Landscape → Hepatology

Cirrhosis

219 clinical trials

83 active

219 total (since 2015)

Phase 1 Active

43 total

Phase 2 Active

95 total

Phase 3 Active

62 total

Phase 4 Active

47 total

Top Sponsors (Industry)

Sorted by active Active Done Failed

Yaqrit Ltd 2 0 0

AstraZeneca 1 3 1

Gilead 1 2 2

Boehringer Ingelheim 1 1 1

Zydus Therapeutics Inc. 1 1 0

Madrigal Pharmaceuticals, Inc. 1 1 0

Noorik Biopharmaceuticals AG 1 0 1

Ipsen 1 0 0

PharmaIN 1 0 0

Vir Biotechnology, Inc. 1 0 0

Can-Fite BioPharma 1 0 0

Pharmicell Co., Ltd. 1 0 0

Asia Cell Therapeutics (Shanghai) Co., Ltd. 1 0 0

Bristol-Myers Squibb 0 3 1

AbbVie 0 3 0

NCT04526665 ACTIVE NOT RECRUITING

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)

Ipsen n=161

NCT06461208 RECRUITING

A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis

King's College London n=300

NCT07395141 NOT YET RECRUITING

Albumin in Acute Variceal Bleeding

King George's Medical University n=60

NCT05056220 RECRUITING

Personalized Long-term Human Albumin Treatment in Patients With Decompensated Cirrhosis and Ascites

Aleksander Krag n=240

NCT07347275 NOT YET RECRUITING

A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.

Yaqrit Ltd n=72

NCT03654053 ACTIVE NOT RECRUITING

Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis

VA Office of Research and Development n=142

NCT03301506 ACTIVE NOT RECRUITING

Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)

Gilead Sciences n=500

NCT06941415 NOT YET RECRUITING

Bumetanide vs. Furosemide in Cirrhosis

Stacy Johnson n=500

NCT06007846 RECRUITING

A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer

Inova Health Care Services n=12

NCT06121479 ENROLLING BY INVITATION

Oral Branched-chain Amino Acid Supplementation for Decompensated Cirrhotic Patients

Mahidol University n=30

NCT06121492 ENROLLING BY INVITATION

Oral Branched-chain Amino Acid Supplementation for Cirrhotic Patients With Sarcopenia

Mahidol University n=86

NCT03633279 ACTIVE NOT RECRUITING

Treatment of Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child C

Dayanand Medical College and Hospital n=96

NCT05500222 ACTIVE NOT RECRUITING

A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)

Madrigal Pharmaceuticals, Inc. n=700

NCT06263816 NOT YET RECRUITING

Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial

University Hospital, Tours n=290

NCT05201404 RECRUITING

Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis

Can-Fite BioPharma n=471

NCT02984124 ACTIVE NOT RECRUITING

Communication During Hospitalization About Resuscitation Trial

University of Vermont n=182

NCT06814626 RECRUITING

Role of Nutritional Intervention for the Treatment of Sarcopenia in Cirrhotic Patients with Refractory Ascites Candidate to Transjugular Intrahepatic Portosystemic Shunt Placement and Identification of Prognostic Factors Related to Clinical Outcome

The Mediterranean Institute for Transplantation and Advanced Specialized Therapies n=72

NCT06818279 NOT YET RECRUITING

Compare the Efficacy and Safety of Dabigatran and Enoxaparin in Patients With Portal Vein Thrombosis With Cirrhosis

Institute of Liver and Biliary Sciences, India n=120

NCT04932577 RECRUITING

Faecal Microbiota Transplantation for Liver Cirrhosis

University of Aarhus n=220

NCT05769868 RECRUITING

Efficacy of Esmolol in the Identification of Cardiovascular Disorders by Cirrhosis, Diabetes Mellitus and Cardiotoxic Treatments

