 ACTIVE NOT RECRUITING iSCORE: Immunotherapy Sequencing in COlon and REctal Cancer
Royal Marsden NHS Foundation Trust
NCT06455124 RECRUITING Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rectal Cancer (TORCH-LE)
Fudan University
NCT06440902 RECRUITING Exploration of Therapeutic Strategies for NeoRAS Wild-type Metastatic Colorectal Cancer Based on Circulating Tumor DNA
Fudan University
NCT06436976 RECRUITING The Effect of Probiotics ATG-F4 in Cancer Patients
Chungnam National University Hospital
NCT06434090 NOT YET RECRUITING Liposomal Irinotecan Plus Bevacizumab in Irinotecan-refractory Metastatic Colorectal Cancer
Sun Yat-sen University
NCT06428487 RECRUITING Neoadjuvant Prolgolimab Monotherapy in Locally Advanced MMR-deficient Colorectal Cancer
Blokhin's Russian Cancer Research Center
NCT06423937 NOT YET RECRUITING Fruquintinib Plus Camrelizumab and HAIC in the Treatment of Non-MSI-H Advanced Colorectal Cancer
Fudan University
NCT03992456 ACTIVE NOT RECRUITING Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer
Academic and Community Cancer Research United
NCT03337087 ACTIVE NOT RECRUITING Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer
Academic and Community Cancer Research United
NCT06415851 NOT YET RECRUITING Chemotherapy Plus Bevacizumab and Anti-PD-1 Followed by Induction Therapy of Chemotherapy Plus Bevacizumab
Zhangfa Song
NCT06148402 RECRUITING Fruquintinib Plus Camrelizumab and Capecitabine as Salvage Therapy After Progression on FOLFOXIRI-based First-line Treatment in Patients With Unresectable/Metastatic Colorectal Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT05965817 RECRUITING Fluorescence-guided Resection Of Colorectal Liver Metastases Using SGM-101 and Indocyanine GREEN
Leiden University Medical Center
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The First Affiliated Hospital with Nanjing Medical University
NCT06394128 RECRUITING Cangpo Liujun Prescription on Cancer-related Fatigue in Advanced Colorectal Cancer With Spleen Deficiency and Dampness Excess
First People's Hospital of Hangzhou
NCT06390982 NOT YET RECRUITING Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study
Fudan University
NCT06391905 NOT YET RECRUITING PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS
Guangdong Provincial People's Hospital
NCT06206096 RECRUITING PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC
Chinese PLA General Hospital
NCT06255379 NOT YET RECRUITING Study of Fruquintinib Combined With Tegafur Gimeracil Oteracil in Patients With Metastatic Colorectal Cancer
Guangzhou University of Traditional Chinese Medicine
NCT04301557 ACTIVE NOT RECRUITING PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer
Sun Yat-sen University
NCT06379399 RECRUITING Trifluridine/Tipiracil Combined With Cetuximab in the Treatment of Third-line and Above RAS/BRAF Wild-type mCRC
Wangxia LV
NCT05228431 RECRUITING Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer
Zhen-Hai Lu
NCT06373133 NOT YET RECRUITING SHR-8068 Combined With Adbelizumab and BP102 in the Treatment of Advanced Colorectal Cancer
West China Hospital
NCT06363552 NOT YET RECRUITING A Study of SC-0191 in Subjects With Metastatic Colorectal Cancer
Tianshu Liu
NCT06014372 RECRUITING Envafolimab Monotherapy or Envafolimab + CAPEOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer
Sun Yat-sen University
NCT06202001 RECRUITING Irinotecan, TAS-102 Plus Bevacizumab as a Second-Line Therapy in mCRC Patients
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT04543695 ACTIVE NOT RECRUITING A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06265025 RECRUITING GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors
GeneMedicine Co., Ltd.
NCT05806931 RECRUITING Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer
Rutgers, The State University of New Jersey
NCT06321081 RECRUITING ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC
Beijing Hospital
NCT06304987 NOT YET RECRUITING Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer
Beijing Friendship Hospital
NCT06234007 RECRUITING Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT06304545 NOT YET RECRUITING Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab
Harbin Medical University
NCT06301386 NOT YET RECRUITING Everolimus Combined With PD-1 in Advanced Colorectal Cancer Patients
Fudan University
NCT05022030 RECRUITING First-line mCapOX+Cetuximab vs. mFOLFOX6+Cetuximab for Metastatic Left-sided CRC With Wild-type RAS/BRAF Genes
West China Hospital
NCT05111860 RECRUITING Neoadjuvant Bevacizumab + Chemotherapy Combined With Short-course Radiotherapy
Shanghai Minimally Invasive Surgery Center
NCT06293014 RECRUITING TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer
Henan Cancer Hospital
NCT06270017 RECRUITING Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer Using Zebra Fish Avatars
University Hospital, Linkoeping
NCT05007132 RECRUITING Trifluridine/ Tipiracil Plus Panitumumab Versus Trifluridine/ Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer
Dominik Paul Modest
NCT06254521 RECRUITING The Effects of Neoadjuvant Tislelizumab Combined With Chemotherapy in Locally Advanced MSS Rectal Cancer
First Affiliated Hospital of Guangxi Medical University
NCT06242067 RECRUITING Second-line Treatment of Metastatic Colorectal Cancer
Qilu Hospital of Shandong University
NCT05526079 RECRUITING Watchful Waiting for Complete Responders to Therapy in Rectal Cancer
Henry Ford Health System
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N.N. Petrov National Medical Research Center of Oncology
NCT06218888 NOT YET RECRUITING A Phase II Clinical Study of the Efficacy and Safety of Tislelizumab Combined With Fruquintinib and Chidamide in the Treatment of Unresectable or Advanced Microsatellite Stabilized (MSS/pMMR) Colorectal Cancer With Liver Metastases
Fujian Cancer Hospital
NCT06218810 RECRUITING Cadonilimab in Combination With Bevacizumab and FOLFOX Regimen for the First-Line Treatment of Advanced Unresectable MSS-Type, RAS-Mutated Metastatic Colorectal Cancer
Fudan University
NCT06192680 NOT YET RECRUITING Liposomal Irinotecan and Capecitabine Plus Bevacizumab as Second-line Therapy in Metastatic Colorectal Cancer
Harbin Medical University
NCT05245474 RECRUITING Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer
Beijing Friendship Hospital
NCT04235114 RECRUITING Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
University of Saskatchewan
NCT06195670 NOT YET RECRUITING Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC
Zhejiang Cancer Hospital
NCT06176885 RECRUITING Efficacy and Safety of Combined With Immunotherapy After Induction Therapy With Chemotherapy and Targeted Therapy in the First-line Treatment of Microsatellite Stable (MSS) Initially Unresectable Metastatic Colorectal Cancer
yue junhan
NCT04889742 NOT YET RECRUITING Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
Charite University, Berlin, Germany
NCT06168786 RECRUITING Cadonilimab Combined With Fruquintinib and SBRT as Athird-line and Posterior Line Treatment in Patients With MSS CRC
Huazhong University of Science and Technology
NCT05092880 RECRUITING Radioembolization in Elderly/ Fragile Patients With mCRC
UMC Utrecht
NCT05360277 RECRUITING Maintenance Tislelizumab + Capecitabine to Treat Metastatic Colorectal Cancer
Yanhong Deng
NCT06162650 RECRUITING Total Neoadjuvant Therapy in Rectal Cancer
National Cheng-Kung University Hospital
NCT06152523 NOT YET RECRUITING Monalizumab and MEDI5752 in Patients With MSI and/or dMMR Metastatic Cancer
Assistance Publique - Hôpitaux de Paris
NCT05985109 RECRUITING KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer
Peking University Cancer Hospital & Institute
NCT06099951 NOT YET RECRUITING Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy
Sun Yat-sen University
NCT03840239 ACTIVE NOT RECRUITING TNT to Increase the Clinical Complete Response Rate for Distal LARC
Sun Yat-sen University