Consorcio Centro de Investigación Biomédica en Red (CIBER) n=1,000

NCT06533852 NOT YET RECRUITING

Fecal Microbiome Transplantation in Cirrhosis: Trial in Patients With Decompensated Cirrhosis

Consorcio Centro de Investigación Biomédica en Red (CIBER) n=190

NCT06478602 RECRUITING

Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis

Cristian Ichim n=30

NCT04689152 RECRUITING

Clinical Trial to Evaluate the Efficacy and Safety of Cellgram-LC Administration in Patients With Alcoholic Cirrhosis

Pharmicell Co., Ltd. n=200

NCT02423395 RECRUITING

Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis

Sherief Abd-Elsalam n=100

NCT04365868 TERMINATED

Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis

Galectin Therapeutics Inc. n=357

NCT04244877 WITHDRAWN

Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility

MetroHealth Medical Center

NCT05080465 COMPLETED

Long Term Follow up Mesenchymal Stem Cell Therapy for Patients Virus-related Liver Cirrhosis

Ukraine Association of Biobank n=700

NCT05253287 COMPLETED

Growth Hormone in Decompensated Liver Cirrhosis

Post Graduate Institute of Medical Education and Research, Chandigarh n=96

NCT05794555 COMPLETED

LiveSMART Trial to Prevent Falls in Patients With Cirrhosis

University of Michigan n=230

NCT07072572 COMPLETED

Lung Point of Care Ultrasound to Guide Albumin Administration in Cirrhosis

Centro Medico Issemym n=72

NCT03451292 COMPLETED

Effects of Long-Term Administration of Human Albumin in Participants With Decompensated Cirrhosis and Ascites

Grifols Therapeutics LLC n=410

NCT06000748 TERMINATED

NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients

University of California, San Francisco n=6

NCT03069131 COMPLETED

Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites

Centre Hospitalier Universitaire de Besancon n=160

NCT06355479 COMPLETED

A Study to Evaluate the Efficacy and Safety of OsrHSA in Patients of Hepatic Cirrhosis With Hypoalbuminemia

Healthgen Biotechnology Corp. n=328

NCT02862249 COMPLETED

Trial of Faecal Microbiota Transplantation in Cirrhosis

King's College London n=32

NCT05061992 COMPLETED

A Trial to Improve Quality of Life in People With Cirrhosis

University of Michigan n=56

NCT02837939 WITHDRAWN

Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction

Martin Janičko

NCT05828836 COMPLETED

Allopurinol and Quality of Life in Liver Cirrhosis

Tanta University n=100

NCT03439254 COMPLETED

Study Evaluating the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis

Intercept Pharmaceuticals n=919

NCT05674877 COMPLETED

Opioid Sparing Anesthesia in Patients With Liver Cirrhosis Undergoing Liver Resection

Cairo University n=100

NCT02824354 WITHDRAWN

Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence.

Centre Hospitalier Universitaire, Amiens

NCT05545670 COMPLETED

Allopurinol to Prevent Cirrhosis Related Morbidities

Tanta University n=100

NCT03420144 COMPLETED

Growth Hormone Therapy in Liver Cirrhosis

Post Graduate Institute of Medical Education and Research, Chandigarh n=76

NCT02596880 COMPLETED

Sofosbuvir, Daclatasvir, Ribavirin for Hepatitis C Virus (HCV) Cirrhotics

Tehran University of Medical Sciences n=100

NCT02823353 COMPLETED

Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis

Xijing Hospital of Digestive Diseases n=117

NCT04775329 TERMINATED

Primary Prophylaxis for Spontaneous Bacterial Peritonitis

Changi General Hospital n=2

NCT04113317 COMPLETED

Granulocyte-Colony Stimulating Factor (G-CSF) as Optimizing Therapy for Pediatric Liver Transplantation

Fakultas Kedokteran Universitas Indonesia n=52

NCT03368066 COMPLETED

Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?

University of Virginia n=100

NCT03154476 COMPLETED

Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study

Mayo Clinic n=20

NCT02642432 COMPLETED

A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1, 2, 4, 5 or 6 Infection and Compensated Cirrhosis

AbbVie n=146

NCT02738138 COMPLETED

A Study to Evaluate the Efficacy and Safety of Experimental Drugs ABT- 493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1-6 Infection and Human Immunodeficiency Virus -1 Coinfection (EXPEDITION-2)

AbbVie n=153

NCT04155515 COMPLETED

A Phase III Study to Evaluate Efficacy and Safety of TG-2349 in Combination With DAG181 and RBV for HCV Type I Patients

Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd. n=370

NCT02602210 TERMINATED

Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis

Universitaire Ziekenhuizen KU Leuven n=100

NCT04140591 TERMINATED

Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis

Taipei Veterans General Hospital, Taiwan n=10

NCT02597166 COMPLETED

Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infection

University Health Network, Toronto n=14

NCT03695705 COMPLETED

Rifaximin and Norfloxacin for Prevention of SBP in Adults With Decompensated Cirrhosis

Post Graduate Institute of Medical Education and Research, Chandigarh n=142

NCT02705534 COMPLETED

Sofosbuvir, Ledipasvir, Ribavirin for Hepatitis C Cirrhotics, Genotype 1

Tehran University of Medical Sciences n=50

NCT02271295 SUSPENDED

Impact on Morbidity and Mortality of Prophylactic Dosing of Low Molecular Heparin in Child-Pugh B Cirrhotic Patients

Assistance Publique - Hôpitaux de Paris n=16

NCT02442284 COMPLETED

A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With or Without Ribavirin in US Veterans With Genotype 1 Chronic Hepatitis C Virus Infection

AbbVie n=99

NCT02451033 COMPLETED

Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study

Post Graduate Institute of Medical Education and Research, Chandigarh n=65

NCT03070353 COMPLETED

Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury

Ramathibodi Hospital n=10

NCT02319200 TERMINATED

Primary Prevention Hepatocellular Carcinoma by Metformin

Assistance Publique - Hôpitaux de Paris n=11

NCT02968810 ACTIVE NOT RECRUITING

Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis

National Cancer Institute (NCI)

NCT06764966 RECRUITING

Statin and Beta Blocker Use in Patients With Decompensated Cirrhosis

CAMC Health System

NCT07325526 NOT YET RECRUITING

A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

Boehringer Ingelheim

NCT05726032 RECRUITING

Empagliflozin in Patients With Cirrhosis and Ascites

Yale University

NCT06823713 RECRUITING

RTX001 Autologous Engineered Macrophages for Liver Cirrhosis

Resolution Therapeutics Limited

NCT07350070 NOT YET RECRUITING

TACE Combined With Tislelizumab, Lenvatinib, and Carvedilol for Unresectable HCC With Cirrhotic Portal Hypertension

Tongji Hospital

NCT05832229 RECRUITING

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT06526104 RECRUITING

Study of Tremelimumab and Durvalumab (MEDI4736) (T300+D) in Advanced Hepatocellular Carcinomas With Child-Pugh-B Cirrhosis

The University of Texas Health Science Center at San Antonio

NCT04172779 NOT YET RECRUITING

Erlotinib for Hepatocellular Carcinoma Chemoprevention

University of Texas Southwestern Medical Center

NCT04250259 RECRUITING

SAMe Trial for Patients With Alcoholic Cirrhosis

Indiana University

NCT05028829 RECRUITING

Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk

Raymond Chung

NCT06015022 RECRUITING

EGCG for Hepatocellular Carcinoma Chemoprevention

University of Texas Southwestern Medical Center

NCT06890039 NOT YET RECRUITING

A-TANGO Phase 2 Study

Yaqrit Ltd

NCT04873102 RECRUITING

Danazol for Treatment of Cytopenias in Patients With Cirrhosis

University of Southern California

NCT07053488 RECRUITING

CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection

AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC

NCT07042919 NOT YET RECRUITING

Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

Northwestern University

NCT06937307 RECRUITING

Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

Giuseppe Cullaro, MD

NCT05548452 RECRUITING

Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease

Virginia Commonwealth University

NCT06687265 RECRUITING

Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal Hypertension

Assistance Publique - Hôpitaux de Paris

NCT05895136 RECRUITING

A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).