NCT06092242 NOT YET RECRUITING The Efficacy and Safety of TAS-102(Suyuan) Combined With Bevacizumab as First-line Therapy in Patients With Advanced Colorectal Cancer
The Second Affiliated Hospital of Shandong First Medical University
NCT05450029 RECRUITING Neoadjuvant Chemoradiotherapy Plus Sintilimab for Intermediate/High Immunoscore Locally Advanced Rectal Cancer
Yanhong Deng
NCT06018714 RECRUITING Efficacy of Modified Fruquintinib in Colorectal Cancer Liver Metastases: A Phase II Study
Sun Yat-sen University
NCT06014944 NOT YET RECRUITING Short-course Radiotherapy Combined With Furoquintinib and PD-1 Monoclonal Antibody
Changhai Hospital
NCT05962502 RECRUITING Cetuximab Plus Irinotecan in Patients With NeoRAS Wild-type Metastatic Colorectal Cancer In Third-line Therapy
Sun Yat-sen University
NCT06010888 RECRUITING Fruquintinib With mFOLFOX6/FOLFIRI as First-Line Therapy for Conversion Surgery in mCRC
Fudan University
NCT05957016 RECRUITING Neoadjuvant CIETAI With Concurrent Chemoradiotherapy in Local Advanced Rectal Cancer
Third Military Medical University
NCT05985707 NOT YET RECRUITING KN026 Plus Chemotherapy ± KN-046 in HER2 Positive Colorectal Cancer and Biliary Carcinoma
Peking University Cancer Hospital & Institute
NCT05998122 NOT YET RECRUITING Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory Study
The First Hospital of Jilin University
NCT05969847 NOT YET RECRUITING Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer
池畔
NCT05970302 RECRUITING XELOX +Bev +Tislelizumab for First-line Treatment of MSS/pMMR RAS-mutated mCRC
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05970705 RECRUITING Regorafenib Combined With TAS-102 Versus Regorafenib Monotherapy in Third or Later Line Therapy of mCRC
Fudan University
NCT05939661 RECRUITING A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer
Osaka University
NCT05909423 NOT YET RECRUITING Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer
Zealand University Hospital
NCT05841134 NOT YET RECRUITING Tislelizumab Combined With Chemotherapy (CAPOX) in the Perioperative Treatment of MSI-H/dMMR Stage II or III Colorectal Cancer
The First Affiliated Hospital of Zhengzhou University
NCT05815290 RECRUITING Cadonilimab in Locally Advanced MSI-H/dMMR Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05815303 RECRUITING XELOX Combined With Cadonilimab Versus XELOX as Neoadjuvant Treatment for Locally Advanced, pMMR Rectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05807984 NOT YET RECRUITING Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon Ion
Xin Cai
NCT05794750 NOT YET RECRUITING Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC(AK104-IIT-13)
JIN JING
NCT05733000 RECRUITING CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors
Northwestern University
NCT05136326 RECRUITING Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
NCT05747716 NOT YET RECRUITING SBRT Combined With Fruquintinib Plus PD-1/CTLA-4 Antibody for Third-line Treatment in mCRC
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT05742425 RECRUITING Serplulimab Combined With FOLFIRI and Bevacizumab in the Treatment of Colon Cancer Peritoneal Metastases
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT05725200 RECRUITING Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer
Oslo University Hospital
NCT05167448 ACTIVE NOT RECRUITING A Study of ES104 in Patients With Metastatic Colorectal Cancer
Elpiscience (Suzhou) Biopharma, Ltd.
NCT05720559 NOT YET RECRUITING Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection
Liaoning Cancer Hospital & Institute
NCT04014530 RECRUITING Pembrolizumab With Ataluren in Patients With Metastatic pMMR and dMMR Colorectal Carcinoma or Metastatic dMMR Endometrial Carcinoma: the ATAPEMBRO Study
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT04304209 ACTIVE NOT RECRUITING Pd1 Antibody Sintilimab ± Chemoradiotherapy for Locally Advanced Rectal Cancer
Sun Yat-sen University
NCT04833387 ACTIVE NOT RECRUITING PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer
Sun Yat-sen University
NCT05640726 NOT YET RECRUITING The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy
Fujian Cancer Hospital
NCT05359393 NOT YET RECRUITING A Combination Therapy Including Anti-PD-1 Immunotherapy in MSS Rectal Cancer With Resectable Distal Metastasis
Fudan University
NCT03280511 RECRUITING Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in Resected High Risk Colon Cancer Patients
Michael Bau Mortensen
NCT05563922 RECRUITING Organ Preservation Strategy of Total Neoadjuvant Chemoradiotherapy for Low Rectal Carcinoma
Shanghai Zhongshan Hospital
NCT05507112 NOT YET RECRUITING TIME in Immunotherapy Combined With nCRT for Rectal Cancer
Peking Union Medical College Hospital
NCT05300269 RECRUITING SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT05364489 NOT YET RECRUITING Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancer
The First Affiliated Hospital of Zhengzhou University
NCT05378919 RECRUITING Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer
Lithuanian University of Health Sciences
NCT05350917 NOT YET RECRUITING Study of Tislelizumab Combined With DisitamabVedotin and Pyrotinib Maleate in HER2-positive or Mutated Advanced Colorectal Cancer Who Failed Standard Therapy
The First Affiliated Hospital of Zhengzhou University
NCT05239650 NOT YET RECRUITING Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX07+HLX10 +mFOLFOX6 or HLX07 Monotherapy in Patients With mCRC
Shanghai Henlius Biotech
NCT05220800 NOT YET RECRUITING Effects of Intravenous Administered Iron in Non-anemic Iron Deficient Patients With Colorectal Cancer
Zealand University Hospital
NCT04845490 NOT YET RECRUITING Comparative Study of Mitomycin and Lobaplatin in Advanced Colorectal Cancer Patients With Radical Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT05231850 NOT YET RECRUITING A Phase II Study of Tislelizumab as Adjuvant Therapy for Patients With Stage Ⅱ and Stage Ⅲ Colon Cancer and dMMR/MSI.
The First Affiliated Hospital of Zhengzhou University
NCT04109755 RECRUITING Neo-adjuvant Pembrolizumab and Radiotherapy in Localised MSS Rectal Cancer
University Hospital, Geneva
NCT05054959 RECRUITING Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence
Institute of Oncology Ljubljana
NCT04838496 NOT YET RECRUITING Induction Chemotherapy for Locally Advanced Rectal Cancer
Catharina Ziekenhuis Eindhoven
NCT04695782 RECRUITING Pencil Beam Proton Therapy for Pelvic Recurrences in Rectal Cancer Patients Previously Treated With Radiotherapy
University of Aarhus
NCT04443543 NOT YET RECRUITING An Adaptive-design Prospective Cohort Study of Watch and Wait Strategy in Patients With Locally Advanced Rectal Cancer
Fudan University
NCT03391843 ACTIVE NOT RECRUITING Neoadjuvant Chemotherapy Combined With Cetuximab for EGFR Wild Type Locally Advanced Rectal Cancer
RenJi Hospital
NCT05223036 SUSPENDED Testing Obeticholic Acid for Familial Adenomatous Polyposis
National Cancer Institute (NCI)
NCT06608537 COMPLETED A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant Chemoradiotherapy for MSS Rectal Cancer
Sun Yat-sen University
NCT03828799 COMPLETED Safety, Tolerability and Efficacy of Regorafenib in Combination With FOLFIRINOX in Patients With Colorectal Cancer
Institut du Cancer de Montpellier - Val d'Aurelle
NCT07223567 WITHDRAWN A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer
M.D. Anderson Cancer Center
NCT07011550 SUSPENDED Phase 2, Single-arm Trial of BMS-986340 in Association With Nivolumab, Trifluridine/Tipiracil and Bevacizumab for Patients Refractory to Standard of Care Treatment and With Microsatellite-stable Colorectal Cancer
M.D. Anderson Cancer Center
NCT03785210 TERMINATED Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic Cancers
National Cancer Institute (NCI)
NCT04426669 COMPLETED A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering
Intima Bioscience, Inc.
NCT05983367 TERMINATED A Study to Investigate Ompenaclid Combined With FOLFIRI Plus Bevacizumab in Advanced/Metastatic Colorectal Cancer
Inspirna, Inc.