European Foundation for Study of Chronic Liver Failure

NCT06144086 ACTIVE NOT RECRUITING

A Phase 2 Trial of Foscenvivint in Liver Cirrhosis Patients Caused by HIV/HCV Co-infection with Hemophilia (OP-724-H201)

Kiminori Kimura, MD

NCT06812390 RECRUITING

Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites

Anahita Rabiee MD MHS

NCT05869591 RECRUITING

DOAC in Patients with Child a or B Liver Cirrhosis

Centre Hospitalier Universitaire Vaudois

NCT06052176 RECRUITING

Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT06256432 RECRUITING

Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome

Noorik Biopharmaceuticals AG

NCT05027425 ACTIVE NOT RECRUITING

Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant

Davendra Sohal

NCT05224960 RECRUITING

Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-2)

Beijing 302 Hospital

NCT05304234 RECRUITING

Liver Cancer Disparities in American Indian and Alaska Native Persons

University of Washington

NCT05948982 NOT YET RECRUITING

Safety of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in Patients With Decompensated Hepatitis B Cirrhosis

Asia Cell Therapeutics (Shanghai) Co., Ltd.

NCT06675929 COMPLETED

A Study to Test How Well BI 770371 is Tolerated by People With Cirrhosis Caused by a Liver Disease Called MASH

Boehringer Ingelheim

NCT06269484 COMPLETED

A Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Participants With Cirrhosis-ZEAL-UNLOCK

AstraZeneca

NCT06987968 TERMINATED

A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy

Genfit

NCT05904470 COMPLETED

A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV

Atea Pharmaceuticals, Inc.

NCT05516498 TERMINATED

Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study)

AstraZeneca

NCT06750276 COMPLETED

A Study to Evaluate the Safety, Tolerability, PK, and PD Effects of AZD2389 in Participants With Liver Fibrosis and Compensated Cirrhosis.

AstraZeneca

NCT06082843 TERMINATED

A Study to Test Whether Avenciguat Helps People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver) Who Had Bleeding in the Esophagus or Fluid Accumulation in the Belly

Boehringer Ingelheim

NCT03796598 COMPLETED

FMT in Cirrhosis and Hepatic Encephalopathy

VA Office of Research and Development

NCT04210245 COMPLETED

Study of Aldafermin (NGM282) in Subjects With Compensated Cirrhosis (ALPINE 4)

NGM Biopharmaceuticals, Inc

NCT03941405 COMPLETED

Albumin for Management of Hypervolemic Hyponatremia (AlbuCAT)

Fundacion Clinic per a la Recerca Biomédica

NCT02609048 TERMINATED

Study to Evaluate the Effects of Two Doses of Seladelpar (MBX-8025) in Subjects With Primary Biliary Cirrhosis (PBC)

Gilead Sciences

NCT04899115 COMPLETED

VE303 for Treatment of Hepatic Encephalopathy (HE)

Patricia Bloom

NCT03112681 COMPLETED

Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Mg in Patients With Primary Biliary Cholangitis

Zydus Therapeutics Inc.

NCT04522869 COMPLETED

Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation for Children Suffering From Biliary Atresia

Vinmec Research Institute of Stem Cell and Gene Technology

NCT03468699 COMPLETED

Autologous Bone Marrow Mononuclear Stem Cell for Children Suffering From Liver Cirrhosis Due to Biliary Atresia

Vinmec Research Institute of Stem Cell and Gene Technology

NCT04112199 TERMINATED

A Study for Evaluation of BIV201 to Reduce Ascites and Complications in Patients With Cirrhosis and Refractory Ascites

BioVie Inc.

NCT04604652 COMPLETED

Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis

HighTide Biopharma Pty Ltd

NCT04874350 COMPLETED

A Study to Assess the Efficacy, Safety, and Tolerability of Oral LPCN 1148 in Male Subjects With Cirrhosis of the Liver and Sarcopenia

Lipocine Inc.

NCT04048707 WITHDRAWN

Angiotensin 2 for Hepatorenal Syndrome

University of California, Los Angeles

NCT06267794 COMPLETED

Prolonged Release Pirfenidone Versus Placebo in Compensated Cirrhosis.

Jorge L Poo

NCT02695628 COMPLETED

[18F]FMISO PET/CT After Transcatheter Arterial Embolization in Imaging Tumors in Patients With Liver Cancer

Stanford University

NCT05309200 COMPLETED

A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury

Ocelot Bio, Inc

NCT04155099 TERMINATED

Investigational Microbiota Restoration Therapeutic for Hepatic Encephalopathy

Ochsner Health System

NCT04082780 COMPLETED

Rifamycin in Minimal Hepatic Encephalopathy

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT03254758 COMPLETED

A Study of ADR-001 in Patients With Liver Cirrhosis

Rohto Pharmaceutical Co., Ltd.

NCT04048876 TERMINATED

Study to Evaluate the Efficacy and Safety of CC-90001 in Participants With Non-alcoholic Steatohepatitis (NASH) and Liver Fibrosis

Celgene

NCT04311489 TERMINATED

Refractory Ascites in Patients With Liver Cirrhosis, and the Potential Treatment With 48 Hours Infusion of Ularitide.

University of Aarhus

NCT03486912 COMPLETED

A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis

Bristol-Myers Squibb

NCT04175392 TERMINATED

Effect of Probiotics in Non-alcoholic Fatty Liver Disease and Steatohepatitis

Corewell Health East

NCT04109144 WITHDRAWN

Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Montefiore Medical Center

NCT02955602 COMPLETED

Seladelpar (MBX-8025) in Subjects With Primary Biliary Cholangitis (PBC)

Gilead Sciences

NCT03656068 COMPLETED

An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosis

Pinnacle Clinical Research, PLLC

NCT03226067 COMPLETED

Study to Assess Safety & Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodiol.

Calliditas Therapeutics AB

NCT03585257 COMPLETED

HEAL STUDY (Hepatic Encephalopathy and Albumin Study)

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT02960204 COMPLETED

Emricasan, an Oral Caspase Inhibitor, in Subjects With NASH Cirrhosis and Severe Portal Hypertension

Histogen

NCT03420768 COMPLETED

A Study of Experimental Medication BMS-986263 in Adults With Advanced Hepatic Fibrosis After Cure of Hepatitis C

Bristol-Myers Squibb

NCT03059446 TERMINATED

Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis

Tobira Therapeutics, Inc.

NCT03908255 WITHDRAWN

Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma

Louisiana State University Health Sciences Center in New Orleans

NCT02802228 COMPLETED

Study to Assess Safety and Efficacy of Ifetroban for Treatment of Portal Hypertension in Cirrhotic Patients

Cumberland Pharmaceuticals

NCT02965911 WITHDRAWN

Efficacy and Safety of Fenofibrate Combined With UDCA in PBC Patients With an Incomplete Biochemical Response to UDCA

Beijing 302 Hospital

NCT04397289 COMPLETED

Anticoagulation Therapy After Splenectomy in Cirrhosis Patient

First Affiliated Hospital Xi'an Jiaotong University

NCT03712280 COMPLETED

MNK6106 for Liver Disease (Hepatic Cirrhosis) That in the Past Has Affected the Brain (Hepatic Encephalopathy)

Mallinckrodt

NCT03107091 COMPLETED

Continuous Infusion Terlipressin for Patients With Cirrhosis and Refractory Ascites

BioVie Inc.