NCT06603818 WITHDRAWN Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)
National Cancer Institute (NCI)
NCT02738606 TERMINATED Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery
M.D. Anderson Cancer Center
NCT07071961 SUSPENDED Regorafenib (Reg) and Lorigerlimab (Lor), RELO Regimen, in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy [ReLOAD Trial]
M.D. Anderson Cancer Center
NCT05116085 COMPLETED Efficacy and Safety of Tislelizumab (BGB-A317) as Neo-Adjuvant Treatment in Participants With Colorectal Cancer
BeiGene
NCT03388190 COMPLETED METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin
University Hospital, Akershus
NCT06501989 WITHDRAWN Study of 5-fluorouracil (5-FU) in Patients With Metastatic Colorectal Cancer
Inova Health Care Services
NCT06307548 SUSPENDED Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer
Roswell Park Cancer Institute
NCT04109924 COMPLETED TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study
Roswell Park Cancer Institute
NCT03365882 COMPLETED S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery
SWOG Cancer Research Network
NCT07323576 WITHDRAWN A Study to Evaluate the Efficacy and Safety of Inavolisib When Administered in Combination With Bevacizumab and FOLFOX or FOLFIRI as First Line Therapy in Participants With Colorectal Cancer
Hoffmann-La Roche
NCT04332653 COMPLETED NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
NeoImmuneTech
NCT03693807 COMPLETED A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma
Memorial Sloan Kettering Cancer Center
NCT05062889 SUSPENDED Exploiting Circulating Tumour DNA to Intensify the Postoperative Treatment Resected Colon Cancer Patients
Gruppo Oncologico del Nord-Ovest
NCT05733611 TERMINATED RP2/RP3 in Combination With Atezolizumab and Bevacizumab for the Treatment of Patients With CRC
Replimune Inc.
NCT05731947 COMPLETED Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
Syndax Pharmaceuticals
NCT07137390 WITHDRAWN A Trial of Regorafenib Plus Lorigerlimab as Neoadjuvant Therapy for Patients With pMMR/MSS, Resectable, Lung-limited Metastatic Colorectal Cancer
M.D. Anderson Cancer Center
NCT05641896 COMPLETED Study of [18F]FAPI-74 PET in Patients With Gastrointestinal Cancers
SOFIE
NCT04505553 COMPLETED Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer
University of Washington
NCT06006923 TERMINATED Regorafenib in Combination With Pembrolizumab or Pembrolizumab for MSI-H Colorectal Cancer
Anwaar Saeed
NCT04744831 COMPLETED Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer
Daiichi Sankyo
NCT05002270 COMPLETED JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation
Jacobio Pharmaceuticals Co., Ltd.
NCT03366155 COMPLETED Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver
National Cancer Institute (NCI)
NCT06332079 TERMINATED Holmium-166 TARE in Liver Limited Unresectable Colorectal Cancer Patients
Gruppo Oncologico del Nord-Ovest
NCT03844750 TERMINATED Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases
Chloe Atreya, MD, PhD
NCT04417699 COMPLETED SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer
Providence Health & Services
NCT06071052 COMPLETED TACE Plus HAIC Combined With Regorafenib for Liver Metastasis of Colorectal Cancer Refractory to Standard Treatment Regimens
First Affiliated Hospital, Sun Yat-Sen University
NCT02437071 COMPLETED Assess the Efficacy of Pembrolizumab Plus Radiotherapy or Ablation in Metastatic Colorectal Cancer Patients
Memorial Sloan Kettering Cancer Center
NCT04844073 TERMINATED A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer
Takeda
NCT02921256 COMPLETED Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer
National Cancer Institute (NCI)
NCT03377361 COMPLETED An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Cancer of the Colon or Rectum That Has Spread
Bristol-Myers Squibb
NCT06493240 COMPLETED Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer
Peking University People's Hospital
NCT03984578 COMPLETED Window of Opportunity Study in Colorectal Cancer
National Cancer Centre, Singapore
NCT05256381 TERMINATED A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors
SOTIO Biotech AG
NCT03797326 COMPLETED Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
Merck Sharp & Dohme LLC
NCT05935748 TERMINATED Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)
NiKang Therapeutics, Inc.
NCT05119335 TERMINATED A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma
NiKang Therapeutics, Inc.
NCT05194735 TERMINATED Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors
Alaunos Therapeutics
NCT04208958 COMPLETED Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer
Vedanta Biosciences, Inc.
NCT06557278 WITHDRAWN Combined AlloStim+Anti-PD-L1 in 4L MSS Metastatic Colorectal Cancer
Mirror Biologics, Inc.
NCT04660812 COMPLETED An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer.
Arcus Biosciences, Inc.
NCT04444622 COMPLETED Immunotherapy for Third Line Metastatic Colorectal Cancer
Mirror Biologics, Inc.
NCT03184870 COMPLETED A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Participants With Advanced Solid Tumors
Bristol-Myers Squibb
NCT06730100 WITHDRAWN CBX-12 for the Treatment of Metastatic Chemotherapy-Refractory Microsatellite Stable Colorectal Cancer
National Cancer Institute (NCI)
NCT04985604 TERMINATED Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors
Day One Biopharmaceuticals, Inc.
NCT02982694 TERMINATED Study With Atezolizumab Plus Bevacizumab in Patients With Chemotherapy Resistant, MSI-like, Colorectal Cancer
Vall d'Hebron Institute of Oncology
NCT05510895 COMPLETED Neoadjuvant Encorafenib, Binimetinib and Cetuximab for Patients With BRAF V600E Mutated/pMMR Localized Colorectal Cancer
AIO-Studien-gGmbH
NCT05350501 TERMINATED EO2040 in Combination With Nivolumab, for Treatment of Patients With Minimal Residual Disease of Colorectal Cancer
Enterome
NCT05104567 COMPLETED A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)
Sanofi
NCT04701281 TERMINATED Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer
AllVascular
NCT03711058 COMPLETED Study of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04278144 TERMINATED A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors
Bolt Biotherapeutics, Inc.
NCT05678257 TERMINATED A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer
NuCana plc
NCT06410534 WITHDRAWN A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer
National Cancer Institute (NCI)
NCT06690281 WITHDRAWN A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies
National Cancer Institute (NCI)
NCT02978612 COMPLETED Adjuvant Chemotherapy In Elderly With Colon Cancer Stage III
Oslo University Hospital
NCT04031872 WITHDRAWN LY3200882 and Capecitabine in Advanced Resistant TGF-beta Activated Colorectal Cancer (EORTC1615)
The Netherlands Cancer Institute
NCT05775900 COMPLETED Efficacy and Safety of Triweekly Cetuximab in Combination With Capecitabine as First-line Maintenance Treatment for KRAS/BRAF Wild-type Metastatic Colorectal Cancer
Sun Yat-sen University
NCT06084689 WITHDRAWN Targeting MDMD and PD1 in Tumors With Tertiary Lymphoid Structures
Institut Bergonié
NCT03732781 COMPLETED Study of Radspherin® in Colorectal Carcinoma Subjects With Peritoneal Carcinomatosis Treated With HIPEC
Oncoinvent Solutions AS
NCT05589597 TERMINATED EO4010 in Previously Treated Metastatic Colorectal Carcinoma
Enterome
NCT05259696 COMPLETED Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)
Palleon Pharmaceuticals, Inc.
NCT06333769 COMPLETED Modified SCRT Followed by Tislelizumab Plus CAPOX for Locally Advanced Rectal Cancer
Fujian Cancer Hospital
NCT03314935 COMPLETED A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors
Incyte Corporation
NCT05480306 COMPLETED Phase 2 Study of DKN-01 in Colorectal Cancer
Leap Therapeutics, Inc.