NCT03447730 TERMINATED

Safety, Tolerability and Pharmacodynamics of SYNB1020

Synlogic

NCT03827200 TERMINATED

A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis

Noorik Biopharmaceuticals AG

NCT03593447 COMPLETED

To Evaluate Efficacy and Safety in TG-2349 Combination With DAG181 (± Ribavirin) in HCV Genotype I Infected Patients

Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.

NCT03476993 TERMINATED

Non-comparative Study of BCD-085 in Combination With UDCA in Patients With Primary Biliary Cholangitis

Biocad

NCT02321306 WITHDRAWN

An Open-label Study to Evaluate the Long-term Safety and Tolerability of LUM001 in Patients With Primary Biliary Cirrhosis

Mirum Pharmaceuticals, Inc.

NCT02669875 COMPLETED

Serelaxin To Lower Portal Pressure

University of Edinburgh

NCT02360852 TERMINATED

IBAT Inhibitor A4250 for Cholestatic Pruritus

Sahlgrenska University Hospital

NCT04874428 RECRUITING

Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver Cirrhosis

Insel Gruppe AG, University Hospital Bern

NCT07069725 RECRUITING

The Phase 1, Open-label, PET Trial Designed to Investigate the Effect of AZD2389 on FAP Occupancy in the Liver in Participants With Advanced Liver Fibrosis.

AstraZeneca

NCT05045482 RECRUITING

Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease

Zydus Therapeutics Inc.

NCT06455280 RECRUITING

A Study of SIPLIZUMAB in AILD and LT Patients

Elizabeth C. Verna

NCT06871111 RECRUITING

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

University of Chicago

NCT02626312 ACTIVE NOT RECRUITING

Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function

M.D. Anderson Cancer Center

NCT05490888 RECRUITING

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

PharmaIN

NCT05484206 RECRUITING

Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434

Vir Biotechnology, Inc.

NCT06671275 ENROLLING BY INVITATION

A Clinical Study to Evaluate CUD005 Injection in Patients with Liver Cirrhosis

Anhui Provincial Hospital

NCT06629909 NOT YET RECRUITING

Safety and Feasibility of Human Umbilical Cord Mesenchymal Stem Cell-Derived Secretome in the Treatment of Liver Cirrhosis: a Comprehensive Evaluation of Fibrosis Reduction, Immunomodulation, and Hepatic Regeneration: a Single Center, Randomized, Phase I Clinical Trial

Baermed

NCT03278925 ACTIVE NOT RECRUITING

Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis

National Cancer Institute (NCI)

NCT05331872 COMPLETED

Umbilical Cord-derived Mesenchymal Stem Cell Infusion in the Management of Adult Liver Cirrhosis

Vinmec Research Institute of Stem Cell and Gene Technology

NCT06715670 COMPLETED

A Study to Investigate the Blood Concentrations of 4 Different Oral Doses of Zibotentan in Healthy Non-Asian and Japanese Participants

AstraZeneca

NCT06525311 COMPLETED

A Study to Evaluate the Pharmacokinetics and Safety of K-808 (Pemafibrate) in Subjects With Primary Biliary Cholangitis With Compensated Cirrhosis and Without Cirrhosis.

Kowa Research Institute, Inc.

NCT04950764 COMPLETED

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Gilead Sciences

NCT05939947 COMPLETED

A Clinical Trial of ALE.F02 in Patients With Advanced Liver Fibrosis and/or With Mild Cirrhosis

Alentis Therapeutics AG

NCT02143401 COMPLETED

Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors

National Cancer Institute (NCI)

NCT04688034 COMPLETED

Safety and Tolerability Study of OP-724 in Liver Cirrhosis Patients by HIV/HCV with Hemophilia.