NCT03482362 COMPLETED Vinorelbine in Advanced BRAF-like Colon Cancer
The Netherlands Cancer Institute
NCT05591534 SUSPENDED Endorectal Brachytherapy for Rectal Cancer
University Hospital, Bordeaux
NCT05619172 TERMINATED A Study of Nanrilkefusp Alfa (SOT101) in Combination With Cetuximab to Evaluate the Efficacy and Safety in Patients With Colorectal Cancer
SOTIO Biotech AG
NCT03547999 TERMINATED A Trial of Perioperative CV301 Vaccination in Combination With Nivolumab and Systemic Chemotherapy for Metastatic CRC
Patrick Boland
NCT05714553 TERMINATED NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
NuCana plc
NCT04577963 TERMINATED A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors
Hutchmed
NCT05563272 TERMINATED 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
Telix Pharmaceuticals (Innovations) Pty Ltd
NCT02611024 COMPLETED Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors
PharmaMar
NCT04786600 TERMINATED A Phase II Randomized Therapeutic Optimization Trial for Subjects With Refractory Metastatic Colorectal Cancer Using ctDNA: Rapid 1 Trial
University of Florida
NCT05330429 TERMINATED Study of Magrolimab Given Together With FOLFIRI/Bevacizumab (BEV) in Participants With Previously Treated Advanced Inoperable Metastatic Colorectal Cancer (mCRC)
Gilead Sciences
NCT03442569 COMPLETED PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC
UNC Lineberger Comprehensive Cancer Center
NCT03186326 COMPLETED Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic Cancer
Federation Francophone de Cancerologie Digestive
NCT03584711 COMPLETED FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation
Federation Francophone de Cancerologie Digestive
NCT05513742 COMPLETED A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer
Compass Therapeutics
NCT02368886 COMPLETED Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer
Academic and Community Cancer Research United
NCT04625803 COMPLETED Neoadjuvant Therapy for Locally Advanced Colon Cancer
Zhejiang University
NCT04616196 COMPLETED Study of NKTR 255 in Combination With Cetuximab in Solid Tumors
Nektar Therapeutics
NCT03037385 COMPLETED Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
Hoffmann-La Roche
NCT05546476 COMPLETED Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
Pfizer
NCT04068896 COMPLETED Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy
NGM Biopharmaceuticals, Inc
NCT04442126 TERMINATED A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors
Numab Therapeutics AG
NCT06895577 WITHDRAWN Neoadjuvant Chemoradiotherapy Plus Sintilimab for MSS, Locally Advanced Rectal Cancer-
Sun Yat-sen University
NCT06804876 COMPLETED COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients
Zhejiang University
NCT04479436 TERMINATED A Study to Evaluate U3-1402 in Subjects With Advanced or Metastatic Colorectal Cancer
Daiichi Sankyo
NCT02380443 COMPLETED AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer
Mirror Biologics, Inc.
NCT03879811 WITHDRAWN Determining the Effects of Temozolomide Followed by Nivolumab in Patients With Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04579757 TERMINATED Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors
Hutchmed
NCT04853043 TERMINATED Cetuximab in Third Line for Mutant APC, TP53 and RAS Patients With Refractory Metastatic Colorectal Cancer
University of Utah
NCT06137248 COMPLETED Study to Assess Colonic Microbiota Changes in Response to Energy Drink Consumption
University of Florida
NCT02632448 COMPLETED A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma Inc.
NCT04495621 COMPLETED MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01)
Menarini Group
NCT04491955 COMPLETED Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers
National Cancer Institute (NCI)
NCT03428958 COMPLETED A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment
NuCana plc
NCT03610490 TERMINATED Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma
M.D. Anderson Cancer Center
NCT04907539 COMPLETED A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)
Redx Pharma Ltd
NCT05004350 COMPLETED A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.
Pierre Fabre Medicament
NCT04383210 TERMINATED Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
Elevation Oncology
NCT04450836 TERMINATED Sequences Of REGorafenib And Trifluridine/Tipiracil in Patients With Metastatic Colorectal Cancer
UNICANCER
NCT05375708 SUSPENDED Systemic Therapy in Combination with Stereotactic Radiotherapy in Patients with Metastatic Colorectal Cancer Up to 10 Metastatic Sites
UMC Utrecht
NCT04952753 TERMINATED Study of NIS793 and Other Novel Investigational Combinations With SOC Anti-cancer Therapy for the 2L Treatment of mCRC
Novartis Pharmaceuticals
NCT03724851 COMPLETED Vactosertib in Combination with Pembrolizumab in Metastatic Colorectal or Gastric Cancer
MedPacto, Inc.
NCT02437136 COMPLETED Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)
Syndax Pharmaceuticals
NCT04256707 COMPLETED Relative Bioavailability/Bioequivalence of Different Formulations of Selinexor, the Impact of Hepatic Impairment on Selinexor Pharmacokinetics, Tolerability and Antitumor Activity of Selinexor Combination Treatment
Karyopharm Therapeutics Inc
NCT02649790 COMPLETED Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications
Karyopharm Therapeutics Inc
NCT04976660 WITHDRAWN TT-4 As a Single Agent in Subjects with Advanced Selected Solid Tumors
Tarus Therapeutics, Inc.
NCT04072198 COMPLETED Nivolumab Plus FOLFOXIRI/Bevacizumab in First Line Chemotherapy of Advanced Colorectal Cancer RASm/BRAFm Patients
Gruppo Oncologico Italiano di Ricerca Clinica
NCT05061017 COMPLETED Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/Refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (mCRC)
Diwakar Davar
NCT03829410 COMPLETED Onvansertib in Combination With FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer Patients With a KRAS Mutation
Cardiff Oncology
NCT03396926 COMPLETED Pembrolizumab, Capecitabine, and Bevacizumab for Treating Colorectal Cancer
University of California, San Francisco
NCT03058289 COMPLETED A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6
Intensity Therapeutics, Inc.
NCT04380337 COMPLETED Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer
Stanford University
NCT03169777 WITHDRAWN QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC
ImmunityBio, Inc.
NCT06834399 TERMINATED TATE and KN046 in MCRC
Zhejiang Raygene Pharmaceuticals Co., Ltd
NCT03190174 COMPLETED Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers
Sarcoma Oncology Research Center, LLC
NCT04696757 COMPLETED Non-OpeRative MANagement of Rectal Cancer Patients
Kangbuk Samsung Hospital
NCT04666688 COMPLETED LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors
PureTech
NCT05792735 COMPLETED Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer
Shenzhen People's Hospital
NCT03117972 TERMINATED Chemotherapy Intensification in Patients With High Lactate Dehydrogenase Values and Soluble Syndecan1 Levels
Centre Hospitalier Universitaire de Besancon
NCT06365970 WITHDRAWN Niraparib and Dostarlimab for Patients With MMR-D/MSI-H Colorectal Cancers
Ibrahim Halil Sahin
NCT03764137 WITHDRAWN Imaging with [89Zr]Panitumumab-PET/MRI in Patients with Newly Diagnosed Colorectal Cancer
University of Alabama at Birmingham
NCT03047837 TERMINATED A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose ASA and Metformin in Stage I-III Crc Patients
Ente Ospedaliero Ospedali Galliera
NCT04895137 COMPLETED mFOLFOX6+Bevacizumab+PD-1 Monoclonal Antibody in Local Advanced MSS CRC
Sixth Affiliated Hospital, Sun Yat-sen University
NCT04518280 COMPLETED Short-course Radiotherapy Based TNT Combined With PD-1 Inhibitor for Locally Advanced Rectal Cancer
Fudan University
NCT05593328 COMPLETED Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation
Cardiff Oncology
NCT04513951 COMPLETED AVELUMAB and CETUXIMAB and mFOLFOXIRI as Initial Therapy for Unresectable Metastatic Colorectal Cancer Patients
Gruppo Oncologico del Nord-Ovest
NCT03841305 COMPLETED Simultaneous Portal and Hepatic Vein Versus Portal Vein Embolizations for Hypertrophy of the Future Liver Remnant
University Hospital, Montpellier
NCT03565029 COMPLETED Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer
Niguarda Hospital
NCT05500508 TERMINATED Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Aminex Therapeutics, Inc.
NCT04534218 COMPLETED Regorafenib in Combination With Metronomic Chemotherapies, and Low-dose Aspirin in Metastatic Colorectal Cancer
Centre Hospitalier Universitaire de Besancon
NCT02861300 COMPLETED CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer
David Bajor, MD
NCT03563157 TERMINATED QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine
ImmunityBio, Inc.
NCT04508140 TERMINATED Study of BO-112 With Pembrolizumab for Colorectal or Gastric/GEJ Cancer With Liver Metastasis
Highlight Therapeutics
NCT03436563 COMPLETED M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability
M.D. Anderson Cancer Center
NCT06575725 WITHDRAWN Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer
City of Hope Medical Center
NCT03225989 COMPLETED Trial Investigating an Immunostimulatory Oncolytic Adenovirus for Cancer
Lokon Pharma AB
NCT03761914 COMPLETED Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advanced Cancers
Sellas Life Sciences Group
NCT04258111 TERMINATED IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR)/microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd.
NCT04840186 SUSPENDED EXtended CriteriA Treatment for LIver Metastases and Heavy Tumour BURden
Oslo University Hospital
NCT05584137 TERMINATED Evaluate the Efficacy, Safety and Tolerability of HLX26 and Serplulimab in Patients with MCRC
Shanghai Henlius Biotech
NCT03435107 COMPLETED Durvalumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer
Asan Medical Center
NCT03259035 COMPLETED NEO: Neoadjuvant Chemotherapy, Excision and Observation for Early Rectal Cancer
Canadian Cancer Trials Group
NCT03207867 TERMINATED A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma
Novartis Pharmaceuticals
NCT03164655 COMPLETED Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network
UNICANCER
NCT05397171 TERMINATED A First-in-human Study to Evaluate the Safety and Tolerability of AZD8853 in Participants With Selected Advanced/Metastatic Solid Tumours
AstraZeneca
NCT05518032 WITHDRAWN Pembrolizumab and Autologous Dendritic Cells for the Treatment of Refractory Colorectal Cancer (CRC)
Roswell Park Cancer Institute
NCT03108066 COMPLETED MK-3795 (PT2385) for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma (MK-3795-003)
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT05356897 WITHDRAWN Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T Study
Academic and Community Cancer Research United
NCT03475004 COMPLETED Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer
University of Colorado, Denver
NCT03800602 COMPLETED Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer
Emory University
NCT02466009 COMPLETED Regorafenib in Metastatic Colorectal Cancer
University of Rochester
NCT02860546 COMPLETED A Study Evaluating TAS-102 Plus Nivolumab in Patients With MSS CRC
Taiho Oncology, Inc.
NCT03263429 COMPLETED Novel PET/CT Imaging Biomarkers of CB-839 in Combination With Panitumumab and Irinotecan in Patients With Metastatic and Refractory RAS Wildtype Colorectal Cancer
Vanderbilt-Ingram Cancer Center
NCT02705300 COMPLETED Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal Cancer
Vejle Hospital
NCT03473925 COMPLETED Efficacy and Safety Study of Navarixin (MK-7123) in Combination With Pembrolizumab (MK-3475) in Adults With Selected Advanced/Metastatic Solid Tumors (MK-7123-034)
Merck Sharp & Dohme LLC
NCT02431676 COMPLETED Survivorship Promotion In Reducing IGF-1 Trial
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02873195 COMPLETED Capecitabine and Bevacizumab With or Without Atezolizumab in Treating Patients With Refractory Metastatic Colorectal Cancer
Academic and Community Cancer Research United
NCT03981614 COMPLETED Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer
Academic and Community Cancer Research United
NCT03267316 COMPLETED A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors
Cantargia AB
NCT05086627 COMPLETED Short-course Radiotherapy Followed by Tislelizumab + CapeOX in the Treatment for Locally Advanced Rectal Cancer
Hebei Medical University Fourth Hospital
NCT02743221 COMPLETED A Study Evaluating S 95005 Plus Bevacizumab and Capecitabine Plus Bevacizumab in Patients With Previously Untreated Colorectal Cancer Who Are Non-eligible for Intensive Therapy
Institut de Recherches Internationales Servier
NCT05662527 COMPLETED Response to Immunotherapy in MMR-deficient Localized Colon Cancer
Camilla Qvortrup
NCT03127098 TERMINATED QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer
NantCell, Inc.
NCT04231526 WITHDRAWN Pembrolizumab in Early Stage Colon Cancer
University of Chicago
NCT04408599 TERMINATED A Safety and Tolerability Study of NC410 in Subjects With Advanced or Metastatic Solid Tumors
NextCure, Inc.
NCT03274882 COMPLETED Study of Efficacy and Safety of S 95005 (TAS-102) in Patients With Metastatic Colorectal Cancer Who Failed Standard Chemotherapies
Institut de Recherches Internationales Servier
NCT05039944 TERMINATED SI-B001 as a Single Agent or in Combination With Chemotherapy in the Treatment of Digestive System Malignancies
Sichuan Baili Pharmaceutical Co., Ltd.
NCT05690035 WITHDRAWN Tislelizumab Combined With Fruquintinib for Metastatic pMMR/MSS Colorectal Cancer
Sun Yat-sen University
NCT03631641 TERMINATED Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy
John Hays
NCT02581059 TERMINATED Efficacy of Ginseng for Patients on Regorafenib
Wake Forest University Health Sciences
NCT02834052 COMPLETED Pembrolizumab + Poly-ICLC in MRP Colon Cancer
Asha Nayak
NCT03144804 COMPLETED A Phase 2 Study of Lamivudine in Patients With p53 Mutant Metastatic Colorectal Cancer
Massachusetts General Hospital
NCT05609656 TERMINATED Electroporation and Immunotherapy in Metastatic Colorectal Cancer
Ismail Gögenur
NCT02291289 COMPLETED A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC)
Hoffmann-La Roche
NCT04216251 COMPLETED PRevention Using EPA Against coloREctal Cancer
Massachusetts General Hospital
NCT03146962 COMPLETED High Dose Vitamin C Intravenous Infusion in Patients With Resectable or Metastatic Solid Tumor Malignancies
Weill Medical College of Cornell University
NCT04205955 COMPLETED Testing Diet Intervention Versus Non-Diet Intervention for Management of Bowel Symptoms in Rectal Cancer Survivors
SWOG Cancer Research Network
NCT05648006 TERMINATED First-line Maintenance of OH2 Injection for Advanced Colorectal Cancer
Binhui Biopharmaceutical Co., Ltd.
NCT05900648 WITHDRAWN Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy (RX-CROME)
M.D. Anderson Cancer Center
NCT04808362 TERMINATED Phase 1/2 Study to Evaluate Safety, PK and Efficacy of the MYC-Inhibitor OMO-103 in Solid Tumours
Peptomyc S.L.
NCT04271813 COMPLETED Anlotinib Plus Sintilimab as First-line Treatment for Patients With Advanced Colorectal Cancer (APICAL-CRC)
Shanghai Changzheng Hospital
NCT04124601 COMPLETED Neoadjuvant Chemoradiotherapy With Sequential Ipilimumab and Nivolumab in Rectal Cancer
Johannes Laengle, MD, PhD
NCT02792842 COMPLETED Exploratory Study of ART-123 for the Prevention of Cancer Treatment Related Symptoms in Patients With Postoperative Stage II / III Colon Cancer
Asahi Kasei Pharma Corporation
NCT04172597 TERMINATED A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced Malignancies
Spectrum Pharmaceuticals, Inc
NCT03665285 COMPLETED A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors
NextCure, Inc.
NCT03530267 COMPLETED Aflibercept and 5-FU vs. FOLFOX as 1st Line Treatment for Elderly or Frail Elderly Patients With Met. Colorectal Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT03376659 TERMINATED Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma
Georgetown University
NCT03693170 COMPLETED Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer
Pierre Fabre Medicament
NCT05468892 COMPLETED Phase II Randomized Study Evaluating the Efficacy of Panitumumab (VEctibix ) and Trifluridine-Tipiracil (LOnsurf) in Pretreated RAS Wild Type Metastatic Colorectal Cancer Patients: the VELO Trial
University of Campania Luigi Vanvitelli
NCT03422679 TERMINATED Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies
Cellestia Biotech AG
NCT02316340 COMPLETED Vorinostat Plus Hydroxychloroquine Versus Regorafenib in Colorectal Cancer
The University of Texas Health Science Center at San Antonio
NCT03135652 WITHDRAWN Consolidative Radiotherapy for Colorectal Cancer Liver Metastases Receiving Surgery or Radiofrequency Ablation
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT03193814 WITHDRAWN Safety and Efficacy Study of Chemotherapy Plus Apatinib as Second-line Therapy in Metastatic Colorectal Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT04558684 SUSPENDED Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT03439462 COMPLETED Nab-Sirolimus in Combination With FOLFOX & BEV as 1st Line Therapy in Patients With Advanced or Metastatic Colorectal Cancer
Aadi Bioscience, Inc.
NCT05363605 TERMINATED A Study of [225Ac]-FPI-1966 in Participants With Advanced Solid Tumours
Fusion Pharmaceuticals Inc.