Kiminori Kimura, MD

NCT03082937 COMPLETED

An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects

Albireo

NCT05835180 COMPLETED

A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Sagimet Biosciences Inc.

NCT04643795 COMPLETED

Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects

Madrigal Pharmaceuticals, Inc.

NCT05013502 COMPLETED

Empagliflozin in Diuretic Refractory Ascites

Stanford University

NCT04060147 TERMINATED

Safety and Tolerability of Cilofexor in Participants With Primary Sclerosing Cholangitis (PSC) and Compensated Cirrhosis

Gilead Sciences

NCT04047160 COMPLETED

Safety, Tolerability of OP-724 in Patients With Primary Biliary Cholangitis (Phase I)

Kiminori Kimura, MD

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Fecal Transplant in Recurrent Hepatic Encephalopathy

Jasmohan Bajaj

NCT04055389 WITHDRAWN

Preventing de Novo Portal Vein Thrombosis With Antithrombin-III in Patients With Cirrhosis

Jonathan Stine

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OCR002-SP103 - Oral Immediate Release Study

Ocera Therapeutics, Inc.

NCT03152188 COMPLETED

Oral Fecal Transplant in Cirrhosis

Virginia Commonwealth University

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Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT03445208 COMPLETED

A Study of Experimental Medication BMS-986036 Given to Healthy Participants

Bristol-Myers Squibb

NCT02297867 COMPLETED

Clinical Trial Study About Human Adipose-Derived Stem Cells in the Liver Cirrhosis

Gwo Xi Stem Cell Applied Technology Co., Ltd.

NCT05147090 ACTIVE NOT RECRUITING

Effects of Empagliflozin on Fibrosis and Cirrhosis in Chronic Hepatitis B Patients

The University of Hong Kong

NCT07352228 ENROLLING BY INVITATION

Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices

Xijing Hospital

NCT07322237 RECRUITING

DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis

Post Graduate Institute of Medical Education and Research, Chandigarh

NCT07270874 NOT YET RECRUITING

Study to Evaluate the Efficacy of Intravenous Administration of Human Albumin Versus Saline Solution in Patients With descompénsate Cirrhosis Grade 1B or Higher Renal Failure

Fundacion Clinic per a la Recerca Biomédica

NCT06084234 RECRUITING

National Liver Cancer Screening Trial

University of Texas Southwestern Medical Center

NCT04592744 ENROLLING BY INVITATION

Angiotensin 2 for AKI After OLT

University of California, Los Angeles

NCT07132515 RECRUITING

Efficacy & Safety of Anticoagulants in Cirrhosis ± HCC

Mansoura University

NCT06538077 RECRUITING

BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE

Post Graduate Institute of Medical Education and Research, Chandigarh

NCT04448028 RECRUITING

Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial

Universitätsklinikum Hamburg-Eppendorf

NCT06808074 RECRUITING

A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis

Asian Institute of Gastroenterology, India

NCT06881628 RECRUITING

Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients

Tanta University

NCT06594783 RECRUITING

Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders

Taipei Veterans General Hospital, Taiwan

NCT05737030 ACTIVE NOT RECRUITING

Effect of L-ornithine-L-aspertate (LOLA) on the Gut Microbiome

Medical University of Graz

NCT04073290 RECRUITING

Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT05667805 RECRUITING

Coagulation in Cirrhosis

Medical University of Vienna

NCT04588077 RECRUITING

Comparison Between 2-dose Versus 3-dose Regimens of Heplisav B in Cirrhosis

Mercy Medical Center

NCT05783661 RECRUITING

Trial Comparing Conventional Antibiotic Strategies Versus Regimens Guided by Epidemiological Surveillance in Infected Patients With Cirrhosis (SURVIC_STUDY)

Eva Bonfill

NCT06277882 RECRUITING

Efficacy and Durability of Hepatitis A Vaccination in Patients With Advanced Fibrosis and Cirrhosis

Mahidol University

NCT05872698 RECRUITING

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.