NCT02870920 COMPLETED Durvalumab and Tremelimumab and Best Supportive Care vs Best Supportive Care in Patients With Advanced Colorectal Cancer
Canadian Cancer Trials Group
NCT03485027 COMPLETED Rechallenge of Prior Regimen in Third or Later-line Chemotherapy in Metastatic Colorectal Cancer
Fudan University
NCT02363374 COMPLETED Induction Chemotherapy Before or After Preoperative Chemoradiotherapy and Surgery for Locally Advanced Rectal Cancer
Prof. Dr. med. Claus Rödel
NCT04166383 COMPLETED VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC)
National Cancer Institute (NCI)
NCT03555149 TERMINATED A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Colorectal Cancer (Morpheus-CRC)
Hoffmann-La Roche
NCT04854434 TERMINATED A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations
Karyopharm Therapeutics Inc
NCT04751955 WITHDRAWN A Phase lb/ll, Open Label, Single Arm Study With Olinvacimab and Capecitabine in mCRC Patients (OLCAP)
Korean Cancer Study Group
NCT03206073 COMPLETED A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer
National Cancer Institute (NCI)
NCT03854799 COMPLETED Immunotherapy In Locally Advanced Rectal Cancer
Gruppo Oncologico del Nord-Ovest
NCT03592641 TERMINATED Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer
National Cancer Institute (NCI)
NCT03721653 COMPLETED FOLFOXIRI + Bev + Atezo vs FOLFOXIRI + Bev as First-line Treatment of Unresectable Metastatic Colorectal Cancer Patients
Gruppo Oncologico del Nord-Ovest
NCT05092750 WITHDRAWN Magnetic Particle-ICG Lymph Node Mapping in Colorectal Cancer
M.D. Anderson Cancer Center
NCT02535988 WITHDRAWN Abscopal Effect for Metastatic Colorectal Cancer
Zhejiang Provincial People's Hospital
NCT03953235 COMPLETED A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens
Gritstone bio, Inc.
NCT03639714 COMPLETED A Study of a Personalized Neoantigen Cancer Vaccine
Gritstone bio, Inc.
NCT05412706 WITHDRAWN Niraparib Maintenance Treatment in mCRC With a Partial o Complete Response After Oxaliplatin-based Induction Therapy
Ospedale Policlinico San Martino
NCT04312360 COMPLETED Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma (MEFO-trial)
Zealand University Hospital
NCT03156036 COMPLETED Preoperative CRT With Capecitabine ± Temozolomide in Patients With LARC
Asan Medical Center
NCT04166435 COMPLETED TMZ + Olaparib for MGMT Hypermethylated Colorectal Cancer
Yale University
NCT04066894 TERMINATED Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
M.D. Anderson Cancer Center
NCT03602079 COMPLETED Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
Klus Pharma Inc.
NCT03576131 TERMINATED GEN1029 (HexaBody®-DR5/DR5) Safety Trial in Patients With Malignant Solid Tumors
Genmab
NCT02460198 COMPLETED Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unresectable or Metastatic Colorectal Cancer (MK-3475-164/KEYNOTE-164)
Merck Sharp & Dohme LLC
NCT04126733 COMPLETED Study on the Effectiveness and Safety of the Combination of the Two Drugs Regorafenib and Nivolumab in Patients With Colorectal Cancer (Cancer of the Colon or Rectum Classified as Proficient Mismatch Repair and Microsatellite Stable)
Bayer
NCT03735680 COMPLETED A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer
OncoNano Medicine, Inc.
NCT05116891 COMPLETED A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors
Cantargia AB
NCT03428126 COMPLETED Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon Cancer
M.D. Anderson Cancer Center
NCT05025631 COMPLETED A Phase II Study on Dose Optimization of Fruquintinib in Elderly mCRC Patients Refractory to Standard Treatment(DOFEMCRC)
Zhen-Yu Ding
NCT02682485 WITHDRAWN Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
University of Chicago
NCT04696848 TERMINATED The Efficacy and Safety of CKD516 Combined With Durvalumab in Patient Refractory Solid Tumors
Tae Won Kim
NCT05816980 COMPLETED Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients
Aarhus University Hospital
NCT03279289 COMPLETED Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
NCT03801915 COMPLETED Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers
National Cancer Institute (NCI)
NCT03770689 COMPLETED Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer
EMD Serono Research & Development Institute, Inc.
NCT02399813 COMPLETED A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal
Advaxis, Inc.
NCT03299660 COMPLETED Avelumab With Chemoradiation in Locally Advanced Rectal Cancer
Peter MacCallum Cancer Centre, Australia
NCT03435640 TERMINATED REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies
Nektar Therapeutics
NCT04177602 TERMINATED Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial
Universitätsklinikum Hamburg-Eppendorf
NCT05730673 WITHDRAWN Leronlimab in Combination With Regorafenib in Patients With CCR5+, Metastatic Colorectal Cancer
CytoDyn, Inc.
NCT03791398 TERMINATED BrUOG 379 Phase Ib/II Trial ONC201 + Nivolumab in MSS mCRC
Brown University
NCT04790448 COMPLETED Efficacy of VIC Regimen in BRAF Mutant Metastatic Colorectal Cancer
Sun Yat-sen University
NCT03493061 COMPLETED A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM
Sun Yat-sen University
NCT04224415 COMPLETED Re-challenge of Anti-EGFR for Patients With RAS/BRAF Wild-type Metastatic CRC
Yuhong Li
NCT03202758 COMPLETED Evaluation of the Safety and the Tolerability of Durvalumab Plus Tremelimumab Combined With FOLFOX in mCRC
Centre Georges Francois Leclerc
NCT03043729 COMPLETED mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer
AIO-Studien-gGmbH
NCT04021589 COMPLETED Chemotherapy w/wo WeiLeShu in Metastatic Colorectal Cancer
Zhejiang University
NCT03982173 WITHDRAWN Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid Tumors
Gustave Roussy, Cancer Campus, Grand Paris
NCT02713529 COMPLETED Safety and Efficacy Study of AMG 820 and Pembrolizumab Combination in Select Advanced Solid Tumor Cancer
AmMax Bio, Inc.
NCT03251612 COMPLETED Predictive Value of Drug Sensitivity Testing Tumorspheres From Patients With Metastatic Colorectal Cancer
Vejle Hospital
NCT03906565 SUSPENDED Clinical Study of Utidelone Injection in Patients With Advanced or Metastatic Colorectal Cancer
Beijing Biostar Pharmaceuticals Co., Ltd.
NCT03458975 COMPLETED Targeted Delivery of Chemotherapy With Ultrasound and Microbublles
University Hospital, Tours
NCT02963831 COMPLETED A Study to Investigate ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies
Ludwig Institute for Cancer Research
NCT04009876 COMPLETED A Study to Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer
Fundación de investigación HM
NCT04591379 COMPLETED Intratumoral Influenza Vaccine for Early Colorectal Cancer
Zealand University Hospital
NCT05062720 WITHDRAWN Local Consolidative Therapy in Colorectal Cancer
Fox Chase Cancer Center
NCT03007407 COMPLETED Study of Durvalumab and Tremelimumab After Radiation for Microsatellite Stable Metastatic Colorectal Cancer Progressing on Chemotherapy
NSABP Foundation Inc
NCT05622357 COMPLETED Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer
National Cancer Institute, Egypt
NCT04368507 COMPLETED To Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of YYB101 With Irinotecan, Patients Who Are Metastatic or Recurrent Colorectal Cancer Patients
CellabMED
NCT05178576 WITHDRAWN A Single Arm Phase II Study to Evaluate Treatment With Gevokizumab in Patients With Stage II/III Colon Cancer Who Are ctDNA-positive After Curative Surgery and Adjuvant Chemotherapy
NSABP Foundation Inc
NCT05433402 WITHDRAWN Repurposing the Antipsychotic Drug Chlorpromazine as Adjuvant Therapeutic Agent for Resected Stage III Colon Cancer
Sadat City University
NCT03781778 TERMINATED Pilot Trial of Resistant Starch in Stage I-III Colorectal Cancer Survivors
Fred Hutchinson Cancer Center
NCT02713373 COMPLETED Cetuximab and Pembrolizumab in Treating Patients With Colorectal Cancer That is Metastatic or Cannot Be Removed by Surgery
Roswell Park Cancer Institute
NCT03174405 COMPLETED Avelumab and Cetuximab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer - The Phase II AVETUX-CRC Trial.
AIO-Studien-gGmbH
NCT03965845 COMPLETED A Study of Telaglenastat (CB-839) in Combination With Palbociclib in Patients With Solid Tumors
Calithera Biosciences, Inc
NCT03227926 COMPLETED Rechallenge With Panitumumab Driven by RAS Dynamic of Resistance
Fondazione del Piemonte per l'Oncologia
NCT05091528 TERMINATED A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive Cancers
Silverback Therapeutics
NCT02300922 TERMINATED Pretargeted Radioimmunotherapy in Metastatic Colorectal Cancer
Nantes University Hospital
NCT02587247 COMPLETED ImmunoTEP With 68-Ga in Metastatic Colo Rectal Cancer
Nantes University Hospital
NCT02569645 COMPLETED Rosuvastatin in the Treatment of Rectal Cancer
AHS Cancer Control Alberta
NCT03542877 COMPLETED Investigating Cabozantinib in Patients With Refractory Metastatic Colorectal Cancer
Academic Thoracic Oncology Medical Investigators Consortium
NCT04080843 COMPLETED Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients
Zhejiang University
NCT03122509 COMPLETED A Clinical Trial of Durvalumab and Tremelimumab, Administered With Radiation Therapy or Ablation in Patients With Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT03086538 COMPLETED Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy
Samsung Medical Center
NCT05414461 COMPLETED Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer
First Affiliated Hospital of Zhejiang University
NCT03332498 COMPLETED Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers
H. Lee Moffitt Cancer Center and Research Institute
NCT03101475 COMPLETED Synergism of Immunomodulation and Tumor Ablation
European Organisation for Research and Treatment of Cancer - EORTC
NCT03391232 COMPLETED PolyPEPI1018 Vaccine and CDx for the Treatment of Metastatic Colorectal Cancer (OBERTO)
Treos Bio Zrt
NCT02399943 COMPLETED A Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Advanced Colorectal Cancer
University Health Network, Toronto
NCT04561336 COMPLETED Avelumab Plus Cetuximab in Pre-treated RAS Wild Type Metastatic Colorectal Cancer
University of Campania Luigi Vanvitelli
NCT03666442 COMPLETED Early Evaluation of Chemosensitivity for Low/Intermediated-risk Mid-low Stage II/III Rectal Cancer
West China Hospital
NCT03102047 COMPLETED Study of Durvalumab (MEDI4736) After Chemo-Radiation for Microsatellite Stable Stage II-IV Rectal Cancer
NSABP Foundation Inc
NCT03799731 COMPLETED Study for Evaluation of Murlentamab (GM102) Anti-tumoral Activity in Colorectal Cancers
GamaMabs Pharma
NCT05316818 COMPLETED Triplet (FOLFOXIRI) vs. Doublet (FOLFOX or FOLFIRI) Regimen as a 1st Line Treatment in Metastatic Colorectal Carcinoma
Kasr El Aini Hospital
NCT04425239 COMPLETED Intermittent or Continuous Panitumumab Plus FOLFIRI for RAS/B-RAF Wild-type Metastatic Colorectal Cancer
National Cancer Institute, Naples
NCT03832621 COMPLETED NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Microsatellite Stable, MGMT Silenced Metastatic Colorectal Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
NCT02439385 COMPLETED Avastin/FOLFIRI in Combination With Curcumin in Colorectal Cancer Patients With Unresectable Metastasis
Gachon University Gil Medical Center
NCT03000374 COMPLETED Induction Therapy With Panitumumab + mFOLFOX-6 in Rectal Cancer and Quadruple Wild-type Mutation Before Surgery
Grupo Espanol Multidisciplinario del Cancer Digestivo
NCT04247984 COMPLETED A Comparison of mXELIRI Regimen and FOLFIRI Combined Bevacizumab Regimen as First-line Chemotherapy Regimen for Metastatic Colorectal Cancer
Chinese Academy of Medical Sciences
NCT05274945 COMPLETED Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer
Alexandria University
NCT03254394 COMPLETED Lidocaine for Oxaliplatin-induced Neuropathy
Washington University School of Medicine
NCT03454620 COMPLETED A Study to Assess Safety, Efficacy, Immunogenicity, PK of GC1118 With Combination Chemotherapy
Green Cross Corporation
NCT03359681 COMPLETED Metformin Treatment for Colon Cancer
Zealand University Hospital
NCT03403634 COMPLETED Celecoxib, Recombinant Interferon Alfa-2b, and Rintatolimod in Treating Patients With Colorectal Cancer Metastatic to the Liver
Roswell Park Cancer Institute
NCT03875313 TERMINATED Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors
Calithera Biosciences, Inc
NCT02375672 COMPLETED Study of Pembrolizumab in Combination With Chemotherapy for Patients With Advanced Colorectal Cancer
Hoosier Cancer Research Network
NCT03531632 COMPLETED MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer
MacroGenics
NCT04119830 WITHDRAWN Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer
Roswell Park Cancer Institute
NCT03099486 TERMINATED Regorafenib Plus 5-Fluorouracil/Leucovorin Beyond Progression in mCRC
Fox Chase Cancer Center
NCT02465593 TERMINATED A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With Rectal Cancer
PharmaEngine
NCT03271047 COMPLETED Study of Binimetinib + Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Microsatellite-stable (MSS) Metastatic Colorectal Cancer With RAS Mutation
Pfizer
NCT03050814 TERMINATED Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004
National Cancer Institute (NCI)
NCT04001101 WITHDRAWN Anti-PD-1 +/- RT for MSI-H Solid Tumors
University of Colorado, Denver
NCT04165031 TERMINATED A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
Eli Lilly and Company
NCT03661047 WITHDRAWN OMega-3 Fatty Acid for the Immune Modulation of Colorectal Cancer
Massachusetts General Hospital
NCT04430985 WITHDRAWN FOLFOX + Immunotherapy With Intrahepatic Oxaliplatin for Patients With Metastatic Colorectal Cancer
Dorte Nielsen
NCT04620473 WITHDRAWN Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer
Shanghai Minimally Invasive Surgery Center
NCT03803241 COMPLETED Cd133+ Cell Infusion in Patients With Colorectal Liver Metastases.
Hospital San Carlos, Madrid
NCT03261947 COMPLETED A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors
Millennium Pharmaceuticals, Inc.
NCT02851004 TERMINATED Special Combination of BBI608 and Pembrolizumab
Takayuki Yoshino
NCT03647839 COMPLETED Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or STAT3 Inhibition in Order to Synergise With PD1 Inhibition in Microsatellite Stable, Refractory Colorectal Cancer
Australasian Gastro-Intestinal Trials Group
NCT03564912 COMPLETED Prospective Study on the Efficacy and Safety of 2 Week or 3 Week Xelox Regimen for Adjuvant Chemotherapy in CRC
Zhejiang University
NCT02864849 COMPLETED Total Neoadjuvant Induction and Consolidation CapeOX Plus IMRT With Capecitabine for MRI Defined High-risk Rectal Cancer
Peking University Cancer Hospital & Institute
NCT02393755 COMPLETED Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer
Roswell Park Cancer Institute
NCT03142516 COMPLETED FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status
Grupo Espanol Multidisciplinario del Cancer Digestivo
NCT03311750 TERMINATED Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced Colorectal Cancer
Hellenic Cooperative Oncology Group
NCT02448810 TERMINATED Phase 2a Study of BAX69 and 5-FU/Leucovorin or Panitumumab Versus Standard of Care in Subjects With Metastatic Colorectal Cancer
Baxalta now part of Shire
NCT03427268 COMPLETED Clinical Trial of PM60184 in Advanced Colorectal Cancer After Standard Treatment
PharmaMar
NCT04464967 WITHDRAWN Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers
NKGen Biotech, Inc.
NCT02340949 COMPLETED Induction FOLFOX With or Without Aflibercept Followed by Chemoradiation in High Risk Locally Advanced Rectal Cancer
Grupo Espanol Multidisciplinario del Cancer Digestivo
NCT03576963 WITHDRAWN Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer
University of Southern California
NCT02811497 COMPLETED Study of Azacitidine and Durvalumab in Advanced Solid Tumors
University Health Network, Toronto
NCT02953782 COMPLETED Study of Magrolimab (Hu5F9-G4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer
Gilead Sciences
NCT02641691 COMPLETED Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum
Washington University School of Medicine
NCT02981524 COMPLETED Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT03443661 COMPLETED Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer
Aiping Zhou
NCT03149679 TERMINATED The p53 Colorectal Cancer Trial
Haukeland University Hospital
NCT03170115 TERMINATED Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer
Instituto Nacional de Cancer, Brazil
NCT03724253 TERMINATED [68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR)
Advanced Accelerator Applications
NCT03524274 WITHDRAWN Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer
Fuda Cancer Hospital, Guangzhou
NCT02469480 COMPLETED Intravenous Ferric Carboxymaltose vs. Oral Iron Substitution in Patients With Metastatic Colorectal Cancer (CRC) and Iron Deficiency Anemia: a Randomized Multicenter Treatment Optimization Study.