King's College Hospital NHS Trust

NCT07439536 COMPLETED

Dose Optimization of Sitagliptin and Duloxetine in Diabetic Cirrhosis

Kafrelsheikh University

NCT07397481 COMPLETED

Clinical Application of Simcyp-Guided Doses of Antihypertensive Drugs in Cirrhotic Patients

Kafrelsheikh University

NCT04216784 TERMINATED

Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients

Rush University Medical Center

NCT05178303 COMPLETED

Composition for Treating Cirrhosis and Liver Cancer (SB-1121)

Nguyen Thi Trieu, MD

NCT04645550 COMPLETED

Apixaban, Warfarin and Aspirin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy（ESAWAAPT）

Northern Jiangsu People's Hospital

NCT06630572 TERMINATED

Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes

University of Roma La Sapienza

NCT05724485 COMPLETED

Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis

Mahidol University

NCT04218695 COMPLETED

Prophylactic Antibiotics in Admitted Cirrhotics

Beth Israel Deaconess Medical Center

NCT05687409 COMPLETED

Synbiotics Interventions for Managing Cirrhosis and Its Complications

First Affiliated Hospital of Zhejiang University

NCT03176966 COMPLETED

Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis

Vanderbilt University Medical Center

NCT04976543 COMPLETED

Safety of Anticoagulant Therapy After Endoscopic Treatment

Qilu Hospital of Shandong University

NCT03633227 TERMINATED

Study of Obeticholic Acid (OCA) Evaluating Pharmacokinetics and Safety in Participants With Primary Biliary Cholangitis (PBC) and Hepatic Impairment

Intercept Pharmaceuticals

NCT03175731 COMPLETED

PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)

Yanjing Gao

NCT03091738 COMPLETED

Ramelteon for Treatment of Insomnia in Cirrhosis

Virginia Commonwealth University

NCT04173429 COMPLETED

Efficacy and Safety of Anticoagulant Therapy in Portal Vein Thrombosis

Qilu Hospital of Shandong University

NCT02533934 COMPLETED

Sofosbuvir Based DAA Therapy in HIV/HCV Coinfected Pre or Post Liver Transplant

University of California, San Francisco

NCT04243681 COMPLETED

Combination of Autologous MSC and HSC Infusion in Patients With Decompensated Cirrhosis

Asian Institute of Gastroenterology, India

NCT02907749 COMPLETED

Spironolactone on Fibrosis Progrssion-Portal Hypertension(FP-PH)in Cirrhosis

Changqing Yang

NCT04358016 COMPLETED

Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding

Changhai Hospital

NCT03769597 COMPLETED

Description of the Evolution of Plasma and Urinary Concentrations of Iohexol in a Cirrhotic Patient Population

University Hospital, Limoges

NCT03202524 WITHDRAWN

Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Montefiore Medical Center

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Study to Evaluate the Safety and Efficacy of Daclatasvir/Sofosbuvir/Ribavirin for 16 Versus 24 Weeks for HCV Genotype 3 Cirrhotics

Tarek I. Hassanein, M.D., FACP, FAG, AGAF

NCT03309592 WITHDRAWN

Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary Hypertension

Ochsner Health System

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Evaluation of Hepatic Function Using Gadoxetic Acid Enhanced MRI

Seoul National University Hospital

NCT03120637 COMPLETED

Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue

Institute of Liver and Biliary Sciences, India

NCT02557360 COMPLETED

Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis

Pomeranian Medical University Szczecin

NCT02019784 COMPLETED

Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy

King's College Hospital NHS Trust

NCT02702739 COMPLETED

Sofosbuvir/Simeprevir Plus a Flat Dose of Ribavirin in Genotype 1 Elderly HCV Cirrhotic Patients

Azienda Ospedaliera San Camillo Forlanini

Data: ClinicalTrials.gov