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT03152565 COMPLETED Avelumab Plus Autologous Dendritic Cell Vaccine in Pre-treated Metastatic Colorectal Cancer Patients
Grupo Espanol Multidisciplinario del Cancer Digestivo
NCT03549338 TERMINATED Sym004 Versus Futuximab or Modotuximab in Patients With mCRC
Symphogen A/S
NCT04145193 WITHDRAWN Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC
MedImmune LLC
NCT03652298 TERMINATED Effects of a Neuroscience-based Technique on Cancer Patients Announced of a Palliative Disease Progression and Partners
Centre Oscar Lambret
NCT03168139 COMPLETED Olaptesed (NOX-A12) Alone and in Combination With Pembrolizumab in Colorectal and Pancreatic Cancer
TME Pharma AG
NCT02652702 TERMINATED Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of Colorectal Cancer Patients
Zhejiang University
NCT02497157 COMPLETED Bevacizumab + Triplet Treatment for Untreated With Chemotherapy Metastatic Colorectal Cancer
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
NCT04123925 COMPLETED Preoperative Nivolumab in Patients With Locally Advanced Colon Cancer (T3 or T4): a Window-of-opportunity Study
National Cancer Institute, Naples
NCT03480152 TERMINATED Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer
National Cancer Institute (NCI)
NCT02713984 WITHDRAWN A Clinical Research of CAR T Cells Targeting HER2 Positive Cancer
Zhi Yang
NCT03688230 WITHDRAWN Study of Abituzumab in Combination With Cetuximab and FOLFIRI in Patients With Metastatic Colorectal Cancer.
SFJ Pharmaceuticals X, LTD.
NCT02835924 COMPLETED Study Comparing Different Dose Approaches of Induction Treatment of Regorafenib in MCRC
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
NCT02280694 COMPLETED Low Dose Metronomic Poly-chemotherapy for Metastatic CRC
HaEmek Medical Center, Israel
NCT03323424 WITHDRAWN Phase II Trial Assessing the Efficacy of Immuno-Radiation Abscopal Effect in Patients With Metastatic Cancers
Institut de Cancérologie de la Loire
NCT02723578 COMPLETED Pemetrexed and Erlotinib for Metastatic Colorectal Cancer
Yonsei University
NCT02541370 COMPLETED Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
Chinese PLA General Hospital
NCT02335918 COMPLETED A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
Celldex Therapeutics
NCT03272659 WITHDRAWN The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics
Dr. Te Vuong
NCT02260440 COMPLETED A Phase 2 Study of Pembrolizumab (MK-3475) in Combination With Azacitidine in Subjects With Chemo-refractory Metastatic Colorectal Cancer
Anuradha Krishnamurthy
NCT03008499 COMPLETED High-activity Natural Killer Immunotherapy for Small Metastases of Colorectal Cancer
Fuda Cancer Hospital, Guangzhou
NCT02651415 COMPLETED Phase II Study of Perindopril and Regorafenib in mCRC
British Columbia Cancer Agency
NCT03357276 COMPLETED Mix Vaccine for Metastatic Colorectal Cancer
Fuda Cancer Hospital, Guangzhou
NCT03204201 TERMINATED Validation of ICG to Identify the Urethra During Rectal Surgery
Oxford University Hospitals NHS Trust
NCT03161574 WITHDRAWN FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin (CRM) Positive Rectal Cancer
Guangxi Medical University
NCT02613221 COMPLETED A Phase I/II Study for the Safety and Efficacy of Panitumumab in Combination With TAS-102 for Patients With Colorectal Cancer
Takeda
NCT03470350 WITHDRAWN Galunisertib and Capecitabine in Advanced Resistant TGF-beta Activated Colorectal Cancer
The Netherlands Cancer Institute
NCT02973672 COMPLETED Phase I of SGM-101 in Patients With Cancer of the Colon, Rectum or Pancreas
Surgimab
NCT03258398 COMPLETED A Study to Evaluate eFT508 Alone and in Combination With Avelumab in Subjects With MSS Colorectal Cancer
Effector Therapeutics
NCT03431311 TERMINATED T Cell Receptor Based Therapy of Metastatic Colorectal Cancer
Oslo University Hospital
NCT03645876 TERMINATED SHR-1210 in Combination With BP102 and XELOX in Patient With Metastatic Colorectal Cancer
Jiangsu HengRui Medicine Co., Ltd.
NCT03070574 TERMINATED Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Christoph Gasche
NCT02970916 COMPLETED Phase II Trial to Assess FOLFIRI+Aflibercept Efficacy in Patients With Oxaliplatin-pretreated Metastatic Colorectal Cancer With or Without ACE Polymorphisms
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
NCT03898102 COMPLETED Zinc Supplement in Regorafenib Treated mCRC Patient
Chang Gung Memorial Hospital
NCT02568046 TERMINATED Sym004 in Combination With FOLFIRI in Metastatic Colorectal Cancer Patients
Symphogen A/S
NCT02699073 COMPLETED Evaluation of Treatment Response With CHOI and RECIST Criteria and CT Texture Analysis in Patients With Metastatic Colorectal Cancer Treated With Regorafenib
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT02402036 TERMINATED A Biomarker Study in Patients Getting Regorafenib for Metastatic Colorectal Cancer
Georgetown University
NCT03161041 WITHDRAWN Perioperative Chemotherapy With Bevacizumab for Colorectal Carcinomatosis French Part of the Main Bev-IP Study
Hospices Civils de Lyon
NCT02669914 TERMINATED MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
Washington University School of Medicine
NCT03340558 WITHDRAWN Atezolizumab Monotherapy vs Atezolizumab Plus Cobimetinib in Liver Metastases From Colorectal Cancer
Niharika Mettu
NCT02216149 TERMINATED Effects of S-1 and Capecitabine on Coronary Artery Blood Flow
Heikki Joensuu
NCT03182894 WITHDRAWN Epacadostat in Combination With Pembrolizumab and Azacitidine in Subjects With Metastatic Colorectal Cancer
James J Lee
NCT02508077 TERMINATED FOLFIRI and Panitumumab in Treating Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer
City of Hope Medical Center
NCT02654639 TERMINATED Ph 2 Study of TAS-102 / Bevacizumab Maintenance Therapy Post Induction Chemotherapy in Metastatic Colorectal Cancer
Georgetown University
NCT02423954 TERMINATED Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)
Western Regional Medical Center
NCT03222089 WITHDRAWN Phase II Trial of FOLFOXIGIL Versus FOLFOXIRI as First-line Therapy in Patients With mCRC
Fujian Cancer Hospital
NCT03307603 WITHDRAWN Yttrium-90 Radioembolization + Nivolumab for Liver + Extra-hepatic Metastases From Colorectal Cancer
Case Comprehensive Cancer Center
NCT02437656 COMPLETED Combination of Metformin to Neoadjuvant Radiochemotherapy in the Treatment of Locally Advanced Rectal Cancer (METCAP).
Centre Oscar Lambret
NCT02615574 WITHDRAWN A Study of Type-1 Polarized Dendritic Cell (αDC1) Vaccine in Combination With Tumor-Selective Chemokine Modulation (Interferon-α2b, Rintatolimod, and Celecoxib) in Subjects With Chemo-Refractory Metastatic Colorectal Cancer
Pawel Kalinski
NCT03264274 WITHDRAWN Trial of Aflibercept Monotherapy With DCE-US in Chemorefractory Metastatic Colorectal Cancer
Barts & The London NHS Trust
NCT02316496 TERMINATED Rechallenge of Cetuximab Combined With Irinotecan as Third-line Chemotherapy in Patients With Metastatic Colorectal Cancer - Phase II Study
GERCOR - Multidisciplinary Oncology Cooperative Group
NCT02277093 TERMINATED Pacritinib to Inhibit JAK/STAT Signaling in Refractory Colorectal Cancer
Washington University School of Medicine
NCT02413853 WITHDRAWN Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer
University of Southern California
NCT02965417 WITHDRAWN Sym004 in Metastatic Colorectal Cancer and ECD-EGFR Patients
Symphogen A/S
NCT02586610 WITHDRAWN Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer
Osama Rahma, MD
NCT02785068 WITHDRAWN Evaluation of MM-151 + Nal-IRI + 5-FU + Leucovorin in RAS/RAF Wild-type Metastatic Colorectal Cancer
Merrimack Pharmaceuticals
NCT02287727 WITHDRAWN Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent Treatment
Roswell Park Cancer Institute
NCT02235324 WITHDRAWN Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer
University of Southern California
NCT00609310 SUSPENDED Dietary Bioflavonoid Supplementation for the Prevention of Neoplasia Recurrence
Technische Universität Dresden